Protein Alignment SMC6 and SMC5

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1119
• Identity: 241/1119 - (21%)
• Similarity: 466/1119 - (41%)
• Gaps: 242/1119 - (21%)

  Fly    97 GKVISMRLTNFMCHSNLFIEFGPN--INFLVGNNGSGKSAVITALALGLTSSARATNRASSIQKL 159
            |::.|:...:|:.:|.  |.|.|.  :|.|.|.||||||.:::|:.|||.......:|::|:...
  Fly    14 GRIHSVYCKDFVSYSE--ITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76

  Fly   160 IKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQIRHSS--STYDLQDARGKSVSKKVSDIRR 222
            |::.:.||||.:.:  .|..|...:.|       |:|.:|:  ||:.:.|   |..|||  :...
  Fly    77 IQSNKTSATIIVRV--YGRTPNTTETF-------RRIINSNGLSTFSVND---KDTSKK--NFLA 127

  Fly   223 MLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSL-TECHALRR------ 280
            .:..|.|.|.|....|.|:..::|.|     .|.:.|:..|...||...| ...::|::
  Fly   128 AVSSFNIQVSNLCQFLPQDRVQDFSK-----MNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQA 187

  Fly   281 --HFTQELEQLE-KKKEMMIKHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELNNL 342
              |..:|.|:.: .||:..::|:   :..:|..:::|.||:.||....|..|:...:.:.:...:
  Fly   188 NVHANREKEKSDLVKKQKRLEHL---QMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEM 249

  Fly   343 EHSIKLIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLL 407
            :..:|   |.|...::..::.:....:..|..||.|:.:..:|...:..:..:  |:||..|..:
  Fly   250 KTQVK---NAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAV--AEKAAIDGKM 309

  Fly   408 EASQ--VKAKIGNAERRMREDQRSYDECE---KLIGNYHADFNRVNEQREENANKIEMLKKQVVK 467
            ::.:  :..|....|:.:::.:|:..||:   :|:.|...:...:|:.|....:::|..|:....
  Fly   310 DSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAA 374

  Fly   468 S-----EEIIAQLRAEQQ---EIKRDITSVQERLDAVKNGRIQ----LHKSKQNISWEIEALSRN 520
            :     |:...:.:.||:   |:..:||:.:.:::.::|.::|    :.....|:...:..|::|
  Fly   375 ARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQN 439

  Fly   521 KSN-KLSVYG----EQTIQ---------VVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLI 571
            |.. ||:||.    |.|:|         .|.|.|..:|              :.........|||
  Fly   440 KQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFA--------------FACEDKGDMSDLI 490

  Fly   572 ENQLMHCLRSFIVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQPTTPNTTVL 636
             |:|  |:          :|.|         |.|:  |..:|....||       .|.||
  Fly   491 -NEL--CV----------KQKL---------GVNV--IYCAPSDRLVY-------SPKTP----- 519

  Fly   637 IDEISCDDPVVMNYLIDILRIETVLVTESKEIAEFLTSDTENVP------PNLTRVLVPNLGLEY 695
            ||::....  ..:||:|::.....|:  :|..|.:   ...|:|      .|.|..:...:.:.:
  Fly   520 IDDLRSFG--FRSYLVDLVTGPIPLI--NKLCASY---SIHNIPIGTEAVGNYTSSIPKAIRVYF 577

  Fly   696 IPSPNYAVYSTR------ITPARYIQKN----VDDRIRQLQMEQ-SDLQEKEPSLEIDYMQHKKV 749
            ..|..:.|.::|      :|.:....||    ||.:...|.|:| |:..::..|::....|....
  Fly   578 GGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNE 642

  Fly   750 LENTQKV----------ISQKSTMIGQHQSRNQKAMQKIMELQNFD-------------YQELPE 791
            .|..|.|          :.||.......::..:...:|:..|:|.|             :::|.:
  Fly   643 FERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHKDLKK 707

  Fly   792 YDRLKSHLADSGEKIEKCRLEREMLQEK--LLSIQHRQTELES---TEAEERRALEGINKKLTAL 851
            .....:.|....:.|::..:|:.|.|.|  :..:|| :|::|:   :|.:.:.|.....:.|..|
  Fly   708 IFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQH-ETQIEALKESEEQSKAATRDFQQLLQCL 771

  Fly   852 DTEAGEVESKMRSLD--LHYEENTRR---FQKTLQLERKMLGEKETV-LSELEKARTEAEKLGEF 910
            :.:..:|..:..::.  .|.|..|..   |:|..:       |.|.: |.||.:|      :.:|
  Fly   772 ENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFR-------ELENIDLPELREA------IHDF 823

  Fly   911 IATTQTEEKIR-EAISRY---KSKIKQVEE-----LNYNPEELERGLAELRDELELQSRHLAVVD 966
            .|..:..:.:. ||||.|   ::::||:||     :| ..:.:|.|::.|.|:.|.:...|  |:
  Fly   824 QARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVN-QAKSIESGMSNLYDKWEPKLNSL--VE 885

  Fly   967 SVVKKL-----RMAYHQRAQLFQRSRH---HYFTMVQFQFEQALAMRQFKVSFETSDKEKTWKIN 1023
            ::..|.     .:.|.....|.:..::   .|...:..||.:.|.::......:
  Fly   886 TISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDKFIQ----------- 939

  Fly  1024 VFPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILIGEG 1088
                           |||||:.:.......|...:..||..:||.:...|..|.:.|.::|:.|.
  Fly   940 ---------------SGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEA 989

  Fly  1089 LEWLSRQYCFLTPQ 1102
            .:..|.||.|:||:
  Fly   990 TKHGSAQYLFVTPK 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	46/152 (30%)
		SMC_prok_B	115..1076	CDD:274008	227/1073 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	21/76 (28%)
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	49/166 (30%)
		SMC_N	22..>425	CDD:481474	98/431 (23%)
		SMC_prok_B	<193..1001	CDD:274008	183/915 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	24/111 (22%)