DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and Mov10

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_001156912.1	Gene:	Mov10 / 17454	MGIID:	97054	Length:	1077	Species:	Mus musculus

Alignment Length:	778	Identity:	177/778 - (22%)
Similarity:	279/778 - (35%)	Gaps:	211/778 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GLIYP------TLETLL-GKDATKAPNEEEDEGLVSDKVVK---YVNALRNLLREDFLAPLVEFV 267
            |..||      .|.||| |.....||.|..:.....:..:|   |...||.||.          :
Mouse   366 GTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKAQLETTLKSRNYEVKLRLLLH----------L 420

  Fly   268 QQLRSGTDVD--ELKQQGLLWSDVH-----LTLN-PQFANAQ------RHSLVFLKVQFTKESKN 318
            ::|:...|:.  :|....:.|..|.     |||. |..|.::      .|....|..:..::...
Mouse   421 EELQMEHDIRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPV 485

  Fly   319 AYKTWLNSIKSGTL-LCLTTSL--AFDDLILASVGYTEPEKLKEDCLSVQIVKQYNIGNAYNRPL 380
            .||.:::.::...: |..:|||  .|.|.:...|.:|                       :||
Mouse   486 TYKGFVHKVELDRVKLSFSTSLLSRFVDGLTFKVNFT-----------------------FNR-- 525

  Fly   381 IMFQAPVFFEPYLRV-HNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKL-----SFNMKPF 439
                     :| ||| |..|..       .||::: ..|..|   ....||.|     .|.:...
Mouse   526 ---------QP-LRVQHRALEL-------TGRWVL-WPMLFP---VASRGVSLLPSDVKFKLYDR 569

  Fly   440 TLDKLPEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTHLSVQLVNSLIQNAKALGTGPIIVLT 504
            :|:..||.|   ::.|...:........||.||||||||   |.||.::.|..|.|....|:...
Mouse   570 SLESNPEQL---QAMKHIVRGTTRPAPYIIFGPPGTGKT---VTLVEAIKQVVKHLPKAHILACA 628

  Fly   505 YTNNSLDKFLVKIS-RYTQEILRFGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEK 568
            .:|:..|....::. .....|.|....|||.:             :||..:|      .|
Mouse   629 PSNSGADLLCQRLRVHLPSSIYRLLAPSRDIR-------------MVPEDIK------TC----- 669

  Fly   569 FRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLLAMTTTCAARHNF 633
                    .|:|..:..|  ...|::.|.|....|.||....:...|:
Mouse   670 --------CNWDAKKGEY--VYPAKKHLQQYRVLITTLITASRLVSAQ----------------- 707

  Fly   634 LFRLLQSKCVLFEEAAEIQEAHIVACLTPHTE---------HVILVGDHKQLQPFSGSRKVPQ-- 687
             |.:.....:..:||....|...:..:....:         .::|.||.:||.|...|....:
Mouse   708 -FPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHG 771

  Fly   688 --ISLFERLIVAGLPF------------SRLNLQYRMRSCISELLVPSIYDELL--CSESVKEYE 736
              .||.|||:.....:            ::|...||....|.::.....||..|  |::.|....
Mouse   772 LGYSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRER 836

  Fly   737 DIR---LMSKNLYFVQH---NQPEHCMSDMSIGNLYEAGVLAKLTEFLIQ---------KAQYKH 786
            ..|   |..:....:.|   .:.|...:..|..|..||   |.:|.:|.|         ||:...
Mouse   837 FCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEA---ATVTSYLKQLLAPSSKKGKARLSP 898

  Fly   787 SDIVILSPYNGQIECIKNALPQNYR--------STVQVASVDSFQGLEANIVLLSLVRS------ 837
            .::.::|||..|:|.|:..:.:..|        ..::|.||:.|||.|.:::|:|.|||
Mouse   899 RNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQ 963

  Fly   838 -NISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNA-IGEAFP 898
             ::...:|||:...|..||::||:..|.:|||..:|... |. |...::..|||.. .|..||
Mouse   964 LDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHD-PD-WKTFLEFCKENGGYTGCPFP 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	48/239 (20%)
		AAA_19	467..>513	CDD:289986	19/45 (42%)
		UvrD_C_2	688..869	CDD:304668	58/224 (26%)
Mov10	NP_001156912.1	AAA_11	574..765	CDD:289831	52/248 (21%)
		P-loop_NTPase	574..>761	CDD:304359	51/244 (21%)
		AAA_12	772..996	CDD:289832	58/226 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900