DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6204 and setx

DIOPT Version :9

Sequence 1:	NP_651229.2	Gene:	CG6204 / 42877	FlyBaseID:	FBgn0039165	Length:	903	Species:	Drosophila melanogaster
Sequence 2:	XP_002936221.1	Gene:	setx / 100145435	XenbaseID:	XB-GENE-966858	Length:	2535	Species:	Xenopus tropicalis

Alignment Length:	966	Identity:	189/966 - (19%)
Similarity:	333/966 - (34%)	Gaps:	316/966 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 EVFLSAFSRQTALLDK-IKN------LLQAKAAVAKC----------------DAESAL--ILSH 160
            :||.|:.:.:||.|.| ::|      :|:||...||.                |..|.|  :::.
Frog  1504 KVFASSNTSRTASLTKDLENFPRPQGILKAKPQSAKAPVPKLPKPLTVQNRASDTNSVLQPLINQ 1568

  Fly   161 SKWMLLRAHKHGLLSHQGYELVELYKKLAPSFKSDMIDGLEAFTGNFSHNVKGLIYPTLETLLGK 225
            |          .:.|...|..|....||.|.
Frog  1569 S----------NVPSKPSYSAVSEAGKLRPY---------------------------------- 1589

  Fly   226 DATKAPNEEEDEGLVSDKVVKYVNALRNLLREDFLAPLVEFVQQLRSGTDVDELKQQGLLWSDVH 290
             |.:.|.::.|:|.:          :|.||:..|     |....:........|.|..||...:
Frog  1590 -AAQKPLQQRDQGWL----------MRELLQWKF-----EMFDNVSRFGPPSNLCQLPLLKVPI- 1637

  Fly   291 LTLNPQFANAQRHSLVFLKVQFTKESKNAYKTWLNSIKSGTL----------------------- 332
                 :|::.:.:..||..:......::..:.|  |:|...:
Frog  1638 -----KFSSYEEYFNVFFPLMLLNTFESLAQEW--SVKQKAIHTDLCKLHLQNFCPDGLVNRGEF 1695

  Fly   333 --------LCLTTSLAFDDLILASVGYTEPEKLKEDCLS---------------------VQIVK 368
                    ||:......|||:...:..:.|....|:.:|                     .|..:
Frog  1696 QVWFRDADLCMQRHPKEDDLVFLCMPESTPSLSGEEMVSHGARVYHTGYVSRFNRSHRTQSQEKE 1760

  Fly   369 QYNI--------GN--AYNRPLIMFQAPVFFEPYLRVHNYLSTCSTEKFPMGRYIVDGQMEIPPP 423
            ||.:        ||  |:....:  :..|..........:.:....::.|:.|.|:     :|.|
Frog  1761 QYTLCDLCIHTQGNLSAFRNQQV--RCAVIGSLITTQRQFRALLQLQRNPLFRPII-----LPNP 1818

  Fly   424 AYMKPGVKLSFNMKPFTLDKLPEDLHLNESQKTAFKEA------------LCREFSIIQGPPGTG 476
            |...|....:.....|     |.....|..|:.|.::|            :|    :|.||||||
Frog  1819 ADFIPRDNAASESSSF-----PSLKEYNSDQRYAIEKAYSMVKQHPRLPRIC----LIHGPPGTG 1874

  Fly   477 KTHLSVQLVNSL----------IQNAKALG-TGPIIVLTYTNNSLDKFLVKISRYTQEILRF--- 527
            |:...|.|:..:          :||..|.. ...::|...:|.:||..:.||      ||.|
Frog  1875 KSKTIVGLLYRILMENGSSTVPVQNLSAKNKRNRVLVCAPSNAALDDLMKKI------ILEFKEK 1933

  Fly   528 --------GNQSRDPQISKFNLSTTIKPELVPPRLKRIWWLVNCEYKEKFRNLQGLYANFDGSEE 584
                    || ..|..:.:.....||..::|.       :.::|:...:....|       ..:|
Frog  1934 CHNKNTPLGN-CGDINLVRLGAEKTISSDVVK-------FSLDCQVNHRITRAQ-------QDQE 1983

  Fly   585 SYQDTLAAQEKLNQVAER---------------IETLRMVFQFFLAREKDLLA------------ 622
            .::.......:|::::.|               .|..|      |::|:.|||
Frog  1984 LHKRKELLDRRLDELSRRRALEKCNKNTCAPLDEEIAR------LSKERQLLADSLKLVRRRPQE 2042

  Fly   623 ---------------MTTTCAARHNFLFRLLQSK---CVLFEEAAEIQEAHIVACLTPHTEHVIL 669
                           ::|:........||.|..:   ||:.:||.:..|...:..|......::|
Frog  2043 LQRTIILESHVICCTLSTSGGILLESAFRQLGQEPFSCVIVDEAGQSCEVENLIPLLHRCSKLVL 2107

  Fly   670 VGDHKQLQPFSGSRKVPQI----SLFERLIV------AGLPFSRLNLQYRMRSCISELLVPSIYD 724
            |||.:||.|...|.|..::    ||..|:..      ...|...|.:||||...|  .|.||.|.
Frog  2108 VGDPEQLPPTVISMKAEELGYGQSLMSRMCSFLDSTGTKSPVLHLTVQYRMHPDI--CLFPSHYF 2170

  Fly   725 ELLCSESVKEYEDIRLMSKNLY-----------FVQHNQPEHCMSDMSIGNLYEAGVLAKLTEFL 778
            .....::.:..|::|..|...:           |.|..:...|       |..|..|...|.:.:
Frog  2171 YKRMLKTDRATEEVRCSSDWPFQPYMVFDVADGFEQKERESFC-------NPQEIKVAVALIKLI 2228

  Fly   779 -IQKAQYKHSDIVILSPYNGQ----IECIKNALPQNYRSTVQVASVDSFQGLEANIVLLSLVRSN 838
             .:|.::...:|.:::||..|    ||.::.|...:.|.. :|.:||.|||.:.:.::::.||:|
Frog  2229 KSRKKEFCFRNIGVITPYRAQKMRIIEELRRAFGNDIRPG-EVDTVDGFQGRQKDCIIVTCVRAN 2292

  Fly   839 -ISGRIGFLRQANRVCVALSRARWALYIVGNVTILKDTFPKIWNPIVKRLKENNAI 893
             ..|.||||....|:.|.::||:::|:|:|::..|.:.  |.||.:::..:...|:
Frog  2293 STQGGIGFLASRQRLNVTITRAKFSLFILGSLRTLMEN--KDWNHLIQDAQRRGAL 2346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6204	NP_651229.2	AAA_11	449..679	CDD:289831	61/308 (20%)
		AAA_19	467..>513	CDD:289986	17/56 (30%)
		UvrD_C_2	688..869	CDD:304668	54/207 (26%)
setx	XP_002936221.1	DEXXQc_SETX	1840..2157	CDD:350800	70/347 (20%)
		AAA_12	2128..2323	CDD:404073	53/204 (26%)
		PHA03247	<2365..2534	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910