DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twin and Noct

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_033964.1	Gene:	Noct / 12457	MGIID:	109382	Length:	429	Species:	Mus musculus

Alignment Length:	377	Identity:	89/377 - (23%)
Similarity:	149/377 - (39%)	Gaps:	94/377 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 PP--QRPWLPLAKPNKTRPACI-----FTVMCYNVLCDKYAT-RQMYGYCPSWALCWEYRKKSII 243
            ||  ||.::.|      |..|.     ..||.:|:|...... :..:..||..||.||.||..|:
Mouse   120 PPRYQRDFVDL------RTDCSSSHSPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLIL 178

  Fly   244 DEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRAS 308
            :||..|..||:.|||:  :.::..|.|.|...||:|.|.||..:..:........||||:||..:
Mouse   179 EEILAYQPDILCLQEV--DHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQN 241

  Fly   309 KFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQISQPLLVC 373
            :|.||..:.|....:.:..              :.:.:|..|:.||:..:....||.:.
Mouse   242 RFKLISSTNIRLTAMTLKT--------------NQVAIAQTLECKESGRQFCIAVTHLK------ 286

  Fly   374 TAHIHWD----PEFCDVKLIQTMMLSNELKTIIDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDS 434
             |...|:    .:.||       :|.| |:.|...|.             :.|::|||||:.|..
Mouse   287 -ARTGWERFRSAQGCD-------LLQN-LQNITQGAK-------------IPLIVCGDFNAEPTE 329

  Fly   435 GVVEFLGKGRVSMDHLDFKDMGYKSCLQRLLSNDTNEFTHSFKLASAYNEDIMPHTNYTFDFKG- 498
            .|.:......::::                         .::||.|...:...|:|.:.....|
Mouse   330 EVYKHFASSSLNLN-------------------------SAYKLLSPDGQSEPPYTTWKIRTSGE 369

  Fly   499 ---IIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCPHPHIPSDHFPLLVE 547
               .:|||:|::..:.....|..::.:.:..|::   |..|.||||..|:.:
Mouse   370 CRHTLDYIWYSRHALSVTSALDLLTEEQIGPNRL---PSFHYPSDHLSLVCD 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563
		LRR_8	75..130	CDD:290566
		leucine-rich repeat	76..98	CDD:275378
		LRR_4	97..136	CDD:289563
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	82/348 (24%)
Noct	NP_033964.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..68
		Deadenylase_nocturnin	142..421	CDD:197330	82/349 (23%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	217..219		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	284..287		0/9 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	322..324		1/1 (100%)
		Interaction with PPARG. /evidence=ECO:0000269\|PubMed:20498072	341..351		2/34 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810