DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and smg-2

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	NP_490829.1	Gene:	smg-2 / 171696	WormBaseID:	WBGene00004880	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	681	Identity:	176/681 - (25%)
Similarity:	297/681 - (43%)	Gaps:	116/681 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 VDELKQQGLLWSDVHLTLNPQFANAQRHSLVF-----LKVQFTKESKNAYK------TWLNSIKS 329
            ||:|.:.||.....|:.|  ::.:|..:|.||     ::.::.:..|.:..      .|...::.
Worm   249 VDDLNKPGLDREPDHVQL--RYVDAHHYSKVFRPLVAIEAEYDRRVKESASQAVGTVRWEQGLRQ 311

  Fly   330 GTLLCLTTSLAFDDLILASVGYTEPEKLKEDCLSVQIVKQYNIGNAYNRP--------------- 379
            ..|.........|.::..:.|  :..:||.. .:|...:...||:.:..|
Worm   312 SVLAFFHLPQFADGVMKLAKG--DELRLKHS-QTVDGSEWTKIGSVFKIPDNHGDEVGIEIRGAV 373

  Fly   380 -------LIMFQAPVFFE--PYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPPAYMKPGVKLSFN 435
                   .|||...|.:.  .:.|.:..|:....:...:..|:....:..|....|     |.|:
Worm   374 DKSVMESRIMFTVDVVWNATTFERQYKALAALLNDSKAISPYLYQKLLGHPAEEMM-----LKFD 433

  Fly   436 M-KPFTLDKLPEDLHLNESQKTAFKEALCREFSIIQGPPGTGKTHLSVQLVNSLIQNAKALGTGP 499
            : :..::..|||   ||.||..|.|:.|.|..|:||||||||||.:|..:|..|:|..:    |.
Worm   434 LPRRLSVAGLPE---LNSSQMQAVKQVLTRPLSLIQGPPGTGKTVVSATIVYHLVQKTE----GN 491

  Fly   500 IIVLTYTNNSLDKFLVKISRYTQEILRFGNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCE 564
            ::|.:.:|.::|....||.:...:::|...:||:      :..||:....:..:||    ::...
Worm   492 VLVCSPSNIAVDHLAEKIHKTGLKVVRLCARSRE------HSETTVPYLTLQHQLK----VMGGA 546

  Fly   565 YKEKFRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLLA----MTT 625
            ..:|...|:.     :..|..::|.|           |...|:.|      :|.:|||    :..
Worm   547 ELQKLIQLKD-----EAGELEFKDDL-----------RYMQLKRV------KEHELLAAADVICC 589

  Fly   626 TCAARHNFLFRLLQSKCVLFEEAAEIQEAHIVACLTPHTEHVILVGDHKQLQPFSGSRKVP---- 686
            ||::..:.....::::.||.:|:.:..|..|:..:......::|||||.||.|....:|..
Worm   590 TCSSAADARLSKIRTRTVLIDESTQATEPEILVSIMRGVRQLVLVGDHCQLGPVVICKKAAIAGL 654

  Fly   687 QISLFERLIVAGL-PFSRLNLQYRMRSCISELLVPSIYDELLCSESVKEYEDIRLMSKNLYFVQH 750
            ..||||||::.|: || ||.:||||...:||......||..| ...|.| .|..:...:.::.:.
Worm   655 SQSLFERLVLLGIRPF-RLQVQYRMHPVLSEFPSNVFYDGSL-QNGVTE-NDRHMTGVDWHWPKP 716

  Fly   751 NQPE---HC-------MSDMSIGNLYEAGVLAKLTEFLIQKAQYKHSDIVILSPYNGQIECIKN- 804
            |:|.   ||       .|..|..|..||..:.||...|| ||..:...|.:::||.||...|.|
Worm   717 NKPAFFWHCSGSEELSASGTSFLNRTEAANVEKLVSKLI-KAGVQPHQIGVITPYEGQRSFIVNY 780

  Fly   805 -----ALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSNISGRIGFLRQANRVCVALSRARWALY 864
                 .|.......|::||||:|||.|.:.::::.||||....||||....|:.||::||::.|.
Worm   781 MHTQGTLNSKLYENVEIASVDAFQGREKDYIIVTCVRSNDILGIGFLSDPRRLNVAITRAKYGLV 845

  Fly   865 IVGNVTILKDTFPKIWNPIVKRLKENNAIGE 895
            :|||..:|  ....:|:.::...|....:.|
Worm   846 LVGNAKVL--ARHDLWHELINHYKSKEMLYE 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	62/233 (27%)
		AAA_19	467..>513	CDD:289986	19/45 (42%)
		UvrD_C_2	688..869	CDD:304668	71/197 (36%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:286500
		DNA2	117..874	CDD:224037	175/679 (26%)
		AAA_19	452..>509	CDD:289986	23/60 (38%)
		AAA_12	654..851	CDD:289832	72/200 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810