DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Upf1

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	195/757 - (25%)
Similarity:	318/757 - (42%)	Gaps:	187/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 KAPNEEEDEGLVSDKVVK--YVNALRNLLREDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVHL 291
            |.|:|   :|.:..:.:.  .:|.|..|.:|:..|..             .:|::.|:.....|:
  Fly   221 KQPSE---QGQLRARQISAAQINKLEELWKENIEATF-------------QDLEKPGIDSEPAHV 269

  Fly   292 TLNPQFANAQRHS-----LVFLKVQF---TKES---KNAYKTWLNSIKSGTLLCLTTS------- 338
            .|  ::.:..::.     ||.|:.::   .|||   :|....|...:...|:...|.:
  Fly   270 LL--RYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMK 332

  Fly   339 -LAFDDLILASVG-----YTE-------PEKLKEDCLSVQIVKQYNIGNAYNRPLIMFQAPVFFE 390
             :..|:|.|..||     ::|       |:...:| :.:::....|             |||...
  Fly   333 LMHGDELRLHYVGELYNPWSEIGHVIKVPDNFGDD-VGLELKSSTN-------------APVKCT 383

  Fly   391 PYLRVHNYLSTCSTE--------KFPMGRYIV--------------DGQMEI----PPPAYMKPG 429
            ....| :::..|::.        ||.:.|..|              |...|:    |.|
  Fly   384 SNFTV-DFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQP------ 441

  Fly   430 VKLSFNMKPFTLDKLPEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTHLSVQLVNSLIQNAKA 494
                   |.|:...||:   ||.||..|.|.||.|..|:||||||||||..|..:|..|::
  Fly   442 -------KLFSAPHLPD---LNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVK---- 492

  Fly   495 LGTGPIIVLTYTNNSLDKFLVKISRYTQEILRFGNQSR---DPQISKFNLSTTIKPELVPPRLKR 556
            |..|.::|...:|.::|:...||.|...:::|...:||   |..:|...|...|:.......||:
  Fly   493 LHGGTVLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKK 557

  Fly   557 IWWLVNCEYKEKFRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLL 621
            :         ::.::..|..::.|  |:.|::...|.|  ||:.|..:.:
  Fly   558 L---------QQLKDETGELSSAD--EKRYRNLKRAAE--NQLLEAADVI--------------- 594

  Fly   622 AMTTTCAARHNFLFRLLQSKCVLFEEAAEIQEAHIVACLTP---HTEHVILVGDHKQLQPFSGSR 683
              ..||....:.....::...:|.:|:.:..|..   |:.|   ..:.:||||||.||.|....:
  Fly   595 --CCTCVGAGDGRLSRVKFTSILIDESMQSTEPE---CMVPVVLGAKQLILVGDHCQLGPVVMCK 654

  Fly   684 KVPQI----SLFERLIVAGL-PFSRLNLQYRMRSCISELLVPSIYDELL----CSESVKEYEDIR 739
            |..:.    ||||||:|.|: || ||.:||||...:|:......|:..|    |:      ||.|
  Fly   655 KAARAGLSQSLFERLVVLGIRPF-RLEVQYRMHPELSQFPSNFFYEGSLQNGVCA------EDRR 712

  Fly   740 LM--------SKNLYF-VQHNQPEHCMSDMSIGNLYEAGVLAKL-TEFLIQKAQYKHSDIVILSP 794
            |.        .:.::| |...|.|...|..|..|..||..:.|: |.||  ||..|...|.|::|
  Fly   713 LKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFL--KAGIKPEQIGIITP 775

  Fly   795 YNGQIECI------KNALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSNISGRIGFLRQANRVC 853
            |.||...:      :.:|.......:::||||:|||.|.:|:::|.||||....||||....|:.
  Fly   776 YEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLN 840

  Fly   854 VALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNAIGE 895
            |||:||::.:.||||..:|..  .::||.::...|:...:.|
  Fly   841 VALTRAKFGIIIVGNPKVLAK--QQLWNHLLNFYKDRKVLVE 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	64/235 (27%)
		AAA_19	467..>513	CDD:289986	19/45 (42%)
		UvrD_C_2	688..869	CDD:304668	74/205 (36%)
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	7/30 (23%)
		DNA2	122..897	CDD:224037	195/757 (26%)
		Mis12	210..299	CDD:283509	16/95 (17%)
		AAA_19	458..>515	CDD:289986	24/60 (40%)
		AAA_12	661..857	CDD:289832	75/204 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840