DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and CG7504

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster

Alignment Length:	1020	Identity:	222/1020 - (21%)
Similarity:	374/1020 - (36%)	Gaps:	291/1020 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QDENKLLQGLEKSLKSLELQKNEEYIECPPSERKCPPSEVGEYVMQHTR---FSLTELTNALKMP 72
            :::.||.:...::||.|..:..|.......::||.|.|..   .:|:|.   |    ||..:..|
  Fly   766 KEDEKLKECRREALKKLSEKPKENSHRSTTNKRKNPTSVP---TVQNTNRGGF----LTKGVDGP 823

  Fly    73 AIDMFLYFLSDKRDLFENQVLATDNVK--------RVGLFVDVLWSLCELELGGFDEVFLSAFSR 129
            |                .::..|||.|        :                   ....:..||:
  Fly   824 A----------------PKLAKTDNAKPPPKKPVPK-------------------QPPAIETFSQ 853

  Fly   130 QTALLDK--IKNLLQAKAAVAKCDAESA-------------LILSHSKWMLLRAHKHGLLSHQGY 179
            |....||  :....|....|.:.:||.|             :.|.|.|               ..
  Fly   854 QLQAADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQK---------------AE 903

  Fly   180 ELVELYKKLAP-SFKSDM-IDGLEAFTGNFSHNVKGLIYPTLETLLGKDATK---APNEEEDEGL 239
            :..:|.|||.. .|..|: :..:|...| .|..|:|          .|:..|   :...|..|.:
  Fly   904 DSKKLQKKLRKVHFNDDVKVHCIERVKG-ASSKVQG----------RKECIKLRLSSYRERREWI 957

  Fly   240 VSDKVVKYVNALRNLLREDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHS 304
            ..:.  |.||.:|...|.     ::::..|......||.:.:|     ||.:.:.|:|.:.:.:.
  Fly   958 RREN--KPVNDIRQHSRS-----ILKWANQWLKHGSVDAVAEQ-----DVLMPIPPEFDSFKNYR 1010

  Fly   305 LVFLKV-----------QFTKESKNAYKTWLNSIKSG----TLLCLTTSLAFDDLILASV---GY 351
            .:|:.:           .:...:||.:...|.::::.    .|:....|..|...:|.::   |
  Fly  1011 EIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCG- 1074

  Fly   352 TEPEKLKEDC---------------LSVQIVKQ-------YNIGNAYNRPLIMFQAPVFFEPYLR 394
                .|||..               |:.:|:||       .||.....||::         ..||
  Fly  1075 ----MLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVV---------DSLR 1126

  Fly   395 --------VHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGV---KLSFNMKPFT------LD 442
                    ||...|:      |:.|.|            :||..   ::|...:|||      |:
  Fly  1127 VELGALSAVHQLRSS------PLCRRI------------LKPTQTVNEVSLPKQPFTFKGCHKLN 1173

  Fly   443 KLPEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTHLSVQL-VNSLIQNAKALGTGPIIVLTYT 506
            :..|::.|:..|:..  :.|....::|||||||||:.:..:| :.:|..||.......|::..::
  Fly  1174 EHQENIVLHTYQRII--DDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHS 1236

  Fly   507 NNSLD-------KFLVKISRYTQEILRFGNQSRDPQISK-------FNLSTTIKPELVPPRLKRI 557
            |.::|       ..|..::|....:||||...:....|:       ||.:...|.:.|...
  Fly  1237 NTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKE---- 1297

  Fly   558 WWLVNCEYKEKFRNLQGLYANFDGSEESYQ----DTLAAQEKLNQVAERIETLRMVFQFFL--AR 616
                |.|..:|..|        |..:|..|    ..|.:...|.|:.::.:.|:::.....  ..
  Fly  1298 ----NAEILKKQHN--------DLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLT 1350

  Fly   617 EKDLLAMTTTCAARHNFLFRLLQSKCVLFEEAAEIQEAHIV----ACLTPHT--------EHVIL 669
            :::...::..|..|.|.:...| |.||......:..:..||    .|..|.|        .|::|
  Fly  1351 QREEFEISHMCVTRANIICTTL-SSCVKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVL 1414

  Fly   670 VGDHKQLQPFSGSRKVPQI----SLFERL-----IVAGLPFS---------RLNLQYRMRSCISE 716
            |||.:||.....|:|....    |:|:|:     .....|.|         :|:.||||...|..
  Fly  1415 VGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICR 1479

  Fly   717 LLVPSIY---DELLCSESVKEYEDIRLMSKNLYFVQHNQPEHCMS----DMSIGNLYEAGVLAKL 774
            .  |:.|   |:|:.:|..     .|..|..:.:...|....|.|    :.||.|..||..:|||
  Fly  1480 W--PNQYFYEDQLINAECT-----ARFASPLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKL 1537

  Fly   775 TEFLIQKAQYKHSDIVILSPYNGQIECIKNALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSNI 839
            ...:.:....|.....::|||..|...:...:|.:...|.|  :|||:||||.:::::|..|:.
  Fly  1538 LTEMDKHMPSKRFSYGLISPYQNQCYALSQVIPSHMNITPQ--TVDSYQGLEKDVIIISNARTR- 1599

  Fly   840 SGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIV 884
              ..|||....|:.|||:|.|..|.|.||...||..  ::|..::
  Fly  1600 --GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSV--EMWRNLL 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	60/262 (23%)
		AAA_19	467..>513	CDD:289986	16/53 (30%)
		UvrD_C_2	688..869	CDD:304668	58/205 (28%)
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	62/275 (23%)
		AAA_19	1194..1251	CDD:289986	16/56 (29%)
		YtxH	<1293..1347	CDD:295162	12/69 (17%)
		AAA_12	1435..1626	CDD:289832	57/202 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840