Protein Alignment SMC6 and Smc6

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_079971.2
• Gene: Smc6 / 67241
• MGIID: 1914491
• Length: 1097
• Species: Mus musculus
• Alignment Length: 1154
• Identity: 312/1154 - (27%)
• Similarity: 555/1154 - (48%)
• Gaps: 151/1154 - (13%)

  Fly    29 KRSKQQFVAEAEPDFVEEE-TEKYANASTSQTARSRNKQARQTTLNMSQRSVNFNLTSELSIPNA 92
            ||.:|:.:.:.:.|..|:| |..:.|.:::.||                        :|:.|
Mouse    16 KRPRQEELEDFDKDGDEDECTISFTNGTSTLTA------------------------AEVGI--- 53

  Fly    93 FDRCGKVISMRLTNFMCHSNLF-IEFGPNINFLVGNNGSGKSAVITALALGLTSSARATNRASSI 156
                  :.|::|.||||||.|. .:||.|:||:|||||||||||:|||.:||...|.||||.||:
Mouse    54 ------IESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSL 112

  Fly   157 QKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQIR-HSSSTYDLQDARGKSVSKKVSDI 220
            :..:|.|:.||.|||||.|.|...|:|:::|..:.|.:.|. ..|.:|.|:..:|..||.:..::
Mouse   113 KGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEEL 177

  Fly   221 RRMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQE 285
            ..:|..|.|.|:||:.||.||.:::||:.......||..||||||:......:.....:....::
Mouse   178 IAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQ 242

  Fly   286 LEQLEKKKEMMIKHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIE 350
            :.|.|::...:.:....:||:...:.....:|.||:..|.::||..|...:.:||.:..:||:.|
Mouse   243 INQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGE 307

  Fly   351 NKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLLEASQVKAK 415
            .:.|.|::   |.|..|..:|...|:::..::::   :|..:|   |..:|.:.:.|:...:..
Mouse   308 ERAAKLDR---KMEEQQVRLNDAEKKYKDIQDKL---EKISEE---TNARAPECMALKTDVIAR- 362

  Fly   416 IGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKS------------ 468
                       .|::::.|.|......::..:.:..|:...:||.|||...:|
Mouse   363 -----------TRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRI 416

  Fly   469 ---EEIIAQLRAEQQEIKRDITSVQERL--DAVKNGRIQLHKSKQNI---------SWEIEALSR 519
               :|.:..|:.::..:.::....::.:  |..::||::    |::|         ..:::.|..
Mouse   417 CWLKEKVKALQDQEHTVNQEAEQFEQAIEKDKQEHGRVR----KEDIEVRHALNYNQRQLKELKD 477

  Fly   520 NKSNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIENQLMHCLRSFIV 584
            :|:::|..:|.....::.|:...|........|.||||..|...:|:....||:.|...|:::..
Mouse   478 SKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCC 542

  Fly   585 GSDRERQSLRALLQNKF--QGGNMPTIITSPFTDRVYDVS-RNKVQPTTPNTTVLIDEISCDDPV 646
            .:..:.:.|::|:: ||  .|.:.|.||.|.|.|.||||. |....|..|  ||| ..:..|:.|
Mouse   543 HNHADERVLQSLMK-KFYPPGTSRPQIIVSEFRDEVYDVRLRAAYHPEFP--TVL-TALEIDNAV 603

  Fly   647 VMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLEYIPSPNYAVYSTRITPA 711
            |.|.|||:..|||||:.::..:|..:....:  ||...|......|.:......|:..|||   .
Mouse   604 VANSLIDMRSIETVLLIKNNSVARAVMQSQK--PPKNCREAFTADGDQVFAGRYYSSESTR---P 663

  Fly   712 RYIQKNVDDRIRQLQMEQSD-------LQEKEPSLEIDYMQHKKVLENTQ---KVISQKSTMIGQ 766
            :::.::||..|..|:.|..:       ||::..:||.|..:::::|:..|   |.|..|.
Mouse   664 KFLSRDVDSEISDLETEIENKKGHIITLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKI----- 723

  Fly   767 HQSRNQKAMQKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCRLEREMLQEKLLSIQHRQTELE 831
                 :|.:.:|.||:|.:..:..:...|:....::  ||:...:|:.|.|:|     .....|:
Mouse   724 -----RKNISEIRELENIEEHQSVDIATLEDEAEEN--KIKMQMVEKNMEQQK-----ENMENLK 776

  Fly   832 STEAEERRALEGINKKLTALDTEA-----------GEVESKMRSLDLHYEENTRRFQKTLQLERK 885
            |.:.|.....:.|..|:..|...|           .||:|:.|... |||:..:....||..:|:
Mouse   777 SLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQ-HYEDKQKEHLDTLNKKRR 840

  Fly   886 MLGEKETVLSELEKARTEAEKL-GEFIATTQTEEKIREAISRYKSKIKQVEELNYNPEELERGLA 949
            .|..||   .||::..::|.:: .|.|...::...:.:.|:|.:.||:.....:.:.||:.:...
Mouse   841 ELDMKE---KELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQ 902

  Fly   950 ELRDE-LELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHYFTMVQFQFEQALAMRQF--KVSF 1011
            |.|:. |:|.:: :..:...:|.|......|.:.:|:.|.......:..|:..|:.|.:  |::|
Mouse   903 EARETYLDLDNK-VRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNF 966

  Fly  1012 ETSDKEKTWKINVFPPSGNETS--NTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDE 1074
            :  .|.:|..|.|.|..||:.|  :.|:||||||||:||..:..|||.::.||..|||:||:.|.
Mouse   967 D--HKNETLSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDM 1029

  Fly  1075 VNRKFITEILIGEGLEWLSRQYCFLTPQD-TKVEASNLITVHKLEAPER 1122
            |||:...::::........||:..||||. :.:.:|.||.:.::..|||
Mouse  1030 VNRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPER 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	70/150 (47%)
		SMC_prok_B	115..1076	CDD:274008	276/1017 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	38/97 (39%)
Smc6	NP_079971.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		4/15 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	54..>210	CDD:476819	71/155 (46%)
		SMC_prok_B	<221..1055	CDD:274008	213/891 (24%)
		Flexible hinge	458..667		60/217 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	813..839		9/26 (35%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<983..1081	CDD:476819	39/96 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1078..1097		1/1 (100%)