Protein Alignment SMC6 and SMC2

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Alignment Length: 1225
• Identity: 251/1225 - (20%)
• Similarity: 465/1225 - (37%)
• Gaps: 322/1225 - (26%)

  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLTSSARATNRASSIQKLI-KNGE---VSATISITLSNS- 176
            |.|....:.|.||||||.::.::...|..|.....|||::|.|: |||:   ..||::|...|:
  Fly    23 FDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTN 87

  Fly   177 ------GLRPFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSV-SKKVSDIRRMLLC-FGINVEN 233
                  |....:      .::|.||:........|  ..||.| :|||.|    ..| ..:||.|
  Fly    88 PAQCPQGYEKCR------EISVTRQVVVGGKNKFL--INGKLVQNKKVQD----FFCSIQLNVNN 140

  Fly   234 PIF---------VLNQEAAREFLKELEPA---SNYKLLMKATQ--LDVCTSSLTECHAL------ 278
            |.|         |||.: .:|.|..:|.|   |.||....||:  ::...:.:.|...|
  Fly   141 PNFLIMQGKIQQVLNMK-PKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEVL 204

  Fly   279 --------RRHFTQELEQLEKKKEMMIK-HIAAEE----EKLSILEDKE-MVKENLQQCKTKLA- 328
                    .|...||.:::.:..:.:|: ||:|:.    |.|..:|..| .:::.:..||...|
  Fly   205 PKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAK 269

  Fly   329 -WMAVTSYQNELNNLEH--------SIKLIENK---KASLEQT-TSKKESTQATMNQKLKEFE-A 379
             ...|.|.:|.:..::.        |||.:|.:   |.:||.| |...::.|.|:.|..|:.. |
  Fly   270 NLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMA 334

  Fly   380 SKNQILATQKFQDERLKTAKKAVQDLLLEASQVKAKIGNAERRMREDQRSYDECEK--------L 436
            |||       .:|:....|||..     :.::|:.:..:.:.....|.::|::.:|        |
  Fly   335 SKN-------IEDDERALAKKEA-----DMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGL 387

  Fly   437 IGNYHADFNRVNEQ----REE--------NANKIEM------LKKQ----------VVKSEEIIA 473
            ..|.:.:.:.:.||    :|:        ..::||:      ||::          .||.:::..
  Fly   388 STNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHD 452

  Fly   474 QLRAEQQEIKRDITSVQ---ERLDAVKNGRIQLHKSKQNISWEIEALSRNKSNKLSVYGEQTIQV 535
            ||..|.:.::|.:.|:.   ...:.:|..|..||..|:::..|::..:.::
  Fly   453 QLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASR-------------- 503

  Fly   536 VHALRTQYAGSNM-HRMPRGPLGQYISAPNPKYRDLIENQLMHCLRSFIVGSDRERQSL--RALL 597
             :.|:.|....|. .|..||.:|:.....:.:....:.......|.|::...|...:.:  |..|
  Fly   504 -YDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNL 567

  Fly   598 Q--------NKFQGGNMPTIITSPFTDRVYDVSRNKVQPTTPNTTV-LIDEISCDDPVVMNYLID 653
            |        ||.|.|::        ...|.:.::|||........: |||.....:||:......
  Fly   568 QRRVTLIPINKIQSGSL--------NRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGG 624

  Fly   654 ILRIETVLVTESKEIA-------EFLTSDTENVPPNLTRVLVPNLGLEYIPSPNYAVYSTRITPA 711
            .|..:.::|  :|:|:       ..:|.:.:.|.|:.|            .|...|.....:...
  Fly   625 TLICKDLIV--AKQISYDPRINCRSVTLEGDVVDPHGT------------VSGGAAPKGANVLEE 675

  Fly   712 RYIQKNVDDRIRQLQMEQSDLQEKEPSLEIDYMQHKKVLEN----------TQKVISQKSTMIGQ 766
            .:..|.::...|::..|.:.::::..|:|...:...|:.||          .:..::|.:....|
  Fly   676 LHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQ 740

  Fly   767 HQSRNQKAMQKIMELQNFDYQELPEYDRLK-----SHLAD------------------SGEKIEK 808
            .:....:...|.:|.|..|.:|..:..:.|     :.|||                  :.::.||
  Fly   741 AEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEK 805

  Fly   809 CRL---EREMLQEKL-LSIQHRQTELESTEAEERRALEGINKKLTALD----------TEAGEVE 859
            .|.   :||...|.| |.|...|..:|:.:.:.:..::.:.|....||          :|..|:|
  Fly   806 SRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELE 870

  Fly   860 SKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSELEKARTEAEKLGEFIATTQTEEKIR-EA 923
            ..::.......:..:..:..|..:.|||.|.:.:..|::|...|.:|    |::...|.|.| ||
  Fly   871 QAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKK----ISSDAKEAKKRMEA 931

  Fly   924 I------------------SRYK----------SKIKQVEELNYNPEELERGL-----------A 949
            :                  :||.          :|:.:::|   ..:::||.|           .
  Fly   932 LEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQE---KKDKMERTLNMNAIMVLDREE 993

  Fly   950 ELRDELELQSRHLAVVDSVVKKL--RMAYHQRAQLFQRSRHHYFTMVQFQF-------------- 998
            |...|.|.:...:|:....:||:  :|...::.||.:.:     |.|...|
  Fly   994 ENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAA-----TEVNTNFSGIFSSLLPGAEAK 1053

  Fly   999 ------EQALAMRQFKVSFETSDKEKTWKINVFPPSGNETSNTRSLSGGERSFTTVSLLKGLWST 1057
                  ...|...:.||.|     ...||           .:...||||::|...:||:..:...
  Fly  1054 LNPVHTNGCLTGLEIKVGF-----NGIWK-----------ESLGELSGGQKSLVALSLVLAMLKF 1102

  Fly  1058 SDHPFYFLDEYDVFTDEVNRKFITEILIGEGLEWLSRQYCFLTPQDTKVEASNLI 1112
            |..|.|.|||.|...|..:.:.|..:|   ...:.:.|:..::.:|.....:|::
  Fly  1103 SPAPLYILDEVDAALDMSHTQNIGSML---KQHFTNSQFLIVSLKDGLFNHANVL 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	45/152 (30%)
		SMC_prok_B	115..1076	CDD:274008	246/1187 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	20/86 (23%)
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	251/1225 (20%)