DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_006233356.1	Gene:	Zgrf1 / 310880	RGDID:	1305834	Length:	2031	Species:	Rattus norvegicus

Alignment Length:	1027	Identity:	230/1027 - (22%)
Similarity:	396/1027 - (38%)	Gaps:	255/1027 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSSDDDWFDQDE---------NKLLQGLEKSLKSLELQKNEEYIECPPSERKCPPSEV----GEY 53
            ||:...|.....         |::...:.:.| |.|......:.....||....|..:    |..
  Rat  1075 SSTQSKWLKYQNPSHCNSAALNRIASEVTEDL-SAEAVSGLHFSHTSESESSVDPVHLQMIKGML 1138

  Fly    54 VMQHTRFSLTELTNALKMPAIDMFLYFLSDKRDLFENQVLATDNVK-RVGLFVDVLWSLCEL--- 114
            ..|...|:..:|.:..|..::::             ||...|..:: .:|....   |.|.:
  Rat  1139 YQQQQDFTSQDLVSRQKALSLNL-------------NQTSRTGELRTALGSSAS---SNCRVRDG 1187

  Fly   115 -ELGGFDEVF------LSAFSRQTALLDKIKNLLQAKAAVAKCDAESALILSHSKWMLLRAHKHG 172
             |:...|..|      |||:..|..:  .|..:.|:.|...:....|  |:.|...:|.     |
  Rat  1188 QEINNSDLCFPNGQKILSAYLPQRQV--HIPAVFQSPAHYRQIFTSS--IIEHLNILLF-----G 1243

  Fly   173 LLSHQGYELVELYKKLA-------PSFKSDMIDGLEAFTGNFSHNV-------------KGLIYP 217
            |..       .|||.|:       .|.|.:|:...:..:.:..||.             ||.::.
  Rat  1244 LAQ-------RLYKALSKVDISFYTSSKGEMMKSGKNNSPSCHHNQPAKLVMVKKEGPNKGRLFY 1301

  Fly   218 TLETLLG---------KDATK---APNEEEDEGLVSDKVVKYVNALRNLLREDFLAPLVEFVQQL 270
            |.:...|         :|.|.   :.||.:...:.:|     :.::.:.||...:|...|....|
  Rat  1302 TCDKPKGNQCKFFKWLEDVTPEQLSQNESQPNMIFND-----IKSIGSYLRSQKIAVYEECQLLL 1361

  Fly   271 RSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHSLVFLKVQFTKESKNAYKTWLNSIKSGTLLCL 335
            |.|.|..: ||.|.|  ....|:||:| .::..|.::||:. .|||.:.|       ..|.|..:
  Rat  1362 RKGFDFQK-KQHGKL--KKLATVNPEF-YSETKSKLYLKLS-RKESSSVY-------SKGDLWVI 1414

  Fly   336 TTSLAFD-DLILASVGYTEPEKLKE------------------------DC-LSVQIVKQYNIGN 374
            :.:|.|: |..:|...:..|..:.|                        .| :|.::....||.:
  Rat  1415 SKTLDFELDTFIACSAFFGPSSVNEVELLPLKGYFPSNWPTNITVHALLVCNVSTELTMLQNIQD 1479

  Fly   375 AYN---RPLIMFQAPVFFEPYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSFNM 436
            .:|   .||:         |||...:..:|.|::.....::|        |||.  ..:|..|.:
  Rat  1480 YFNPATLPLM---------PYLLAMSQSATVSSKNVSKRKFI--------PPAI--TSIKTKFEL 1525

  Fly   437 KPF--TLDKLPE--DLH-LNESQKTAF-------------KEALCREFS------IIQGPPGTGK 477
            ...  ||....|  ::| ||..|.:|.             ::|| ..||      :|.|..|.||
  Rat  1526 LHLGATLQLARELINVHRLNNDQASALMQIAQMMASRGSDEDAL-EPFSHSLPITVIHGVFGAGK 1589

  Fly   478 THLSVQLVNSLIQ-----NAKALGTG---PIIVLTYTNNSLDKFLV-KISRYTQEILRFGNQSRD 533
            ::|...::..|::     :::|:|..   .:::.:.||.::|:.|: .:|...::.:|.|:..:
  Rat  1590 SYLLAVVILFLVELFEKCDSEAVGRARPWKLLISSSTNVAVDRVLLGLLSLGFEKFIRVGSVRK- 1653

  Fly   534 PQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYANFDGSEESYQDTLA-AQEKLN 597
                       |...::|                     ..|:|:.|...|..::..| .:|:|.
  Rat  1654 -----------IAKPVLP---------------------YSLHASSDNESEQLKELHALMREELT 1686

  Fly   598 QVAERIETLRMVFQFFLAREKDLL----AMTTTCAARHNFLFRLLQSKCVLFEEAAEIQEAHIVA 658
            .: ||:...:.:.|..|...:.||    .:..||||........|:...|:.:|.:::.|.   |
  Rat  1687 PI-ERVYVRKSIEQHKLGTNRVLLKQARVVGITCAACPFPCMNDLKFPVVVLDECSQMTEP---A 1747

  Fly   659 CLTP----HTEHVILVGDHKQLQP-FSGSRKVP----QISLFERLIVAGLPFSRLNLQYRMRSCI 714
            .|.|    ..|.:|||||.|||.| ..||....    :.:||:||.:.|....:|..|||....|
  Rat  1748 SLLPIARFECEKLILVGDPKQLPPTIQGSDAAHGNGLEQTLFDRLCLMGHKPIQLRTQYRCHPVI 1812

  Fly   715 SELLVPSIYD-ELLCSESVKEYEDIRLMSKNLYFVQHNQPEHCMSDMSIGNLYEAGVLAKLTEFL 778
            |.:.....|: .|:...|.:|...:......|.|......|....:.|..|:.||....||...|
  Rat  1813 SAIANDLFYEGNLVNGISERERSPVLEWLPTLCFYNVTGTEQVERENSFVNVAEAAFTLKLIRSL 1877

  Fly   779 IQKAQYKHSDIVILSPYNGQIECIKNAL-------PQNYRSTVQVASVDSFQGLEANIVLLSLVR 836
            |... .:.|.|.:::.|..|:..|.:.|       |.  ...|:|::||:|||.|..|::||.||
  Rat  1878 IASG-LEGSMIGVITLYKSQMYKICSLLSAVDVDHPD--VKAVEVSTVDAFQGAEKEIIILSCVR 1939

  Fly   837 SNISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLK 888
            :.   ::||:....|:.|||:|.|..|.|:|:::.|:..  ::|..:::..|
  Rat  1940 TR---QVGFIDSEKRMNVALTRGRRHLLIIGSLSCLRKN--QLWGRVIQHCK 1986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	61/268 (23%)
		AAA_19	467..>513	CDD:289986	13/59 (22%)
		UvrD_C_2	688..869	CDD:304668	57/188 (30%)
Zgrf1	XP_006233356.1	DUF2439	3..75	CDD:402138
		zf-GRF	1276..1320	CDD:399670	6/43 (14%)
		DEAD-like_helicase_N	1543..1807	CDD:421690	69/301 (23%)
		AAA_12	1784..1968	CDD:404073	56/189 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900