DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6204 and setx

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_005161583.1	Gene:	setx / 562474	ZFINID:	ZDB-GENE-070402-1	Length:	2368	Species:	Danio rerio

Alignment Length:	1000	Identity:	203/1000 - (20%)
Similarity:	355/1000 - (35%)	Gaps:	353/1000 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLQG-LEKSLKSLELQKNEEYIECPPSER--KCPPSEVGEYVM-------QHTRFSLTELTNALK 70
            |.|| :.|.:.|.::....|    |||.:  :.|.:.|.:.|.       |..:|.|:.||.|:.
Zfish  1436 LPQGSVPKLVTSNKISSTSE----PPSYKVYQRPEAPVNKPVNKPMPTMDQSPKFDLSVLTQAIL 1496

  Fly    71 MPAIDMFLYFLSDKRDLFENQVLATDNVKRVGLFVDVLWSLCELELGGFDEV------FLSAFSR 129
            .                :|.::|  ||.|..|..:|    ||:|.|   .||      :|..|:.
Zfish  1497 K----------------WEYRML--DNYKAFGSPLD----LCQLPL---KEVPVNFSSYLEYFNT 1536

  Fly   130 QTALLDKIKNLLQAKAAVAKCDAESALILSHSKWMLLRAHKHGLLSHQGYELVELYKKLAPSFKS 194
            ...||     |:.|...:|            ::|:     |.|        .|:||.|
Zfish  1537 LYPLL-----LINAFEEMA------------NEWL-----KEG--------RVKLYLK------- 1564

  Fly   195 DMIDGLE--------AFTGNFSH--NVKGLIYPTLETLL--------GKDATKAPNEEEDEGLVS 241
              :.|:|        :|....|.  :|| .|||..:.|:        |..|...||
Zfish  1565 --VQGIEYSNRTASASFIAGLSQECDVK-QIYPKEDDLVLLWLPDNTGAYAQDEPN--------- 1617

  Fly   242 DKVVKYVNALRNLLREDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHSLV 306
                                                        :.|:|    |.|....|.::
Zfish  1618 --------------------------------------------FHDLH----PHFGYVSRSNV- 1633

  Fly   307 FLKVQFTKESKNAYKTWL------NSIKSGTLLCLTTSLAFDDLILASVGYTEPEKLKEDCLSVQ 365
               :..|..|::.....:      :|:.|..:||         .::.|:              :.
Zfish  1634 ---LNRTPGSRSTLNLTIQTRGNVSSVNSQPVLC---------EVVGSL--------------IS 1672

  Fly   366 IVKQYNIGNAYNRPLIMFQAPVFFEPYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKP-- 428
            |.:::       |.|.:.:......|.|..|....|.|          :||..::..|.:.:.
Zfish  1673 IFREF-------RALCLLRNGPMLRPLLAPHVSFFTHS----------LDGPSDLDAPEFNRDQA 1720

  Fly   429 -----GVKLSFNMKPFTLDKLPEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTH----LSVQL 484
                 |:.:                 ::..|||.       :|.:|.|||||||:.    |..:|
Zfish  1721 RAIACGIAM-----------------IHRKQKTP-------KFLLIHGPPGTGKSKTIGGLLYKL 1761

  Fly   485 VNSLIQNAKALGT-------GPIIVLTYTNNSLDKFLVKISRYTQE----------------ILR 526
            ::|...::..:|.       ..:::...:|.::|..:.|:....:|                ::|
Zfish  1762 LSSATNSSATVGNLHSKSRRTRVLLCAPSNAAIDSLMKKVILIFKEKCRNINAPQGNCGDINLVR 1826

  Fly   527 FGNQSRDPQISKFNLSTTIKP----ELVPPRLKRIWWLVNCEYKEKFRNLQGLYAN--------- 578
            .||:.        .:|.::||    .....|.:|....|..:...:...|..:..|
Zfish  1827 LGNER--------TISKSLKPFSLDHQTKARAQRAQQTVESDVHRRKEQLDQMIENLSHQCAKTQ 1883

  Fly   579 -----FDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLLAMTTTCAAR---HNFLF 635
                 |....|..:..|..:|.|::..:.....|...|..:.:...::..|.:.:..   .|...
Zfish  1884 KNSTEFKNLLEQKKQFLKEREGLSRQIKECRGRRQESQALVLQNAHVICCTLSTSGSIVLENAFR 1948

  Fly   636 RLLQS--KCVLFEEAAEIQEAHIVACLTPHTEHVILVGDHKQLQPFSGSRKVPQISLFERLIVAG 698
            ||...  .||:.:||::.:|...:..:......||||||..||.|...|:|..:.. |::.::|.
Zfish  1949 RLGHEPFSCVIIDEASQAKETETLIPMLYRCPSVILVGDPNQLPPTVVSQKAKEFG-FDQSLMAR 2012

  Fly   699 L------------PFSRLNLQYRMRSCISELLVPSIYDELL----------CSES--VKEYE--- 736
            |            |...|::||||...|.|.....||:..|          ||.|  .|.|:
Zfish  2013 LCKSLHPSNSKLPPILLLSMQYRMHPDICEFPSKYIYNSALKNDCETAQKRCSLSWPFKPYKVFD 2077

  Fly   737 --DIRLMSKNLYFVQHNQPEHCMSDMSIGNLYEAGVLAKLTEFLIQKAQYKHSDIVILSPYNGQI 799
              |.|...:...|:.|       .::|:     .|:|.|    |:.|.|...  :.:::|||.|.
Zfish  2078 VMDGRETKERDSFINH-------KEVSL-----VGLLLK----LLCKEQAVR--VGVITPYNAQK 2124

  Fly   800 ECIKNALPQ---NYRSTVQVASVDSFQGLEANIVLLSLVR-SNISGRIGFLRQANRVCVALSRAR 860
            ..|.:|:..   |.:..|:|.:||.|||.|.:.:::|.|| |:..|.|||:....|:.|.::||:
Zfish  2125 HRILDAIKTSGINKQLQVEVDTVDGFQGREMDCIIVSCVRASSEMGSIGFVGNRQRMNVTITRAK 2189

  Fly   861 WALYIVGNVTILKDTFPKIWNPIVK 885
            ::|:|:|::..|::  ...|..:::
Zfish  2190 FSLFILGHLRTLRE--QSDWGALIE 2212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	55/279 (20%)
		AAA_19	467..>513	CDD:289986	14/56 (25%)
		UvrD_C_2	688..869	CDD:304668	60/213 (28%)
setx	XP_005161583.1	SEN1_N	37..>322	CDD:289496
		AAA_11	1714..1998	CDD:289831	57/315 (18%)
		AAA_12	2005..2197	CDD:289832	59/209 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810