Protein Alignment SMC6 and SMC3

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_005436.1
• Gene: SMC3 / 9126
• HGNCID: 2468
• Length: 1217
• Species: Homo sapiens
• Alignment Length: 1224
• Identity: 232/1224 - (18%)
• Similarity: 452/1224 - (36%)
• Gaps: 339/1224 - (27%)

  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLT---SSARATNRASSIQKLIKNGEVSATISITLSNSGL 178
            |....|.:||.||||||....|:...|:   |..|...|.:.:.:......:||.:.|...||..
Human    23 FSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDN 87

  Fly   179 R-PFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIRRMLLCFGINVENPIFVLNQEA 242
            | |...:    .:::.|.|......|.|..   |.|:|  :|:..:|...|.:..||.:::.|..
Human    88 RLPIDKE----EVSLRRVIGAKKDQYFLDK---KMVTK--NDVMNLLESAGFSRSNPYYIVKQGK 143

  Fly   243 AREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQLEKKKEMMIKHIAAEEEKL 307
            ..: :.....:...|||.:.....|......|..:|.:    |.|...:|...::|:|   ||:|
Human   144 INQ-MATAPDSQRLKLLREVAGTRVYDERKEESISLMK----ETEGKREKINELLKYI---EERL 200

  Fly   308 SILEDKEMVKENLQQCKTKLAW------MAVTSYQNELNNLEHSIKLIENKKASLEQTTSKKEST 366
            ..||::   ||.|.|.:   .|      :..|.|..|||          ..:|.|::.::|:|::
Human   201 HTLEEE---KEELAQYQ---KWDKMRRALEYTIYNQELN----------ETRAKLDELSAKRETS 249

  Fly   367 ----------QATMNQKLKEFEASKNQI---LATQKFQDERLKTAK----KAVQDLLLEASQVKA 414
                      |.....|:::.|....::   ::..|.:.|:|...:    |....|.|:|..::.
Human   250 GEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQD 314

  Fly   415 KI-GNAERR---MREDQR---SYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKSEEII 472
            :: ||:|:|   ::|.|:   ..:|.:|.:......||.|.|:.|....::....::  :::...
Human   315 ELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQE--RTDLYA 377

  Fly   473 AQLRAEQ--------QEIKRDITSVQERLDAVKNGRIQLHKSKQNISWEIEALSRNKSNKLSVYG 529
            .|.|..|        :.||:::.|:.:.::..|.....:||       ::|....||...|..|.
Human   378 KQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHK-------DLEDTEANKEKNLEQYN 435

  Fly   530 --EQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPK----------YRDLIENQLMHCLRSF 582
              :|.:..|.|        .:..:.|    :|....|.|          :|:  ||.....|.:.
Human   436 KLDQDLNEVKA--------RVEELDR----KYYEVKNKKDELQSERNYLWRE--ENAEQQALAAK 486

  Fly   583 IVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNK-VQPTTPN--TTVLIDEISCDD 644
            ....::::|.|||........|     |.|  .::|.|..|.| :.....|  ..::::...|:.
Human   487 REDLEKKQQLLRAATGKAILNG-----IDS--INKVLDHFRRKGINQHVQNGYHGIVMNNFECEP 544

  Fly   645 PV-----------VMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLE--YI 696
            ..           :..:::|...:.|.::.|..::         |:|..:|.:.:..|.:.  ..
Human   545 AFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKM---------NLPGEVTFLPLNKLDVRDTAY 600

  Fly   697 PSPNYAVYSTRITPARYIQKNVDDRIRQL--------QMEQSDLQEKE-----PSLEIDYMQHKK 748
            |..|.|:  ..|:..|| ....|...:.:        .||.|....:.     .:||.|.:.|:.
Human   601 PETNDAI--PMISKLRY-NPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRG 662

  Fly   749 VLE-----------NTQKVISQKSTMIGQHQSR-NQKAMQKIMELQNFDYQELPEYDRLKSHLAD 801
            .|.           ..||.:.:....:|:.::: |:...:.|..:.|       |.|:|.:.:..
Human   663 ALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINN-------EIDQLMNQMQQ 720

  Fly   802 SGEKIEKCRLEREMLQEKLLSIQHRQTELESTEAEERRALEGINKKLTALDTEAGEVESKMRS-- 864
            ...:..|.:..|:.:..::..::.::.:.|.|...::|:|:.:...|.|:::....:::::.:
Human   721 IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDL 785

  Fly   865 -LDLHYEENTR------RFQKTLQLERKMLGEK----------ETVLSE-----LEKARTEAEKL 907
             ..|..|:..|      ..::..|..|::|.|:          ||.|:|     |::...|..:|
Human   786 LSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNEL 850

  Fly   908 ----GEFIATTQTEEKIREAIS-RYKSKIKQVEELNYNPEELERGLAELRDELE----LQSRHLA 963
                |..:.|..|.|  .|||: |.|..:.:.|:|:.:.::.|.|:.||:..:|    ::..|:.
Human   851 RETEGGTVLTATTSE--LEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMD 913

  Fly   964 VVDSVVKKLRMAYHQRAQLFQRSR------HHYFTMVQFQFE--QALAMRQFKVSFE-------- 1012
            .::...|:|....:::..|.::..      ....::.|..||  |.|:::|.....|
Human   914 AINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKK 978

  Fly  1013 ---------------TSDKEKTWK---------------INVFP--------------------- 1026
                           :..|||..|               :||..
Human   979 YSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEV 1043

  Fly  1027 -----PSGNET--------------------------SNTRS----------------------- 1037
                 |.|..|                          |.::|
Human  1044 FQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGE 1108

  Fly  1038 ------LSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILI 1085
                  ||||::|...::|:..:......|||..||.|...|..:||.::::::
Human  1109 MREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	35/134 (26%)
		SMC_prok_B	115..1076	CDD:274008	230/1213 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	20/114 (18%)
SMC3	NP_005436.1	SMC_N	2..1197	CDD:426784	232/1224 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..268		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1059..1090		2/30 (7%)