DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and helz2a

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_003198895.2	Gene:	helz2a / 562461	ZFINID:	ZDB-GENE-120920-1	Length:	2656	Species:	Danio rerio

Alignment Length:	844	Identity:	203/844 - (24%)
Similarity:	320/844 - (37%)	Gaps:	243/844 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 KCDAESALILSHSKWMLLRAHKHGLLSHQGYELVELYKKLAPSFKSDMIDGLEAFTGNFSHNVKG 213
            ||.:|.||..|.|.:                   .|||                       :.:.
Zfish  1938 KCFSEYALSSSRSSY-------------------NLYK-----------------------DYQA 1960

  Fly   214 LIYPTLETLLGKDATKAPNEEEDEGLVSDKVVKYVNALRNLLREDFLAPLVEFVQQLRSGTDVDE 278
            :..|..|.   :.|:.|..|.|.. |:.|..:|:.|:....|:..||.||              :
Zfish  1961 IWRPMCEM---ESASSAVAENESI-LIVDVPLKWENSNPKRLQGFFLLPL--------------D 2007

  Fly   279 LKQQGLLWS-DVHLTLNPQFANAQRHSLVFLKVQFTKES----KNAYKTWLNSIKSGTLLCLTTS 338
            .|.|   || |..|          |:|.:.::.:..|:|    ::|..|.|..|.|.|.:.....
Zfish  2008 KKSQ---WSIDCDL----------RNSFLCIRTRIQKQSSPFLESAQNTALMDIPSFTWVVHGVI 2059

  Fly   339 LAFDDLILASVGYTEPEKLKEDCLSVQIVKQYNIGNAYNRPLIMFQAPVFFE------------- 390
            ...::.........||:.|:.|.|            ..:.|:......:|.|
Zfish  2060 TEAEETESKESTNQEPKSLRIDFL------------INHMPMTNIPEQIFHERTRFTLELIPKLL 2112

  Fly   391 PYLRVHNYLSTCS-----TEKFPMGRYIV-DGQMEIPPPAYMKPGVKLSFNMKPFTLDKL-PEDL 448
            |.:|..|.:.:.:     .:...|||.|. |...:||           :.|...|.::.. |..|
Zfish  2113 PDVRKENAIDSLTKANQLVKNIAMGRRITSDRGCKIP-----------NQNTGRFEINSYHPSGL 2166

  Fly   449 -HLNESQKTAFKEALCREFSIIQGPPGTGKTHLSVQLVNSL---IQNAKALGT--------GPII 501
             |||.||..|.:|||...|::||||||||||.:.|.::..|   ||..:|.|:        ||
Zfish  2167 SHLNNSQSKAIREALTNPFTLIQGPPGTGKTVVGVHILYWLHKNIQQLQASGSKKRAILYCGP-- 2229

  Fly   502 VLTYTNNSLD----------KFLVKISRYT--QEILRFGNQSRDPQISKFNLSTTIKP--ELVPP 552
                :|.|:|          ..|..:..|:  .|:|.|.....:.::|: |.....||  ||...
Zfish  2230 ----SNKSVDVVAGHLLHLRDHLKPLRVYSDQMEMLEFPYPGCNLKLSR-NSKRGEKPNTELSSI 2289

  Fly   553 RLKRIWWLVNCEYKEKFRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFL--A 615
            .|..:                   ...:|:..|.| ..|...|:.:..:..:..|.:|:..|  |
Zfish  2290 ALHHL-------------------IRKEGNPFSTQ-IRAFDMKVQRGDQLTDEERKLFREILKKA 2334

  Fly   616 REKDLL---AMTTTC-AARHNFLFRLLQSKCVLFEEAAEIQEAHIVACLTPH-TEHVILVGDHKQ 675
            |:.:||   .:..|| ||.|..|...|..|.::.:|.|...|......|..| .|.::|:|||||
Zfish  2335 RKHELLHHDVILCTCTAASHPALAETLDFKQIIIDECAMATEPEAFIPLVAHKPEQIVLLGDHKQ 2399

  Fly   676 LQPFSGSRKVPQI----SLFERLIVAGLPFSRLNLQYRMRSCISELLVPSIYDELLCSESVKEYE 736
            |||........::    |||||.:...|   .|:.||||:             |.:|:....|:.
Zfish  2400 LQPVVHCEVAERLGMSRSLFERYMENAL---MLDTQYRMQ-------------EDICAFPSNEFY 2448

  Fly   737 DIRLMS-----KNLYFVQHNQPEHCM-------------------SDMSIGNLYEAGVLAKLTEF 777
            ..||.:     ..|:..|..|.  |:                   ::.|..|:.||..:.::. .
Zfish  2449 GGRLQTGIPAKSKLFLTQTKQT--CIVFGHVEGKEKSLVVRTEQGNENSKANMEEAEEVVRVA-I 2510

  Fly   778 LIQKAQYKHSDIVILSPYNGQIECIKNALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSN---- 838
            |:.:|..|..||.||:|||.|:..|..:|..|:...:.|.::...||.|...|::|.|||.
Zfish  2511 LLTEAGIKTKDIAILTPYNAQVAKISESLHNNHIRDITVNTIMRSQGSEWRYVIMSTVRSCPKSE 2575

  Fly   839 ---------ISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNAI 893
                     |..|:||:...::|.|.::||:..|.|:||..:|:.:  .:|..::...:|...:
Zfish  2576 IETQPPKSWIMKRLGFITDPHQVNVGITRAQEGLCIIGNENLLRCS--SLWRKLLNHYQEKGCV 2637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	77/261 (30%)
		AAA_19	467..>513	CDD:289986	21/66 (32%)
		UvrD_C_2	688..869	CDD:304668	58/221 (26%)
helz2a	XP_003198895.2	AAA_11	614..807	CDD:289831
		P-loop_NTPase	639..>683	CDD:304359
		DNA2	<741..1055	CDD:224037
		UvrD_C_2	817..1017	CDD:304668
		RNB	1338..1698	CDD:214935
		AAA_11	2168..2405	CDD:289831	78/263 (30%)
		AAA_19	2176..2246	CDD:289986	26/75 (35%)
		P-loop_NTPase	<2366..2438	CDD:304359	26/87 (30%)
		AAA_12	2414..2614	CDD:289832	57/218 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810