DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and zgrf1

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_031758647.1	Gene:	zgrf1 / 100327248	XenbaseID:	XB-GENE-6461443	Length:	1948	Species:	Xenopus tropicalis

Alignment Length:	1048	Identity:	230/1048 - (21%)
Similarity:	376/1048 - (35%)	Gaps:	297/1048 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EYIECPPSERKCPPSEVGEY-------VMQHTRF--SLTELTNALKMPAIDMFLYFLSDKRDLFE 89
            ||.:| ..:..|.||. ..|       |..|..|  ::.|.|..|| |..|........|...::
Frog   947 EYKKC-FLDTNCSPSP-NIYTTKNLIDVPVHNAFVENIEEGTGFLK-PTEDRNSPKRQSKWTKYQ 1008

  Fly    90 NQVLAT---DNVKRVGLFVDVLWSLCELELGGFDEVFL-SAFSRQTALLDKIKNLLQAKAAVAKC 150
            |:.|.:   :||:               ::...:|.|. |.|.::..:.||:.:    ||:|
Frog  1009 NKSLCSRTNENVE---------------DMKANEEFFAKSLFGKEPYMADKVDD----KASV--- 1051

  Fly   151 DAESALILSHSKWMLLRAHKHGLLSHQGYELVELYKKLAPSFK-SDMIDGLEAFTGNFSHNVK-- 212
               .::.|:..|..|.:.:. ||:.|      .|:.|..|:.. :.:..|..:|..:.|.|||
Frog  1052 ---ESICLTLLKDTLSKKNS-GLVQH------GLHTKRHPTISIAQLNKGKTSFLSDSSGNVKIS 1106

  Fly   213 -GLIYPTLETLLGKDATKAPNEEEDEGLVSDKVVKYVNALRNLLREDFLAPLVEFVQQL-RSGTD 275
             .|.:|:.||:  :.....|..|....::...|..|.:.....|.|.....:.|..|:| ::.:.
Frog  1107 CELHFPSRETV--QSTVSIPKREISIPILYQSVTHYKHVFTAALTEHLNIMMFELSQRLYKALSK 1169

  Fly   276 VD-----ELKQQGLLWSDVHLTLNPQFANAQRHSLVFLKVQ--------FT----KESKNAYKTW 323
            ||     ..:..|.:...   .:.|...:.|...||.:|.:        :|    |..:..:..|
Frog  1170 VDMSFYTSSRAAGEMGKH---NVTPLCLHQQPAKLVMVKKEGPNKGRFFYTCDAPKSDQCKFFKW 1231

  Fly   324 LN-------------------SIKSGTLLCLTTSLA----------------------FDDLILA 347
            ||                   .:||......:..:|                      |..:|.|
Frog  1232 LNETQCSSPVQGHAQPKVVMGDMKSVASFVRSHKVALYEESHLMVRKVSGFQNKSFGKFKKIINA 1296

  Fly   348 SVGYTEPEKLKEDCLSVQIVKQYNIGNAYNR-------------PLIMFQA-PVFFEPYLR---- 394
            :..:....|.|   |.:::.::.| .:||::             |:..|.| .|||.|...
Frog  1297 NSDFAGESKTK---LYLKLNRKEN-SSAYSKDDLWVVSKTIDFEPVDTFVAFSVFFGPSANNEIE 1357

  Fly   395 -----------------VHNYL-STCSTE--------------KFPMGRYIVDGQME-------- 419
                             ||..| ...|||              ..|:..:::..|.|
Frog  1358 IQPLKGYSPSNWPSNTLVHAVLVCNASTELTSLRNIQEHLNPSTLPIMPHLLKMQSEQEGESKTN 1422

  Fly   420 ----IPPPAYMKPGVKLSFNMKPFTLDK---LPEDLHLNESQKTAFKE-------------ALCR 464
                .||....|...:.......|.|.|   :.|...|||.|.||..:             |:..
Frog  1423 TGKFKPPSLTAKIPQRCELPSCSFILAKSQEMIEQFRLNEDQATALMQIAQMMTTAAGSYKAVAP 1487

  Fly   465 EFSIIQGPPGTGKTHLSVQLVNSLIQ------NAKALGTGP--IIVLTYTNNSLDKFLV------ 515
            ..::|.|..|.||::|...:|..|:|      .|:.....|  |::.:.||.::|:.|:
Frog  1488 PITVIHGVFGAGKSYLLSVVVLFLVQLFERGNPAEGYEASPWKILISSSTNVAVDRVLLGLLDLG 1552

  Fly   516 --------KISRYTQEILRF----GNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEK 568
                    .|.:..:.||.|    |:::.:.||.:  |...:|.:|.|
Frog  1553 FSQFVRVGSIRKIAKPILPFSLHAGSENENEQIKE--LLALLKDDLTP----------------- 1598

  Fly   569 FRNLQGLYANFDGSEESYQDTLAAQEKLNQVAERIETLRMVFQFFLAREKDLLAMTTTCAARHNF 633
                         .|::|......|.||......:..:|:|              ..||||....
Frog  1599 -------------VEKAYVRKSIEQHKLGTNKALLGQVRVV--------------GATCAACPFA 1636

  Fly   634 LFRLLQSKCVLFEEAAEIQEAHIVACLTP----HTEHVILVGDHKQLQP-FSGS----RKVPQIS 689
            ....|:...|:.:|.:::.|.   |.:.|    ..|.:|||||.|||.| ..||    .|..:.:
Frog  1637 CMSNLKFPVVVLDECSQMTEP---ASMLPVARFQCEKLILVGDPKQLSPTIQGSEPAHEKGLEQT 1698

  Fly   690 LFERLIVAGLPFSRLNLQYRMRSCISELLVPSIYDELLCSESVKEYEDIRLMS--KNLYFVQHNQ 752
            ||.||.:.|.....|..|||....|..:.....||..|.: .|.|.:...|:.  ..|.|...|.
Frog  1699 LFSRLCLMGHKAIILRTQYRCHPAICSIANELFYDSHLIN-GVSEEDRKPLLDWLPTLCFYNVNG 1762

  Fly   753 PEHCMSDMSIGNLYEAGVLAKLTEFLIQKAQYKHSDIVILSPYNGQIECIKNALPQNYR------ 811
            .|....:.|..|:.||....||.:.||... .:.|.|.:::.|..|:..|.:.|..:..
Frog  1763 TEQVEGNNSFYNMEEANFTVKLIQSLIASG-IEGSMIGVITLYKSQMYKIFSLLASSAHCDSTDI 1826

  Fly   812 STVQVASVDSFQGLEANIVLLSLVRSNISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTF 876
            ..|||::||:|||.|..|::||.||:.   ::||:....|:.|.|:|.:..|.|:.|:..|:..
Frog  1827 KAVQVSTVDAFQGAEKEIIILSCVRTR---QVGFIDSEKRMNVGLTRGKRHLLIIANLACLRKN- 1887

  Fly   877 PKIWNPIV 884
             |:|..::
Frog  1888 -KLWEHVI 1894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	61/273 (22%)
		AAA_19	467..>513	CDD:289986	15/53 (28%)
		UvrD_C_2	688..869	CDD:304668	56/188 (30%)
zgrf1	XP_031758647.1	DUF2439	6..71	CDD:402138
		zf-GRF	1191..1234	CDD:399670	9/42 (21%)
		DEAD-like_helicase_N	1460..1718	CDD:421690	71/306 (23%)
		AAA_12	1695..1880	CDD:404073	56/189 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910