Protein Alignment CG6204 and Dna2

DIOPT Version :9

• Sequence 1: NP_651229.2
• Gene: CG6204 / 42877
• FlyBaseID: FBgn0039165
• Length: 903
• Species: Drosophila melanogaster
• Sequence 2: NP_796346.2
• Gene: Dna2 / 327762
• MGIID: 2443732
• Length: 1062
• Species: Mus musculus
• Alignment Length: 971
• Identity: 212/971 - (21%)
• Similarity: 367/971 - (37%)
• Gaps: 290/971 - (29%)

  Fly    75 DMFLYFLSDKRDLFENQVLATDNVKRVGLFVDVLWSLCELELGGFDEVFLSAFSR---------- 129
            ::.|..|.:.|.|.|        :.|:.|..|.:  |||:      |.:|.:||:
Mouse   182 ELALQTLREVRHLKE--------MYRLNLSQDEI--LCEV------EEYLPSFSKWAEDFMRKGP 230

  Fly   130 -------QTALLDKIKNLLQAKAAVAKCDAESALILSHSKWMLLRAHKHGLLSHQGYEL-VELYK 186
                   |.:|.....|    :::....:...:|.:..|.|    :.:.||.......: |::::
Mouse   231 SSEFPQMQLSLPSDGSN----RSSPCNIEVVKSLDIEESIW----SPRFGLKGKIDVTVGVKIHR 287

  Fly   187 KLAPSFKSDMIDGLEAFTGNFSHNVK-----------------------------GLIYPT---- 218
            .....:|   :..||..||..|::::                             |.:||.
Mouse   288 DCKMKYK---VMPLELKTGKESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANH 349

  Fly   219 -------------LETLLGKDATKAPNEEE-----DEGLVSDKVVKYVNALRNLLREDFLAPLVE 265
                         ..:||.:.:..||.||.     .:.:..:|..||.:.:.|      .|....
Mouse   350 LDKRELLKLRNWLAASLLHRVSRAAPGEEARLSALPQIIEEEKTCKYCSQIGN------CALYSR 408

  Fly   266 FVQQLRSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHSLVFLKVQFTKESKNAYKT----WLNS 326
            .|::......:.|.....:.....||    |.|:.:..||..|.:....:||:..||    ||..
Mouse   409 AVEEQGDDASIPEAMLSKIQEETRHL----QLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTP 469

  Fly   327 I----KSG------------TLLC----------------LTTSLAFDDLILASVGYTEPEKLKE 359
            .    :||            :.:|                .|..:|.|.:||:.      |:.|.
Mouse   470 ASELEESGNCVGNLVRTEPVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIILSG------EERKL 528

  Fly   360 DCLSVQIVKQYN---IGNAYNRPLIMFQAPVFFEPYLRV-----HNYLSTCSTEKFPMGRYIVDG 416
            ..||...||:.|   :....:|.|....|...|    |:     |..:||      |:|.  :..
Mouse   529 FALSKGYVKKMNKAAVTCLLDRNLSTLPATTVF----RLDREERHGDIST------PLGN--LSK 581

  Fly   417 QMEIPPPAYMKPGVKLSFNMKPFTL---DKLPEDLH---------LNESQKTAFKEA-LCREFSI 468
            .||...|:.....:.:.|....|..   ..||.|..         ||:.|:.|.|.. |.:::::
Mouse   582 LMESTDPSKRLRELIIDFREPQFIAYLSSVLPHDAKDTVANILKGLNKPQRQAMKRVLLSKDYTL 646

  Fly   469 IQGPPGTGKTHLSVQLVNSLIQNAKALGTGPIIVLTYTNNSLDKFLVKISRYTQEILRFGNQSR- 532
            |.|.||||||    ..:.:|::...|.|.. :::.:||::::|..|:|::::....||.|...:
Mouse   647 IVGMPGTGKT----TTICALVRILSACGFS-VLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKV 706

  Fly   533 DPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYANFDGSEESYQDTLAAQEKLN 597
            .|.|.||.     :.|:...|.     :.:..:.|:..|...:.|
Mouse   707 HPDIQKFT-----EEEICRSRS-----IASLAHLEELYNSHPIVA-------------------- 741

  Fly   598 QVAERIETLRMVFQFFLAREKDLLAMTTTC-AARHNFLFRLLQSKCVLFEEAAEIQEAHIVACLT 661
                                       ||| ...|....|.....|:: :||::|.:.   .||.
Mouse   742 ---------------------------TTCMGINHPIFSRKTFDFCIV-DEASQISQP---VCLG 775

  Fly   662 P--HTEHVILVGDHKQLQPFSGSRKVPQI----SLFERLIVAGLPFSRLNLQYRMR--------- 711
            |  .:...:|||||:||.|...:|:...:    |||:||........:|.:||||.
Mouse   776 PLFFSRRFVLVGDHQQLPPLVVNREARALGMSESLFKRLERNESAVVQLTVQYRMNRKIMSLSNK 840

  Fly   712 -------SCISE------LLVPSIYDELLCSESVKEYEDIRLMS------KNLYFVQHNQ---PE 754
                   .|.|:      |.:|::.|..|..:...:|.|...::      ..:.|:..::   ||
Mouse   841 LTYAGKLECGSDRVANAVLALPNLKDARLSLQLYADYSDSPWLAGVLEPDNPVCFLNTDKVPAPE 905

  Fly   755 HCMSDMSIGNLYEAGVLAKLTEFLIQKAQYKHSDIVILSPYNGQIECIKNALPQNYRSTVQVASV 819
            . :.:..:.|:.||.::..||...| ||....|||.:::||..|:..|.:.|.::....|:|.:|
Mouse   906 Q-VENGGVSNVTEARLIVFLTSTFI-KAGCSPSDIGVIAPYRQQLRIISDLLARSSVGMVEVNTV 968

  Fly   820 DSFQGLEANIVLLSLVRSNISGRIG-FLRQANRVCVALSRARWALYIVGNVTILKDTFPKI 879
            |.:||.:.:::|:|.||||..|.:| .|:...|:.|||:||:..|.::|:|:.|| .||.:
Mouse   969 DKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVALTRAKHKLILLGSVSSLK-RFPPL 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	53/243 (22%)
		AAA_19	467..>513	CDD:289986	14/45 (31%)
		UvrD_C_2	688..869	CDD:304668	60/216 (28%)
Dna2	NP_796346.2	Dna2	72..283	CDD:285859	23/124 (19%)
		Nuclease activity. /evidence=ECO:0000250	82..520		65/374 (17%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<256..398	CDD:294426	24/148 (16%)
		TIGR00376	472..1034	CDD:273041	153/644 (24%)
		Helicase activity. /evidence=ECO:0000250	521..1062		146/595 (25%)
		P-loop_NTPase	626..830	CDD:304359	63/269 (23%)
		AAA_12	806..1020	CDD:289832	60/215 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810