DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and MOV10

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_001123551.1	Gene:	MOV10 / 4343	HGNCID:	7200	Length:	1003	Species:	Homo sapiens

Alignment Length:	845	Identity:	183/845 - (21%)
Similarity:	286/845 - (33%)	Gaps:	244/845 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LRAHKHGLLSHQGYELVELYKKLAPSFKSDMIDGLEAFTGNFSHNVK---------------GLI 215
            |.|..|..|:.|       .|.:.| ||...|.|....|.......:               |..
Human   238 LAAVAHSPLAAQ-------LKPMTP-FKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTY 294

  Fly   216 Y--PTLETLL-----GKDATKAPNEEEDEGLVSDKVVKYVN---ALRNLLREDFLAPLVEFVQQL 270
            |  |.|..||     |.....||.|..:.....:..:|:.|   .||.||.          :::|
Human   295 YPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLH----------LEEL 349

  Fly   271 RSGTDVD--ELKQQGLLWSDVH-----LTLNPQFANAQR-------HSLVFLKVQFTKESKNAYK 321
            :...|:.  :|:...:.|..|.     |||........|       |....|..:..:|....||
Human   350 QMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYK 414

  Fly   322 TWLNSIKSGTL-LCLTTSL--AFDDLILASVGYTEPEKLKEDCLSVQIVKQYNIGNAYNRPLIMF 383
            .:::.::...: |..:.||  .|.|.:...|.:|                       :||
Human   415 GFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFT-----------------------FNR----- 451

  Fly   384 QAPVFFEPYLRV-HNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSFNMKPFTLDKLPED 447
                  :| ||| |..|..       .||:::               ..:.|.:.|..:..||.|
Human   452 ------QP-LRVQHRALEL-------TGRWLL---------------WPMLFPVAPRDVPLLPSD 487

  Fly   448 LHL---------NESQKTAFKEALCREFS----IIQGPPGTGKTHLSVQLVNSLIQNAKALGTGP 499
            :.|         |..|..|.:..:.....    ||.||||||||   |.||.::.|..|.|....
Human   488 VKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKT---VTLVEAIKQVVKHLPKAH 549

  Fly   500 IIVLTYTNNSLDKFLVKIS-RYTQEILRFGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNC 563
            |:....:|:..|....::. .....|.|....|||         ..:.||.:.|          |
Human   550 ILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRD---------IRMVPEDIKP----------C 595

  Fly   564 EYKEKFRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLLAMTTTCA 628
                         .|:|..:..|  ...|::||.:....|.||....:...|:
Human   596 -------------CNWDAKKGEY--VFPAKKKLQEYRVLITTLITAGRLVSAQ------------ 633

  Fly   629 ARHNFLFRLLQSKCVLFEEAAEIQEAHIVACLTPHTE---------HVILVGDHKQLQPFSGSRK 684
                  |.:.....:..:||....|...:..:....|         .::|.||.:||.|...|..
Human   634 ------FPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPL 692

  Fly   685 VPQ----ISLFERLIVAGLPF------------SRLNLQYRMRSCISELLVPSIYDELL--CSES 731
            ..:    .||.|||:.....:            ::|...||....|.::.....|:..|  |::.
Human   693 TQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADV 757

  Fly   732 VKEYEDIR---LMSKNLYFVQH---NQPEHCMSDMSIGNLYEAGVLAKLTEFLIQ------KAQY 784
            |......|   |..:....:.|   .:.|...:..|..|..||..:....:.|:.      ||:.
Human   758 VDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARL 822

  Fly   785 KHSDIVILSPYNGQIECIKNALPQNYR--------STVQVASVDSFQGLEANIVLLSLVRS---- 837
            ....:.::|||..|:|.|:..:.:..|        ..::|.||:.|||.|.:::|:|.|||
Human   823 SPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSF 887

  Fly   838 ---NISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNA-IGEAFP 898
               ::...:|||:...|..||::||:..|.||||..:|... |. |...::..|||.. .|..||
Human   888 VQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHD-PD-WKVFLEFCKENGGYTGCPFP 950

Fly 899 898
Human 951 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	52/252 (21%)
		AAA_19	467..>513	CDD:289986	19/49 (39%)
		UvrD_C_2	688..869	CDD:304668	55/221 (25%)
MOV10	NP_001123551.1	DEXXQc_Helz-like	498..733	CDD:350796	59/289 (20%)
		DEAG box	645..648		1/2 (50%)
		SF1_C_Upf1	734..939	CDD:350195	51/206 (25%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269\|PubMed:22791714	921..965		10/32 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..1003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810