DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment twin and cnot6l

DIOPT Version :9

Sequence 1:	NP_732964.1	Gene:	twin / 42880	FlyBaseID:	FBgn0011725	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001120421.1	Gene:	cnot6l / 100145505	XenbaseID:	XB-GENE-977551	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	301/525 - (57%)
Similarity:	385/525 - (73%)	Gaps:	19/525 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KDKYDSAN-RRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALYLNDNQLLRLP 90
            |:|||..: ||....:|.|::|.|||::|..|||:|.||::|.|||...|||.|:|:||.|.|:|
Frog     3 KEKYDPPDPRRIYTIMSAEEVANGKKSHWDELEISGRVRSLSTSLWTLTHLTVLHLSDNNLSRIP 67

  Fly    91 ADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELLLNNNFLRVLPYEIGKLFHLVILGLMGNPL 155
            .|:..|.:|..||||||||||||||||.::.|||||||||.|||||:|:|:||.|..|||.||||
Frog    68 PDIAKLHNLVYLDLSSNKLRSLPAELGNVVTLRELLLNNNLLRVLPFELGRLFRLQTLGLKGNPL 132

  Fly   156 QKEFMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQRPWLPLAKPNKTRPACIFTVMCYNVLCDKYA 220
            .::.:::|.||:|.:|||.|||||||......|||||:.|.:.::..|:..|||||:||||||||
Frog   133 SQDILSLYQEPDGMRKLLNYMLDNLSVHPEQLPQRPWITLKERDQILPSVSFTVMCFNVLCDKYA 197

  Fly   221 TRQMYGYCPSWALCWEYRKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKS 285
            |||:|||||||||.||||||.|::||....||||||||:||||:|..|:|.||..||:|.|||||
Frog   198 TRQLYGYCPSWALNWEYRKKGIMEEIVSCDADIISLQEVETEQYYTLFMPALKERGYDGFFSPKS 262

  Fly   286 RAKTMSELERKYVDGCAIFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALL 350
            |||.||:.|:|:|||||||||..||:|:::..:||||:||||:|||:.||||||.|||||:..||
Frog   263 RAKIMSDQEKKHVDGCAIFFRTEKFSLVQKHTVEFNQIAMANSEGSEAMLNRVMTKDNIGVTVLL 327

  Fly   351 KVKEN----AWEP--MSEVTQISQPLLVCTAHIHWDPEFCDVKLIQTMMLSNELKTIIDEASHSF 409
            ::.::    ..:|  .||    .|.|:|..||:|||||:.|||||||||..:|||:||::|:.
Frog   328 ELHKDLSGAGMKPHHSSE----KQLLMVANAHMHWDPEYSDVKLIQTMMFVSELKSIIEKAAS-- 386

  Fly   410 RPGHKN-DSNAVQLLLCGDFNSLPDSGVVEFLGKGRVSMDHLDFKDMGYKSCLQRLLSNDTN--- 470
            |||... |.|::..:||.|.||||||||||:|..|.|:.:|.|||::.|..||.....|..|
Frog   387 RPGSPTPDPNSIPFVLCADLNSLPDSGVVEYLTNGGVADNHKDFKELRYNECLTNFSCNGKNGTP 451

  Fly   471 --EFTHSFKLASAYNEDIMPHTNYTFDFKGIIDYIFYTKTGMVPLGLLGPVSNDWLRENKVVGCP 533
              ..||.|:|.|||..::||:|||||||||:||||||:||.|..||:|||:...|:.||.:.|||
Frog   452 DGRITHGFQLRSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMDVLGVLGPLDPQWMVENNITGCP 516

  Fly   534 HPHIP 538
            |||:|
Frog   517 HPHLP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR_4	74..114	CDD:289563	24/39 (62%)
		LRR_8	75..130	CDD:290566	36/54 (67%)
		leucine-rich repeat	76..98	CDD:275378	11/21 (52%)
		LRR_4	97..136	CDD:289563	29/38 (76%)
		leucine-rich repeat	99..121	CDD:275378	17/21 (81%)
		leucine-rich repeat	122..144	CDD:275378	17/21 (81%)
		leucine-rich repeat	145..156	CDD:275378	7/10 (70%)
		Deadenylase_CCR4	209..550	CDD:197331	200/342 (58%)
cnot6l	NP_001120421.1	leucine-rich repeat	33..52	CDD:275378	10/18 (56%)
		LRR_8	51..132	CDD:290566	53/80 (66%)
		LRR_4	51..91	CDD:289563	24/39 (62%)
		leucine-rich repeat	53..75	CDD:275378	11/21 (52%)
		leucine-rich repeat	76..90	CDD:275378	11/13 (85%)
		Deadenylase_CCR4b	186..521	CDD:197339	199/340 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I689
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H100830
Inparanoid	1	1.050	624	1.000	Inparanoid score	I856
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208223at33208
OrthoFinder	1	1.000	-	-		FOG0002437
OrthoInspector	1	1.000	-	-		oto102962
Panther	1	1.100	-	-	O	PTHR12121
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1441
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160