Protein Alignment SMC6 and glu

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Alignment Length: 1269
• Identity: 238/1269 - (18%)
• Similarity: 478/1269 - (37%)
• Gaps: 355/1269 - (27%)

  Fly   115 IEFGP---NINFLVGNNGSGKSAVITALALGLTSSARATNRASSIQKLIKNGEVSATISITLSNS 176
            :|.||   :...::|.||||||.||.::.  .....|| ||       |:...||..|..:.|..
  Fly   104 VELGPFHQSFTAIIGPNGSGKSNVIDSMM--FVFGCRA-NR-------IRCKRVSTLIHSSSSYP 158

  Fly   177 GLRP------FK----------ADIFGPHLTVVR-QIRHSSSTYDLQDARGKSVSKKVSDIRRML 224
            .||.      ||          .|:....:.:.| .:..:||.|.:.|.|.     ::.|:.::|
  Fly   159 NLRSCSVAVHFKQIVDKGDGTCEDVPDSSIVIERTAMSDNSSYYQINDKRA-----QLKDVAKLL 218

  Fly   225 LCFGINVENPIFVL------------------NQEAAREFLKELEPASNY-KLLMKATQ-LDVCT 269
            ....:::|:..|::                  |:....|:|:::.....| :.|.:..| :|..|
  Fly   219 KKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEYLEDIVGTQRYIRPLQQINQRVDQLT 283

  Fly   270 SSLTECHALRRHFTQELEQLEKKKEMMIKHIAAEEEKLSILEDKEM-VKENLQQCKTKLAWMAVT 333
            ...||.|...:...:|::.||:.....:.::..|.|   ::..|.. :::.:...|:||     .
  Fly   284 DDRTEKHNRCKLAEREMKDLEQPFNEAVDYLKKENE---LVRTKSFHIQKIISIKKSKL-----E 340

  Fly   334 SYQNELNNLEHSIKLIENKKASLEQTTSKKESTQATMNQKLKEFEA---SKNQILATQKFQDERL 395
            .|..|.......:|..:...|:|:|:.::||:   .:.::::|:||   .:.||       .:||
  Fly   341 QYTQEHEACAEELKTHDEGTAALKQSRAEKET---IIRKEIEEYEALVKKREQI-------KKRL 395

  Fly   396 KTAKKAVQDLLLEASQVKAKIGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANK--- 457
            .|.:.|.       :::::.:.|..::.::|:...::.||.:.:.| .....|::..|:.||
  Fly   396 VTVESAY-------TEIQSTMENTNKQRKKDKAQIEKNEKELEDLH-KLPEKNQREIEDCNKKLE 452

  Fly   458 ---------IEMLKKQVVKSEEIIAQLRAEQQEIKRDITSVQERLDAVKNGRIQLHKSKQNISWE 513
                     .|.|:||..:..:..|.|..::.::..::..::|:::..| |.:|:.:|:..|..:
  Fly   453 SLEVSKVTLNEELEKQQAELTKTTAPLTEKRLKLSDELVGLKEKVNTAK-GEVQVFESQLKILKQ 516

  Fly   514 IEALSRNKSNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIE---NQL 575
            .|.....|...|....||:.:.:....|: .......:||  :...|::.:.:...:::   |..
  Fly   517 AETTESRKYETLKSSYEQSQKSLEEKVTR-VDELKESIPR--MKTEIASKSAEVDKMVKEERNLS 578

  Fly   576 MHC--------LRSFIVGSDRERQS-----LRALLQNKFQG-----------------------G 604
            |.|        .||.::.:.|....     :|..::.|..|                       |
  Fly   579 MQCNKLRTEINERSSVMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACG 643

  Fly   605 NMPTIITSPFTD--------RVYDVSR------NKVQ----------PTTPNTTVLIDEISCDDP 645
            .:..|:|..:..        :.|:|.|      :|::          .|..|...|.|.:..:|.
  Fly   644 RLDNIVTDNYETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDD 708

  Fly   646 VVMNYLIDILRIETV------------------LVTESKEIAEFLTSDTENVPPNLTRVLVPNLG 692
            .|.......||...|                  :||...|:.|.    |..:....:|.:...:|
  Fly   709 RVRTAFYFALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEMIEM----TGTMSGGGSRPIRGKMG 769

  Fly   693 LEYIPSPNYAVYSTRITPARYIQKNVDD---RIRQLQMEQSDLQEKEPSLE-----------IDY 743
            .:.......:..|::|:     ||.::|   :..:||...:..||::.|||           .|.
  Fly   770 TQVRTKTAESADSSQIS-----QKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDE 829

  Fly   744 MQHKKVLENTQKVISQKSTMIGQHQSRNQKAMQK------------------------------- 777
            .::|::..:...:..|.::.:.|.:::.|:.::|
  Fly   830 AEYKRLAVSITSLEQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAV 894

  Fly   778 ---IMELQNFDYQELPEYDRLKSHLADSGE-KIEKCRLEREML---------------------- 816
               |.|:||       :||.|::......| ||:|...:.|.|
  Fly   895 SSQIEEIQN-------QYDTLRNESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKIT 952

  Fly   817 -------------QEKLLSI-------QHRQTELESTEAEERRALEGINKKLTALDTEAGEVESK 861
                         :|||.|:       :.::.|||....|...::||...:.:.:..|..|:..
  Fly   953 GNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITK- 1016

  Fly   862 MRSLDLHYEENTRRFQKTLQLERKM---LGEKETVLSELE--KARTEAEKLGEFIATTQTEEKIR 921
                    |||.|..:: ::::.|:   .|:...|.:::.  :|:....||.|....|:.:..::
  Fly  1017 --------EENKRNIER-IEIDTKLQAAAGKMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLK 1072

  Fly   922 EAISRYKSKIKQVEELNYNPEELERGLAELRDEL----ELQSRHLAVVDSV-------------- 968
            | ::..:.:.:.:|.|.|....||..|...:..|    |...:.|..:|.|
  Fly  1073 E-LNEEELEAETLEALQYKQTMLEEDLKTKKPNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMR 1136

  Fly   969 -----VKKLR-MAYHQRAQLFQRSRHHYFTMVQF----QFEQALAMRQFK--VSFETSDKEKTWK 1021
                 |:|.| ..:.....:..|.....:.|:..    :.|...:|..|.  |:|.....:|:||
  Fly  1137 DKYEEVRKRRYKEFMDGFSIITRKLKEMYQMITLGGDAELELVDSMDPFTEGVNFTVRPPKKSWK 1201

  Fly  1022 INVFPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILIG 1086
            .         .||   |||||::.::::|:..|......|.||:||.|...|     |....::|
  Fly  1202 Y---------ISN---LSGGEKTLSSLALVFALHYYKPSPLYFMDEIDAALD-----FKNVSIVG 1249

  Fly  1087 EGLEWLSR--QYCFLTPQDTKVEASN-LITVHKL 1117
            ..::..::  |:..::.:....|.:| |:.::|:
  Fly  1250 HYIKERTKNAQFIIVSLRVNMFELANFLVGIYKV 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	38/170 (22%)
		SMC_prok_B	115..1076	CDD:274008	231/1223 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	23/94 (24%)
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	238/1269 (19%)