DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and HELZ

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_006722277.1	Gene:	HELZ / 9931	HGNCID:	16878	Length:	1970	Species:	Homo sapiens

Alignment Length:	1031	Identity:	216/1031 - (20%)
Similarity:	355/1031 - (34%)	Gaps:	283/1031 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QDENKLLQG------LEKSLKSLELQK-NEEYIECPPSERKCPPSEVGEYVMQHTRFSLTELTNA 68
            |:|||.|.|      :||.:.||..:| ..|.||....|.....|     |...|:.|....|.|
Human   225 QNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLS-----VTVSTKKSHQTWTFA 284

  Fly    69 LKMPAIDMFLYFLSDKRDLFENQ-----VLATDNVKRVGLFVDVLWSLCELELGG---------- 118
            |......| ||.::...|.....     :.|.|:..:|...|.   ..|:..:||
Human   285 LTCKPARM-LYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVP---ENCQEWIGGKMAQNGLDHY 345

  Fly   119 -------FDEVFLSAFSRQTALLD-KIKNLLQAKAAVAKCDAESALILSHSKWMLLRAHKH---- 171
                   |:......| |||.:.| .::.:|..:..:.....|....|.|:|..|:...|.
Human   346 VYKVGIAFNTEIFGTF-RQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSS 409

  Fly   172 --GLLSHQGYELVELYKKLAPSFKSDMIDGLEAFTGNFSHNVKGLIYPTLETLLGKDATKAPNEE 234
              .::..:..|..:|.|.|...::.. :...:.||               :::|.|..||:
Human   410 SKTIIDFEPNETTDLEKSLLIRYQIP-LSADQLFT---------------QSVLDKSLTKS---- 454

  Fly   235 EDEGLVSDKVVKYVNALRNLLREDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVHLTLNPQFAN 299
                       .|.:.|.:||       .:|.:.|.:..::........:|..|   |.|.....
Human   455 -----------NYQSRLHDLL-------YIEEIAQYKEISNTSGASTSRILLQD---TTNVTRGF 498

  Fly   300 AQRHSLVFLKVQFTKESKNAYKTWLNSIKSGTLLC----------LTTSLAFDD----LILASVG 350
            :....|..||||.    :......|..:..|....          ||.:|:.|.    |::..|.
Human   499 SCCSKLFNLKVQL----QILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVN 559

  Fly   351 --YTEP----------------------EKLKEDC---LSVQIVKQYNIGNAYNRPLIMFQAPVF 388
              |..|                      ||.||..   ||.:..::.|:     ||....|..:.
Human   560 AVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNL-----RPDCDTQVELQ 619

  Fly   389 FEPYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSFNMKPFTLDKLPEDLHLNES 453
            |:     .|.|..|... :.:.|...:|.:.  |...|.|.:..|.|.:   .|: ..|..||..
Human   620 FQ-----LNRLPLCEMH-YALDRIKDNGVLF--PDISMTPTIPWSPNRQ---WDE-QLDPRLNAK 672

  Fly   454 QKTAFKEALCREFSI------IQGPPGTGKTHLSVQLVNSLIQNAKALGTGPIIVLTYTNNSLDK 512
            ||.|.. |:....:|      |.||.|||||....|.|..::|..:   |..|::.|::|::.|.
Human   673 QKEAVL-AITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQE---TSRILICTHSNSAADL 733

  Fly   513 FLVKISRYTQEILRFGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYA 577
            :   |..|....:..||                 |:..|.|:             .|||
Human   734 Y---IKDYLHPYVEAGN-----------------PQARPLRV-------------YFRN------ 759

  Fly   578 NFDGSEESYQDTLAAQEKLNQVAER---IETLRMVFQFFLAREKDLLAMTTTCAARHNFLFRLL- 638
                         ...:.::.|..:   |.:....||  :.:::|:|        :|..:...|
Human   760 -------------RWVKTVHPVVHQYCLISSAHSTFQ--MPQKEDIL--------KHRVVVVTLN 801

  Fly   639 --QSKC-----------VLFEEAAEIQEAHIVACLTPHTEH--VILVGDHKQLQPFSGSRKVPQ- 687
              |..|           :|.:|||:..|...:..|...|::  ::|.|||.||.||..|....:
Human   802 TSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARER 866

  Fly   688 ---ISLFERL---IVAGLPFSRLNL--QYRMRSCISELLVPSIYD-ELLCSESVKEYEDIRLMSK 743
               :||.:||   ..|..| .|:.|  .||....|........|: :|:.|.....::|...::
Human   867 NLHVSLLDRLYEHYPAEFP-CRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLT- 929

  Fly   744 NLYFVQHNQPEHCMSDMSIGNLYEAGVLAKLTEFLIQK-----AQYKHSDIVILSPYNGQIECIK 803
              :|....:.....:..:..|..|...:.:..|.|.:|     .:.....|.:::||..|:..|:
Human   930 --FFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIR 992

  Fly   804 NALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSNISGR---------------------IGFLR 847
            ..|.:...|.|.|..|.:.||.:..::.||.||:..:.:                     .|||.
Human   993 AELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLS 1057

  Fly   848 QANRVCVALSRARWALYIVGNVTILKD--TFPKIWNPIVKRLKENNAI-GEAFPTI 900
            ....:..|::||:..:.:||:...|..  ...|.|...:....||::: |..|..|
Human  1058 NYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQI 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	56/254 (22%)
		AAA_19	467..>513	CDD:289986	17/51 (33%)
		UvrD_C_2	688..869	CDD:304668	45/212 (21%)
HELZ	XP_006722277.1	zf-CCCH	181..205	CDD:279036
		AAA_11	669..861	CDD:289831	58/257 (23%)
		P-loop_NTPase	669..>766	CDD:304359	33/152 (22%)
		DNA2	<785..1099	CDD:224037	70/325 (22%)
		UvrD_C_2	868..1079	CDD:304668	45/214 (21%)
		PHA03160	<1656..1815	CDD:165431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810