Protein Alignment SMC6 and SMC1

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Alignment Length: 1230
• Identity: 243/1230 - (19%)
• Similarity: 442/1230 - (35%)
• Gaps: 335/1230 - (27%)

  Fly   102 MRLTNFMCHSNLFIEFGP--NINFLVGNNGSGKSAVITALALGL---TSSARATN-----RASSI 156
            :.:.||..:.. .|..||  ..|.::|.||||||..:.|::..:   |||.|...     ..|||
  Fly    30 IEMENFKSYRG-HIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGSSI 93

  Fly   157 QKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIR 221
            .|.:.. ....|....|:..           .|:...|.:...||.|.:   .|:|||.  |...
  Fly    94 GKPVSR-SCYVTAKFVLNEE-----------RHMDFQRAVIGGSSEYRI---NGESVSS--STYL 141

  Fly   222 RMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQL--DVCTSSLTECHALRRHFTQ 284
            ..|...||||:...|::.|.|.....        .|...:.|.|  ::..|.|.:
  Fly   142 NKLEKIGINVKAKNFLVFQGAVENIA--------MKTPKERTALFEEISGSGLLK---------- 188

  Fly   285 ELEQLEKKKEMMIKHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELN--------- 340
              :...:.|:.||  :|.||.:.:..:.|.:..|..:....|:.....|..|||.|
  Fly   189 --DDYNRLKQEMI--VAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLF 249

  Fly   341 --------------NLE---HSIKLIENKKASLEQTTSKKESTQ-------ATMNQKLKEFEASK 381
                          :||   ..:|.:|.:|.:.::...:|:...       |.::|:::|||...
  Fly   250 RLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQM 314

  Fly   382 NQILATQKFQDERLKTAKKAVQDL--LLEASQVKAKIGNAERR-MREDQRSYDECEKLIGNYHAD 443
            |:.........|::...||.:..|  .||.::   :..||.:. :|:.::...:.|.|...:..:
  Fly   315 NKRRPLYIKAKEKVTHCKKKLISLQKTLETAR---EADNAHQSDIRKLEKQLADVEALKKRFEDE 376

  Fly   444 FNRVNEQREENANKIEMLKKQV----VKSEEIIAQLRAEQQEIKRDITSVQERLDAVKNGRIQLH 504
            ....:::|.::.|..|.|.::.    .::|....|.|:|...:.|:..|.|:.||...|.|..:.
  Fly   377 IENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVE 441

  Fly   505 KSKQNISWE-IEALSRN-------KSNKLSVYGEQTIQVVHALRTQYAGSNMHRMP--------- 552
            :|.:.::.: .||:.|.       ||::.::  |:..::...||.. .|::..::.
  Fly   442 ESFKKLTLQREEAVKRRDKLMDHIKSSQAAL--EEQNRIKDELRRD-VGTSKEKIAEKQRELEDV 503

  Fly   553 RGPLGQYISAPNPKYRDLIENQLMHCLRSFIVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDR 617
            |..||   .|.:.|:.|               ...:::|.:..|.:.:..|
  Fly   504 RDQLG---DAKSDKHED---------------ARRKKKQEVVELFKKQVPG-------------- 536

  Fly   618 VYDVSRNKVQPTTPNTTVLI--------DEISCDDPVVMNYLIDILR-----IETVL---VTESK 666
            |||...|..|||.....|.:        :.|..|......:.|.||:     :||.|   ..:.|
  Fly   537 VYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVK 601

  Fly   667 EIAEFL--TSDTENV----------PPNLTRVLVPNLGLEYI-PSPN------YAVYSTRITP-- 710
            .:.|.|  .||..||          |..:.|.::...|...: .:|.      |.:..:|...
  Fly   602 PLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALA 666

  Fly   711 -------------------ARYIQKNVDDRIRQLQMEQSDLQE----------KEPSLEIDYMQH 746
                               ||..::..:..:.||:|::..|||          |:..|.....|.
  Fly   667 LDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQI 731

  Fly   747 KKV----------LENTQKVISQKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKSHLAD 801
            |.:          ||:::|.|||....:.|.||:..:...||:|::............:|.::.:
  Fly   732 KGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNN 796

  Fly   802 SGEKI--EKCRL----------ERE--MLQEKL-------------------------------- 820
            ..:|:  ..||.          |||  |.||:.
  Fly   797 VEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERW 861

  Fly   821 -LSIQHRQTELESTEAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTL---- 880
             .|:|..:..||..:..|.|.|:.|::....::....:.::|.:::| ..||:..:.:|.:
  Fly   862 ERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVD-DMEEDISKARKDVANLA 925

  Fly   881 -----------QLERKMLGEKETVLSELEKARTEA-------EKLGEFI--------ATTQTEEK 919
                       .:|.|:..:|....:.|.:|:|:.       ..|.:.:        :|:...|.
  Fly   926 KEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMEN 990

  Fly   920 IRE----AISRYKSKIKQVEELNYNPEELERGLAELRDELE-LQSRHL-------AVVDSV---- 968
            |.|    ::.|..:|:|.........|.|::.|....|.|| :|:.::       ||.:.|
  Fly   991 IIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTN 1055

  Fly   969 ---------VKKLRMAY----HQRAQLFQRSRHHYFTMVQFQFEQALAMRQFKVSFETSDKEKTW 1020
                     .|:.:.|:    ::|:..|.....|....:...:::.......:......:.|:.:
  Fly  1056 EEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPY 1120

  Fly  1021 ----KINVFPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVN 1076
                ..|...| |.......:|||||::...::||....|....||:.|||.|...|..|
  Fly  1121 LDGINYNCVAP-GKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	42/155 (27%)
		SMC_prok_B	115..1076	CDD:274008	240/1215 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	18/50 (36%)
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	243/1230 (20%)