DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Mov10

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_001101181.1	Gene:	Mov10 / 310756	RGDID:	1598327	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	779	Identity:	173/779 - (22%)
Similarity:	276/779 - (35%)	Gaps:	213/779 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GLIYP------TLETLL-GKDATKAPNEEEDEGLVSDKVVK---YVNALRNLLREDFLAPLVEFV 267
            |..||      .|.||| |.....:|.|..:.....:..:|   |...||.||.          :
  Rat   293 GTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIKAQLETTLKSRNYEVKLRLLLH----------L 347

  Fly   268 QQLRSGTDVD--ELKQQGLLWSDVH-----LTLNPQFANAQR-------HSLVFLKVQFTKESKN 318
            ::|:...|:.  :|:...:.|..|.     |||........|       |....|..:..:|...
  Rat   348 EELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSEIQQEDPV 412

  Fly   319 AYKTWLNSIKSGTLLCLTTSLAFDDLILASV--GYTEPEKLKEDCLSVQIVKQYNIGNAYNRPLI 381
            .||.:::.::...:     .|:|...:|:..  |.|                 :.:...:||
  Rat   413 TYKGFVHKVELDRV-----KLSFSPSLLSRFVDGLT-----------------FKVNFTFNR--- 452

  Fly   382 MFQAPVFFEPYLRV-HNYLSTCSTEKFPMGRYIVDGQMEIPPPAY--MKPGVKL-----SFNMKP 438
                    :| ||| |..|..       .||::      :.|..:  ...||.|     .|.:..
  Rat   453 --------QP-LRVQHRALEL-------TGRWV------LWPTLFPVASRGVSLLPSDVKFKLYD 495

  Fly   439 FTLDKLPEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTHLSVQLVNSLIQNAKALGTGPIIVL 503
            .:|:..||.|   ::.|...:........||.||||||||   |.||.::.|..|.|....|:..
  Rat   496 RSLESNPEQL---QAMKHIVRGTTRPAPYIIFGPPGTGKT---VTLVEAIKQVVKHLPKAHILAC 554

  Fly   504 TYTNNSLDKFLVKIS-RYTQEILRFGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKE 567
            |.:|:..|....::. .....|.|....|||.:             :||..:|      .|
  Rat   555 TPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIR-------------MVPEDIK------TC---- 596

  Fly   568 KFRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLLAMTTTCAARHN 632
                     .|:|..:..|  ...|::.|.|....|.||....:...|:
  Rat   597 ---------CNWDPKKGEY--VYPAKKHLQQYRVLITTLITASRLVSAQ---------------- 634

  Fly   633 FLFRLLQSKCVLFEEAAEIQEAHIVACLTPHTE---------HVILVGDHKQLQPFSGSRKVPQ- 687
              |.:.....:..:||....|...:..:....:         .::|.||.:||.|...|....:
  Rat   635 --FPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKH 697

  Fly   688 ---ISLFERLIVAGLPF------------SRLNLQYRMRSCISELLVPSIYDELL--CSESVKEY 735
               .||.|||:.....:            ::|...||....|.::.....||..|  |::.|...
  Rat   698 GLGYSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRE 762

  Fly   736 EDIR---LMSKNLYFVQH---NQPEHCMSDMSIGNLYEAGVLAKLTEFLIQ---------KAQYK 785
            ...|   |..:....:.|   .:.|...:..|..|..||   |.:|.:|.|         ||:..
  Rat   763 RFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEA---ATVTSYLRQLLAPSSKKGKARLS 824

  Fly   786 HSDIVILSPYNGQIECIKNALPQNYR--------STVQVASVDSFQGLEANIVLLSLVRS----- 837
            ...:.::|||..|:|.|:..:.:..|        ..::|.||:.|||.|.:::|:|.|||
  Rat   825 PRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFV 889

  Fly   838 --NISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNA-IGEAFP 898
              ::...:|||:...|..||::||:..|.:|||..:|... |. |...::..|||.. .|..||
  Rat   890 QLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHD-PD-WKTFLEFCKENGGYTGCPFP 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	49/239 (21%)
		AAA_19	467..>513	CDD:289986	20/45 (44%)
		UvrD_C_2	688..869	CDD:304668	58/224 (26%)
Mov10	NP_001101181.1	DEXXQc_Helz-like	499..734	CDD:350796	60/292 (21%)
Mov10	NP_001101181.1	SF1_C_Upf1	735..940	CDD:350195	54/209 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900