DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Setx

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_006233948.1	Gene:	Setx / 362096	RGDID:	1565575	Length:	2702	Species:	Rattus norvegicus

Alignment Length:	936	Identity:	188/936 - (20%)
Similarity:	331/936 - (35%)	Gaps:	292/936 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 TGNFSHNVKGLIYPTLETLLGKDATKAPNE---EEDEGLVSDKVVKYVNALRNLLREDFLAPLVE 265
            |.|.|   |.|...||::.|...::.|.:.   .....|.|.|.|..|.:|.|:..  |..|...
  Rat  1590 TANLS---KSLESTTLQSALKNKSSGAQSNLKMTPSSSLGSQKPVAEVKSLCNIFH--FQTPSSS 1649

  Fly   266 FVQQLR------------SGTDV--------DELKQQGLLWSDVHLTLN---------------- 294
            ..|..:            |..|:        |...::.|.|. ..:.||
  Rat  1650 SKQSYKFTFSENRPASAASSVDILLPSQSIFDTFIKEVLKWK-YQMFLNFDKCGAPTSLCQSISR 1713

  Fly   295 ---PQFANAQRHSLVFLKVQFTKESKNAYKTWLNSIKSGT-------------------LLCLTT 337
               .:|.:...:..|||.:......:...:.||||.....                   |:.|..
  Rat  1714 PVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLNSPNKENFYQLHLRKFPADYKKYWEFLIYLEE 1778

  Fly   338 S-LA------FDDLILASVGYTEPEKLKEDCLSVQIVKQYNIG--NAYNRPLIMFQA-------- 385
            | ||      .:||:     :..|||...|..|||....|..|  :.:.|..:|...
  Rat  1779 SELAKQLHPKENDLV-----FLVPEKKYMDRHSVQDRSHYYCGYVHKFRRTSVMRSGKTECSLCI 1838

  Fly   386 ------PVFFEPYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSFNMKPFTLDKL 444
                  |...:...:.....|..:|::......::.|:.::....           :.|..:|..
  Rat  1839 QTQDNMPASVKELTKCIVISSLVTTQRKLKAMSLLSGRNQLARAV-----------LNPNPMDFC 1892

  Fly   445 PEDL-------------HLNESQKTAFKEALC--------REFSIIQGPPGTGKTHLSVQLVNSL 488
            .:||             ..||.||.|.:.|..        .:..:|.|||||||:...|.|:..|
  Rat  1893 TKDLLTTTSERIIAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRL 1957

  Fly   489 IQNAKALG-----------TGPIIVLTYTNNSLDKFLVKISRYTQE----------------ILR 526
            :..::..|           ...::|...:|.::|:.:.||....:|                ::|
  Rat  1958 LTESQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVR 2022

  Fly   527 FG-NQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYANFD---------- 580
            .| .:|.:.::.||:|.:.     |..|:|:.   :....:|..|..:.|.|..|
  Rat  2023 LGPEKSINTEVLKFSLDSQ-----VSHRMKKD---LPSHIQEMLRRKEILDAQLDELSRQRALCR 2079

  Fly   581 -GSEESYQD-----TLAAQEKLNQVAERIETLRMVFQFFLAREKDLLAMTTTCAARHNFLFRLLQ 639
             |.|...|:     .:.::|: .::|.:|:.::...|  .|:...:|.....|.........||:
  Rat  2080 GGREMQRQELDEHIVIVSKER-QELASKIKEVQGRPQ--RAQNTIILESHVICCTLSTSGGLLLE 2141

  Fly   640 S----------KCVLFEEAAEIQEAHIVACLTPHTEHVILVGDHKQLQPFSGSRKVPQISL---- 690
            |          .||:.:||.:..|...::.|......::||||.|||.|...|.|..:...
  Rat  2142 SAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLVLVGDPKQLPPTVISMKAQEYGYDQSM 2206

  Fly   691 -----------FERLIVAGLPFSRLNLQYRMRSCISELLVPSIY------------DELLCS--- 729
                       .|:.::..||..:|.:||||...|  .|.||.|            :.:.||
  Rat  2207 MARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDI--CLFPSNYVYNKNLKTNRLTETIRCSSEW 2269

  Fly   730 -------------------ESVKEYEDIRLMSKNLYFVQHNQPEHCMSDMSIGNLYEAGVLA--K 773
                               :|....::|:|:.:.:..::..:     .|:|..|:   |::.  |
  Rat  2270 PFQPYLVFDVGDGSEQRDNDSYINVQEIKLVMEIIKLIKEKR-----KDISFRNI---GIITHYK 2326

  Fly   774 LTEFLIQKAQYKHSDIV-ILSP----------------YNGQIECIKNALPQNYRSTV------- 814
            ..:.:|||...|..|.. :|.|                .....||: :|..:...|||
  Rat  2327 AQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSECM-HASDELDSSTVTQSGISS 2390

  Fly   815 -----------QVASVDSFQGLEANIVLLSLVR-SNISGRIGFLRQANRVCVALSRARWALYIVG 867
                       :|.:||:|||.:.:.::::.|| |.:.|.||||....|:.|.::||:::|:|:|
  Rat  2391 LENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILG 2455

  Fly   868 NVTILKDTFPKIWNPIVKRLKENNAI 893
            ::..|.:.  :.|..:::..::..||
  Rat  2456 HLRTLMEN--QHWYELIQDAQKRGAI 2479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	64/291 (22%)
		AAA_19	467..>513	CDD:289986	15/56 (27%)
		UvrD_C_2	688..869	CDD:304668	57/267 (21%)
Setx	XP_006233948.1	SEN1_N	37..>356	CDD:289496
		AAA_11	1910..2195	CDD:289831	65/295 (22%)
		AAA_19	1934..>1997	CDD:289986	15/62 (24%)
		AAA_12	2202..2456	CDD:289832	56/264 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910