DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twin and pde-12

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_499388.1	Gene:	pde-12 / 176514	WormBaseID:	WBGene00011268	Length:	628	Species:	Caenorhabditis elegans

Alignment Length:	371	Identity:	90/371 - (24%)
Similarity:	143/371 - (38%)	Gaps:	80/371 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 VMCYNVLCDKYAT------RQMYGYCPSWALCWEYRK----KSIIDEIRHYAADIISLQEIETEQ 263
            :|.||:|.|.|..      :..:.||...:....||.    |.:.|.|......:|.|||::..:
Worm   309 IMSYNILADLYLNLTLPQEQLFFNYCQKSSQRIIYRTPIFLKQLHDFIHSARCSLIFLQEVDLSR 373

  Fly   264 FYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANA 328
            ..:|.:|.|....|....:.|  ..|:||       |.||.|.:.:|.:|........:||..:.
Worm   374 HENFIVPFLNTISYSSEIAKK--VGTVSE-------GVAIIFDSQRFQVISSKCYGVAELASGDI 429

  Fly   329 EGSDNMLNRVMPKDNIGLAALLKVKENAWEPMS---EVTQI-------SQPLLVC-TAHIHWDPE 382
            .|                  :|:..|.:.|..|   .|.||       :..|||| ..|:|.:|.
Worm   430 LG------------------ILETSEESKERFSTRPTVLQIVVLKDSRTGKLLVCGNTHLHHNPI 476

  Fly   383 FCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSM 447
            ...||::|.:..:.:|..|.:|..      ..|....|.:|..|||||.|:..|...:..|.:.
Worm   477 DEHVKVLQALTCTRKLLEIYEETR------ELNKGIEVLVLFGGDFNSTPNGAVFNLMSMGNLP- 534

  Fly   448 DHLDFKDMGYKSCLQRLLSNDTNEFTHSFKLASAYNEDIMPHTNYTFD-----FKGIIDYIF--- 504
                 |:....:|..::...|. :........:...|    :||||..     |.|.:|||:
Worm   535 -----KEDAVWNCDSKITPQDI-KIDKKMDCLTGTPE----YTNYTASSQKDGFVGCLDYIWGVG 589

  Fly   505 YTKTGMVPLGLLGPVSNDWLRENKVVGCPHPHIPSDHFPLLVELEL 550
            .|.....||     .|::  :..|....|.|..||||.|::.::::
Worm   590 ATSIRHCPL-----PSHE--KVIKYTALPSPISPSDHLPIICDIKI 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	90/369 (24%)
pde-12	NP_499388.1	EEP	309..628	CDD:382041	90/369 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820