DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_017175214.1	Gene:	Zgrf1 / 71643	MGIID:	1918893	Length:	2044	Species:	Mus musculus

Alignment Length:	877	Identity:	205/877 - (23%)
Similarity:	344/877 - (39%)	Gaps:	202/877 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 VFLS-AFSRQ--TALLDKIKNLLQAKAAVAKCDAESALILS---HSKWMLLRAHKHGLLS---HQ 177
            ||.| |..||  ||.:.:..|:|..:.|.....|.|.:.:|   .||...:|:.|:...|   :|
Mouse  1209 VFQSPAHYRQVFTASIIEHLNILLFELAQRLYKALSKVDISFYTSSKGETMRSGKNNSPSCHHNQ 1273

  Fly   178 GYELVELYKKLAPSFKSDMIDGLEAFTGNFSHNVKGLIYPTLETLLGKDATKAPNEEEDEGLVSD 242
            ..:|| :.||..|:      .|...:|.:.|.:.:...:..||.:       .|.:.......|.
Mouse  1274 PAKLV-MVKKEGPN------KGRLFYTCDKSKDNQCKFFKWLEEV-------TPGQLPQNTSQST 1324

  Fly   243 KVVKYVNALRNLLREDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHSLVF 307
            .|...:.::.:.||...:....|....||.|.|. :.||.|.|  ....|:||.| .::..|.::
Mouse  1325 MVFNDIKSIGSYLRSQKVPVYEECQLLLRRGFDF-QRKQCGKL--KKLTTVNPDF-YSETKSKIY 1385

  Fly   308 LKVQFTKESKNAYKTWLNSIKSGTLLCLTTSLAFD-DLILASVGYTEPEKLKEDCL--------- 362
            ||:. .:||.:.|       ..|.|..::.:|.|: |..:|...:..|..:.|..|
Mouse  1386 LKLS-RRESSSVY-------SKGDLWVISKTLDFELDTFIACSAFFGPSSVNEVELLPLKGYFPS 1442

  Fly   363 ----------------SVQIVKQYNIGNAYN---RPLIMFQAPVFFEPYLRVHNYLSTCSTEKFP 408
                            |.::....||.:.:|   .||:         |||...:..:|.|::...
Mouse  1443 NWPTNITVHALLVCNASTELTTLQNIQDYFNPAALPLM---------PYLLAMSQSATVSSKNIS 1498

  Fly   409 MGRYIVDGQMEIPPPAYMKPGVKLSFNMKPFTLDKLPE--DLH-LNESQKTAF------------ 458
            ..::|        |||......|...::.. ||....|  ::| ||:.|.||.
Mouse  1499 KRKFI--------PPAITSIKTKTELHLGA-TLQLARELINVHRLNKDQATALIQIAQMMASQGS 1554

  Fly   459 -KEAL-----CREFSIIQGPPGTGKTHLSVQLVNSLIQNAKALGTG--------PIIVLTYTNNS 509
             ::||     ....::|.|..|.||::|...::..|::..:...:|        .::|.:.||.:
Mouse  1555 DEDALEPFGHSLPITVIHGVFGAGKSYLLAVVILFLVELFEKCDSGTVGNARPWKVLVSSSTNVA 1619

  Fly   510 LDKFLV-KISRYTQEILRFGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQ 573
            :|:.|: .:|...::.:|.|:..:            |...::|                     .
Mouse  1620 VDRVLLGLLSLGFEKFIRVGSVRK------------IAKPVLP---------------------Y 1651

  Fly   574 GLYANFDGSEESYQDTLA-AQEKLNQVAERIETLRMVFQFFLAREKDLL----AMTTTCAARHNF 633
            .|:|..|...|..::..| .:|:|..: ||:...:.:.|..|...:.||    .:..||||....
Mouse  1652 SLHAGSDNESEQLKELNALLKEELTPI-ERVYVRKSIEQHKLGTNRVLLKQVRVVGVTCAACAFP 1715

  Fly   634 LFRLLQSKCVLFEEAAEIQEAHIVACLTP----HTEHVILVGDHKQLQP-FSGSRKVP----QIS 689
            ....|:...|:.:|.:::.|.   |.|.|    ..|.:|||||.|||.| ..||....    :.:
Mouse  1716 CLNDLKFPVVVLDECSQMTEP---ASLLPIARFQCEKLILVGDPKQLPPTIQGSDAAHENGLEQT 1777

  Fly   690 LFERL-----------IVAGLPFS------------RLNLQYRMRSCISELLVPSIYD-ELLCSE 730
            ||:||           :.||....            .|..|||....||.:.....|: .|:...
Mouse  1778 LFDRLCLMACTSKMLQVTAGCRLCGWMKDEEGHKPVLLRTQYRCHPAISAIANDLFYEGSLVNGI 1842

  Fly   731 SVKEYEDIRLMSKNLYFVQHNQPEHCMSDMSIGNLYEAGVLAKLTEFLIQKAQYKHSDIVILSPY 795
            |.:|...:......|.|......|....:.|..|:.||....||.:.|:... .:...|.:::.|
Mouse  1843 SERERSPVLEWLPTLCFYNVTGAEQVERENSFVNVAEATFTLKLIQSLMASG-VESCMIGVITLY 1906

  Fly   796 NGQIECIKNAL-------PQNYRSTVQVASVDSFQGLEANIVLLSLVRSNISGRIGFLRQANRVC 853
            ..|:..|.|.|       |.  ...|||::||:|||.|..|.:||.||:.   ::||:....|:.
Mouse  1907 KSQMYKICNLLSAVDVGHPD--VKAVQVSTVDAFQGAEKEITILSCVRTR---QVGFIDSEKRMN 1966

  Fly   854 VALSRARWALYIVGNVTILKDTFPKIWNPIVK 885
            |||:|.|..|.|||:::.|:..  ::|..:::
Mouse  1967 VALTRGRRHLLIVGSLSCLRKN--RLWGRVIQ 1996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	60/267 (22%)
		AAA_19	467..>513	CDD:289986	12/53 (23%)
		UvrD_C_2	688..869	CDD:304668	59/211 (28%)
Zgrf1	XP_017175214.1	DUF2439	3..75	CDD:371019
		zf-GRF	1267..1311	CDD:284302	12/50 (24%)
		TIGR00376	<1568..2003	CDD:273041	115/474 (24%)
		AAA_12	1774..1981	CDD:372468	58/212 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810