Protein Alignment SMC6 and smc1al

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_997975.2
• Gene: smc1al / 403060
• ZFINID: ZDB-GENE-040426-57
• Length: 1233
• Species: Danio rerio
• Alignment Length: 1293
• Identity: 258/1293 - (19%)
• Similarity: 484/1293 - (37%)
• Gaps: 363/1293 - (28%)

  Fly   102 MRLTNFMCHSNLFIEFGPNINF--LVGNNGSGKSAVITALALGLTSSARATN-RASSIQKLIKNG 163
            :.:.||..:....| .||...|  ::|.||||||.::.|::..|  :.:.:| |..:::.||...
Zfish     7 IEIENFKSYKGRQI-IGPFHKFTAIIGPNGSGKSNLMDAISFVL--AEKTSNLRVKTLKDLIHGA 68

  Fly   164 EVS------ATISITLSNSGLRPFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIRR 222
            .|.      |.:::.....|         |..|:..|.|..|||.|.:.:   |.|.  :||...
Zfish    69 PVGKPAANRAFVTMVYQQDG---------GQELSFSRIIIGSSSEYRINN---KVVG--LSDYSE 119

  Fly   223 MLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMK-------ATQLDVCTSSLTECH---- 276
            .|...||.::...|::.|.|. |.:....|.....|..:       |.:.|.|...:.:..
Zfish   120 ELEKLGILIKARNFLVFQGAV-ESIAMKNPKERTALFEEISRSGELAQEYDRCKKEMVKAEEDTQ 183

  Fly   277 ----------ALRRHFTQELEQLEK----KKEMMIKHI----------AAEEEKLS--------- 308
                      |.|:...||.|:.|:    |.|::..|:          .:|.|||:
Zfish   184 FNYHRKKNIAAERKEAKQEKEEAERYQRLKDEVVRAHVQLQLFKLYHNESEIEKLNRELAHRNKE 248

  Fly   309 ILEDK---EMVKENLQQCKTKLAWM---------AVTSYQNELN-----------NLEHSIKLIE 350
            |.:|:   :.|:|.|:..|.:|..|         .:.....|||           |..|.||.:|
Zfish   249 IDKDRKRMDRVEEELKDKKKELGRMMRDQQMIEKEIKEKDAELNQKRPLYIKAKENTAHKIKKLE 313

  Fly   351 NKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLLEASQVKAK 415
            ..:.||:......:..:..|::..:|..|.:   :|.|:|::...:.|:...|||.||.:||||.
Zfish   314 AARKSLQNAQKCYKKRKGDMDELDREQGAVE---MARQEFEERMEEEAQSQGQDLQLEENQVKAY 375

  Fly   416 IGNAERRMREDQRSYDECEKLIGNYHADFNRVN-EQR----------------EENANKIEMLKK 463
            ....|...:.......|.||...:..||.:|:: |:|                |||..:||.|:.
Zfish   376 HRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKIETEAKIKQKIREIEENQKRIEKLED 440

  Fly   464 QVVKSEEIIAQLRAEQQEIKRDITSVQERLDAVKNGRIQLHKSKQNISWEIEA-LSRNKSNKLSV 527
            .:..|.:.:.:.:..::|:..::...:.|:|.:   .::|::..:.:.   :| :.|.::::
Zfish   441 YITTSRQSLDEQKRMEEELTEEVEQAKRRIDEI---NMELNQVMEQLG---DARIDRQENSR--- 496

  Fly   528 YGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNP---KYRDLIENQLMHCLRSFIVGSDRE 589
             .::..:::.:::..|.||        ..|:.|....|   ||:..:...|...:.:.||  |.|
Zfish   497 -QQRKAEILESIKRLYPGS--------VYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIV--DSE 550

  Fly   590 RQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQPTTP------NTTVLIDEI-------- 640
            :.....:...|.|.|...|.:...:.:         |:||..      ...::||.|
Zfish   551 KTGRDCIQYIKEQRGEPETFLPLDYLE---------VKPTDEKLRELRGAKLVIDVIRYEPPQIK 606

  Fly   641 -----SCDDPVVMNYLIDILRI--------ETV------------------------------LV 662
                 :|.:.:|.:.:.|..||        :||                              .|
Zfish   607 KALQYACGNALVCDNVEDARRIAFGGPYRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAV 671

  Fly   663 TESKEIAEFLT----------------------------------SDTENVPPNLTRVLVPNLGL 693
            .:.|:..|.||                                  ||.|...   ||.|..|:..
Zfish   672 DKLKDRKEKLTDELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTK---TRHLSLNMQE 733

  Fly   694 EYIPSPNYAVYSTRITPARYI-------QKNVDDR--------------------IRQLQME--- 728
            :.......|.:..||...:.|       .|::.||                    ||:.:.|
Zfish   734 KSKLESELANFGPRINDIKRIIQSRERDMKDLKDRMNVVEDEVFVEFCKEIGVRNIREFEEEKVK 798

  Fly   729 ----------QSDLQEKEPSLEIDYMQHKKVLENTQKVISQKSTM---------IGQHQSRNQKA 774
                      :.:.|:...::::|| :..::.|:.:||:..:.|:         :.:.:.||.|.
Zfish   799 RQNEIAKKRLEFETQKTRLAIQLDY-EKNQLKEDQEKVVMWEQTVKKDENEIEKLKKEEQRNMKI 862

  Fly   775 MQKIM-ELQNFDYQELPEYDRLKSHLADSGEKIEKCR-------LEREMLQEKLLSIQHRQTELE 831
            :.:.| :||:...|.|.:    ||.:.|...::|:.|       .|...||:::.:|   :|:||
Zfish   863 IDETMAQLQDLKNQHLTK----KSEVNDKNHEMEEIRKKLGGANKELTQLQKEVTAI---ETKLE 920

  Fly   832 STEAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSE 896
            ...::....|:....:...|...:|.::      |:..||...:.:::|...:|   ...|||::
Zfish   921 QKRSDRHNLLQACKMQDIKLPLRSGTMD------DISQEEGNSQAEESLSSSQK---TSSTVLAK 976

  Fly   897 LEKARTEAEKLGEFIATTQTEEKIREAISRYKSKIKQVEELNY-----NPEELERGLAELRDELE 956
            ......:...|.|.:..:.::|:|:..::..:.::.:.:.:..     |.:.:|: |..:||:.:
Zfish   977 EALIEIDYNSLSEDLKDSLSDEEIKAEMNTLQQRLNEQQSILQRISAPNMKAMEK-LESVRDKFQ 1040

  Fly   957 LQSRHLAVVDSVVKKLRMAYHQ-RAQLFQRSRHHYFTMVQFQFEQ---ALAMRQFKVSF---ETS 1014
            ..|..........||.:.|:.| :.:.|.|. |..|..|....::   ||:......:|   |..
Zfish  1041 ETSDEFEAARKRAKKAKQAFEQIKKERFDRF-HACFESVATNIDEIYKALSRNSSAQAFLGPENP 1104

  Fly  1015 DKEKTWKINV--------FPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVF 1071
            ::.....||.        |.|..|       |||||::...::||..:.|....||:.|||.|..
Zfish  1105 EEPYLDGINYNCVAPGKRFRPMDN-------LSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAA 1162

  Fly  1072 TDEVNRKFITEILIGEGLEWLSRQ-------YCFLTPQDTKVEASNLITVHKLEAPER 1122
            .|..|        ||:...::..|       ......::...:|.:||.|:    ||:
Zfish  1163 LDNTN--------IGKVANYIKDQSVQNFQAIVISLKEEFYTKADSLIGVY----PEQ 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	41/154 (27%)
		SMC_prok_B	115..1076	CDD:274008	246/1225 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	26/101 (26%)
smc1al	NP_997975.2	SMC_N	3..1211	CDD:426784	258/1293 (20%)