DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_113774.2	Gene:	Ighmbp2 / 29532	RGDID:	68325	Length:	988	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	184/755 - (24%)
Similarity:	291/755 - (38%)	Gaps:	236/755 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 EDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVHLTLNPQFANAQRHSLVFLKVQFTKESKNAYK 321
            |.|:|..::.: :|....:|:|.:.    |.: |.:|.    ..|...:..||:|.:.:....|.
  Rat     7 ESFVAQQLQLL-ELERDAEVEERRS----WQE-HSSLK----ELQSRGVCLLKLQVSGQRTGLYG 61

  Fly   322 TWL----------------NSIKSGTLLCL--------------------TTSLAFDD------- 343
            ..|                ||..||.::.|                    :..:|||:
  Rat    62 QRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYDTNESSQLATGVLTRITQKSVIVAFDESHDFQLN 126

  Fly   344 ---------LILAS-VGYTEPEKLKEDCLSVQIVKQYNIGNAYNRPLIMFQAPVFFEPYLRVHNY 398
                     |.||: |.|   ::||:..|:   :|:|:.|.|.:...::
  Rat   127 LDRENTYRLLKLANDVTY---KRLKKALLT---LKKYHSGPASSLIDVL---------------- 169

  Fly   399 LSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSFNMKPFTLDKLPEDLHLNESQKTAFKEALC 463
                      :|........||||..:        :|.   |||         .|||.|...||.
  Rat   170 ----------LGGSTPSPATEIPPLTF--------YNT---TLD---------PSQKEAVSFALA 204

  Fly   464 -REFSIIQGPPGTGKTHLSVQLV-NSLIQNAKALGTGPIIVLTYTNNSLDKFLVKISRYTQEILR 526
             :|.:||.||||||||...|::: .::.|..|.|...|      :|.::|..:.:::...::|||
  Rat   205 QKEVAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAP------SNIAVDNLVERLALCKKQILR 263

  Fly   527 FGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYANFD---GSEESYQD 588
            .|:.:|        |..:::...:...|.|         .:..:.:..:..:.|   |..:..||
  Rat   264 LGHPAR--------LLESVQQHSLDAVLAR---------SDNAQIVADIRRDIDQVFGKNKKTQD 311

  Fly   589 TLAAQEKLN----------QVAERIETLRMVFQFFLAREKDLLAMTTTCAARHNFLFRLLQS--- 640
               .:||.|          ::.||.|.  .:.|...|  .|::..|.|.|:....| :||..
  Rat   312 ---KREKSNFRNEIKLLRKELKEREEA--AIVQSLSA--ADVVLATNTGASTDGPL-KLLPEDYF 368

  Fly   641 KCVLFEEAAEIQEAHIVACLTP--HTEHVILVGDHKQLQPFSGSRKVP----QISLFERLIVA-G 698
            ..|:.:|.|:..||   :|..|  .....||.||||||.|.:.|.|..    ..||.|||... |
  Rat   369 DVVVVDECAQALEA---SCWIPLLKAPKCILAGDHKQLPPTTVSHKAALAGLSRSLMERLAEKHG 430

  Fly   699 LPFSR-LNLQYRMRSCI----SELLV-------PSIYDELL-----------------------C 728
            ....| |.:||||...|    ||.:.       ||:...||                       |
  Rat   431 AAVVRMLAVQYRMHQAITRWASEAMYHGQLTAHPSVAGHLLKDLPGVADTEETSVPLLLIDTAGC 495

  Fly   729 SESVKEYEDIRLMSKNLYFVQHNQPEHCMSDMSIGNLYEAGVLAKLTEFLIQKAQYKHSDIVILS 793
            .....|.||.:  ||.      |..|..:..:.|..|.:|||.|              .||.:::
  Rat   496 GLLELEEEDSQ--SKG------NPGEVRLVTLHIQALVDAGVQA--------------GDIAVIA 538

  Fly   794 PYNGQIECIKNALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSNISGRIGFLRQANRVCVALSR 858
            |||.|::.::.:| .|....:::.|||.|||.|...|:|:.||||..|.:|||.:..|:.||::|
  Rat   539 PYNLQVDLLRQSL-SNKHPELEIKSVDGFQGREKEAVILTFVRSNRKGEVGFLAEDRRINVAVTR 602

  Fly   859 ARWALYIV-GNVTILKDTFPKIWNPIVKRLKENNAIGEAF 897
            ||..:.:: .:.|:....|.|   .:|....|:..:..||
  Rat   603 ARRHVAVICDSHTVNNHAFLK---TLVDYFTEHGEVRTAF 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	66/249 (27%)
		AAA_19	467..>513	CDD:289986	17/46 (37%)
		UvrD_C_2	688..869	CDD:304668	64/217 (29%)
Ighmbp2	NP_113774.2	TIGR00376	19..640	CDD:273041	181/742 (24%)
		SS DNA-binding. /evidence=ECO:0000250	637..783		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722
		R3H_Smubp-2_like	724..782	CDD:100070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..872
		Nuclear localization signal. /evidence=ECO:0000255	857..861
		ZnF_AN1	890..930	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810