Protein Alignment SMC6 and ATSMC2

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_001325474.1
• Gene: ATSMC2 / 823900
• AraportID: AT3G47460
• Length: 1174
• Species: Arabidopsis thaliana
• Alignment Length: 1219
• Identity: 258/1219 - (21%)
• Similarity: 441/1219 - (36%)
• Gaps: 385/1219 - (31%)

  Fly   117 FGPNINFLVGNNGSGKSAVITAL--ALGLTSSARATNRASSIQKLI-KNGEVS---ATISITLSN 175
            |.|:.|.:.|.||||||.::.::  .||:|:..:.  ||:::|:|: |.|:..   ||:|:|..|
plant    23 FDPHFNAITGLNGSGKSNILDSICFVLGITNLQQV--RAANLQELVYKQGQAGITRATVSVTFDN 85

  Fly   176 S--GLRPFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIRRMLLCFGINVENPIF-- 236
            |  ...|...:... .:||.|||........|  ..||..  :.:.::.:.....:||.||.|
plant    86 SERNRSPLGHEDHS-EITVTRQIVVGGKNKYL--INGKLA--QPNQVQNLFHSVQLNVNNPHFLI 145

  Fly   237 -------VLNQEAAREFLKELEPASNYK------------LLMKATQLDVCTSSLTE-----CHA 277
                   |||.: ..|.|..||.|:..:            |..|.|::|.....|.:     ...
plant   146 MQGRITKVLNMK-PMEILSMLEEAAGTRMYENKKEAALKTLEKKQTKVDEINKLLEKDILPALEK 209

  Fly   278 LRRHFTQ---------ELEQLEK--------------------KKEMMIKHIAAEEE-------- 305
            |||..:|         ||::|::                    .:||.||....:|:
plant   210 LRREKSQYMQWANGNAELDRLKRFCVAFEYVQAEKIRDNSIHVVEEMKIKMTGIDEQTDKTQGEI 274

  Fly   306 --------------------KLSILEDK-EMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLI 349
                                ::..|.|| :.:...:.:..:||..|..| .|.|..|.|..:..|
plant   275 SELEKQIKALTQAREASMGGEVKALSDKVDSLSNEVTRELSKLTNMEDT-LQGEEKNAEKMVHNI 338

  Fly   350 ENKKASLEQTTS---KKESTQATMNQKLKEF-------EASKNQILATQKFQDERLKTAKKAVQD 404
            |:.|.|:|:..|   |.:...|.:.||.:||       |.....|||.:...||     :|.::|
plant   339 EDLKKSVEERASALNKCDEGAAELKQKFQEFSTTLEECEREHQGILAGKSSGDE-----EKCLED 398

  Fly   405 LLLEASQVKAKIGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKSE 469
            .|.:|   |..:|.||..:::.......|||             |.:|:   |.:::.||    :
plant   399 QLRDA---KISVGTAETELKQLNTKISHCEK-------------ELKEK---KSQLMSKQ----D 440

  Fly   470 EIIAQLRAEQQEIKRDITSVQERLDAV--KNGRIQLHKSKQNISWEIEALSRNKSNKLSVYGEQT 532
            |.:| :..|....|.|:.||:...|::  |.|             ::|||.:::.::|.: |.:.
plant   441 EAVA-VENELDARKNDVESVKRAFDSLPYKEG-------------QMEALEKDRESELEI-GHRL 490

  Fly   533 IQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIEN----QLMHCLRSFIVGSDRERQSL 593
            ...||.|..|.|....                 .|||.::|    ::...:...|..:||...:.
plant   491 KDKVHELSAQLANVQF-----------------TYRDPVKNFDRSKVKGVVAKLIKVNDRSSMTA 538

  Fly   594 --------------------RALLQ-------------NKFQG-----------------GN--- 605
                                :.|||             ||.|.                 ||
plant   539 LEVTAGGKLFNVIVDTEDTGKQLLQKGDLRRRVTIIPLNKIQSHLVPPRVQQATVKLVGKGNAEL 603

  Fly   606 --------------MPTIITSPF----TDRVYDVSRNKVQPTTPNTTVLIDEISCDDPV------ 646
                          |..:..|.|    ||...:|:.|: :..||:.|:..|.......:
plant   604 ALSLVGYSEELKNAMEYVFGSTFVCKTTDAAKEVAFNR-EIRTPSVTLEGDVFQPSGLLTGGSRK 667

  Fly   647 ----VMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLEYIPSPNYAVYSTR 707
                ::..|.|:...||......|.::| :.::.:.:.|..|:.......||      ..:|...
plant   668 GGGDLLRQLHDLAEAETKFRAHQKSLSE-IEANIKELQPLQTKFTDMKAQLE------LKMYDMS 725

  Fly   708 ITPARYIQK---NVDDRIRQLQME----QSDLQEKE----------PSLEIDYMQHKKVLENTQK 755
            :...|..|.   .:.|.:::|:.|    :|.::|||          .:||.....|.|..|...|
plant   726 LFLKRAEQNEHHKLGDAVKKLEEEVEEMRSQIKEKEGLYKSCADTVSTLEKSIKDHDKNREGRLK 790

  Fly   756 VISQKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCRLEREMLQEKL 820
            .:           .:|.|.::..::..:   ::|..::.::..|....|.:.:   |:..|:.:|
plant   791 DL-----------EKNIKTLKARIQASS---KDLKGHENVRERLVMEQEAVTQ---EQSYLKSQL 838

  Fly   821 LSIQHRQTELESTEAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQ---- 881
            .|::.:.:.|.|....:|..::.|.|......:|...:.:||:..|.....:....:|.||
plant   839 TSLRTQISTLASDVGNQRAKVDAIQKDHDQSLSELKLIHAKMKECDTQISGSIAEQEKCLQKISD 903

  Fly   882 --LERKMLGEKETVLSELE--KARTEAEKLGEFIATTQTEEKI---------REAISRYKSKIKQ 933
              |:||.| |.|....|:|  ....:.:||.|......:|:::         .|:...:|::
plant   904 MKLDRKKL-ENEVTRMEMEHKNCSVKVDKLVEKHTWITSEKRLFGNGGTDYDFESRDPHKAR--- 964

  Fly   934 VEELNYNPEELERGLAELRDELELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHY-FTMVQFQ 997
                    |||||          ||:...::...|.||:       ..:|:::...| ..|.:..
plant   965 --------EELER----------LQTDQSSLEKRVNKKV-------TAMFEKAEDEYNALMTKKN 1004

  Fly   998 FEQALAMRQFKVSFETSDKEK-----TW-KIN-----VF------------PPSGNE-------- 1031
            ..:....:..||..|..:|:|     || |:|     :|            ||.|..
plant  1005 IIETDKSKIKKVIEELDEKKKETLKVTWVKVNQDFGSIFSTLLPGTMSKLEPPEGGTFLDGLEVR 1069

  Fly  1032 -------TSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTD 1073
                   ..:...||||:||...:||:..|......|.|.|||.|...|
plant  1070 VAFGDVWKQSLSELSGGQRSLLALSLILALLLFKPAPIYILDEVDAALD 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	43/147 (29%)
		SMC_prok_B	115..1076	CDD:274008	258/1219 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	18/62 (29%)
ATSMC2	NP_001325474.1	SMC_N	2..1165	CDD:481474	258/1219 (21%)