DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6204 and ZGRF1

DIOPT Version :9

Sequence 1:NP_651229.2 Gene:CG6204 / 42877 FlyBaseID:FBgn0039165 Length:903 Species:Drosophila melanogaster
Sequence 2:NP_060862.3 Gene:ZGRF1 / 55345 HGNCID:25654 Length:2104 Species:Homo sapiens


Alignment Length:963 Identity:227/963 - (23%)
Similarity:370/963 - (38%) Gaps:200/963 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 EKSLKSLELQKNEEYIECPPSERKCPPSEVGEYVMQHTRFSLTELTNALKMPAIDMFLYFLSDKR 85
            |.||.|:.||..:                 |....|...||..:..:..|:.::::         
Human  1194 ESSLDSVHLQMIK-----------------GMLYQQRQDFSSQDSVSRKKVLSLNL--------- 1232

  Fly    86 DLFENQVLATDNVKRV-GLFVDVLWSLCEL-ELGGFDEVFLSAFSRQTALLDK----IKNLLQA- 143
                .|...|:.:|.| |......:|:.:| |:.|.:..|.|....::|.|.:    |..:.|: 
Human  1233 ----KQTSKTEEIKNVLGGSTCYNYSVKDLQEISGSELCFPSGQKIKSAYLPQRQIHIPAVFQSP 1293

  Fly   144 ---KAAVAKCDAESALILSHSKWMLLRAHKHGLLSHQGYELVELYKKLAPSFKSDMIDGLEAFTG 205
               |.....|      ::.|...:|.     ||..:....|.::......|.|.:.:...|....
Human  1294 AHYKQTFTSC------LIEHLNILLF-----GLAQNLQKALSKVDISFYTSLKGEKLKNAENNVP 1347

  Fly   206 NFSHNV-------------KGLIYPTLETLLGKDATK----------APNEEEDEGLVSDKVVKY 247
            :..|:.             ||.::.|.:   |..|.:          .|.....||.....|:..
Human  1348 SCHHSQPAKLVMVKKEGPNKGRLFYTCD---GPKADRCKFFKWLEDVTPGYSTQEGARPGMVLSD 1409

  Fly   248 VNALRNLLREDFLAPLVEFVQQL-RSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHSLVFLKVQ 311
            :.::...||...: ||.|..|.| |.|.|. :.||.|.|  ....|:||:|.|..:..| :||:.
Human  1410 IKSIGLYLRSQKI-PLYEECQLLVRKGFDF-QRKQYGKL--KKFTTVNPEFYNEPKTKL-YLKLS 1469

  Fly   312 FTKESKNAYKTWLNSIKSGTLLCLTTSLAFD-DLILASVGYTEPEKLKE-DCLSVQ--------- 365
             .||..:||       ....|..::.:|.|: |..:|...:..|..:.| :.|.::         
Human  1470 -RKERSSAY-------SKNDLWVVSKTLDFELDTFIACSAFFGPSSINEIEILPLKGYFPSNWPT 1526

  Fly   366 --IVKQYNIGNAYNRPLIMFQAPVFFEP-YLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMK 427
              :|....:.||......:.....:|.| .|.:..||.|.|:......:.:  .:.:..|||:..
Human  1527 NMVVHALLVCNASTELTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRV--SKRKFIPPAFTN 1589

  Fly   428 PGVKLSFNMKPFTLDKLPEDL----HLNESQKTAF----------------KEALCREF--SIIQ 470
            ...|........|| ||..:|    .||:.|.||.                ||.....|  :||.
Human  1590 VSTKFELLSLGATL-KLASELIQVHKLNKDQATALIQIAQMMASHESIEEVKELQTHTFPITIIH 1653

  Fly   471 GPPGTGKTHLSVQLVNSLIQ-----NAKALGTG---PIIVLTYTNNSLDKFLVKISRYTQEILRF 527
            |..|.||::|...::...:|     .|..:|..   .:::.:.||.::|:.|:.:..     |.|
Human  1654 GVFGAGKSYLLAVVILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGLLS-----LGF 1713

  Fly   528 GNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYANFDGSEESYQDTLAA 592
            .|..|...:.|.     .|| ::|                     ..|:|..:...|..::..|.
Human  1714 ENFIRVGSVRKI-----AKP-ILP---------------------YSLHAGSENESEQLKELHAL 1751

  Fly   593 QEKLNQVAERIETLRMVFQFFLAREKDLL----AMTTTCAARHNFLFRLLQSKCVLFEEAAEIQE 653
            .::.....||:...:.:.|..|...:.||    .:..||||........|:...|:.:|.::|.|
Human  1752 MKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQITE 1816

  Fly   654 AHIVACLTP----HTEHVILVGDHKQLQP-FSGSRKVP----QISLFERLIVAGLPFSRLNLQYR 709
            .   |.|.|    ..|.:|||||.|||.| ..||....    :.:||:||.:.|.....|..|||
Human  1817 P---ASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYR 1878

  Fly   710 MRSCISELLVPSIYDELLCSESVKEYEDIRLMS--KNLYFVQHNQPEHCMSDMSIGNLYEAGVLA 772
            ....||.:.....|...|.: .|.|.|...|:.  ..|.|......|....|.|..|:.||....
Human  1879 CHPAISAIANDLFYKGALMN-GVTEIERSPLLEWLPTLCFYNVKGLEQIERDNSFHNVAEATFTL 1942

  Fly   773 KLTEFLIQKAQYKHSDIVILSPYNGQIE--C-IKNALPQNYR--STVQVASVDSFQGLEANIVLL 832
            ||.:.||... ...|.|.:::.|..|:.  | :.:|:..::.  .||||::||:|||.|..|::|
Human  1943 KLIQSLIASG-IAGSMIGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQVSTVDAFQGAEKEIIIL 2006

  Fly   833 SLVRSNISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVK 885
            |.||:.   ::||:....|:.|||:|.:..|.||||:..|:..  ::|..:::
Human  2007 SCVRTR---QVGFIDSEKRMNVALTRGKRHLLIVGNLACLRKN--QLWGRVIQ 2054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6204NP_651229.2 AAA_11 449..679 CDD:289831 62/264 (23%)
AAA_19 467..>513 CDD:289986 13/53 (25%)
UvrD_C_2 688..869 CDD:304668 61/187 (33%)
ZGRF1NP_060862.3 AAA_11 1614..1844 CDD:289831 62/264 (23%)
DNA2 <1739..2057 CDD:224037 96/326 (29%)
AAA_12 1855..2039 CDD:289832 60/188 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2085..2104
DUF2439 4..73 CDD:287368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..359
zf-GRF 1347..1391 CDD:284302 6/46 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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