Protein Alignment SMC6 and smc3

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_999854.1
• Gene: smc3 / 324475
• ZFINID: ZDB-GENE-030131-3196
• Length: 1216
• Species: Danio rerio
• Alignment Length: 1226
• Identity: 238/1226 - (19%)
• Similarity: 450/1226 - (36%)
• Gaps: 344/1226 - (28%)

  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLT---SSARATNRASSIQKLIKNGEVSATISITLSNSGL 178
            ||...|.:||.||||||....|:...|:   |..|...|.:.:.:......:||.:.|...||..
Zfish    23 FGSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDN 87

  Fly   179 R-PFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIRRMLLCFGINVENPIFVLNQEA 242
            | |...:    .:::.|.|......|.|..   |.|:|  :|:..:|...|.:..||.:::.|..
Zfish    88 RLPIDKE----EVSLRRVIGAKKDQYFLDK---KMVTK--NDVMNLLESAGFSRSNPYYIVKQGK 143

  Fly   243 AREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQLEKKKEMMIKHIAAEEEKL 307
            ..: :.....:...|||.:.....|......|..:|.:    |.|...:|...::|:|   ||:|
Zfish   144 INQ-MATAPDSQRLKLLREVAGTRVYDERKEESISLMK----ETEGKREKINELLKYI---EERL 200

  Fly   308 SILEDKEMVKENLQQCKTKLAW------MAVTSYQNELNNLEHSIKLIENKKASLEQTTSKKES- 365
            ..|||:   ||.|.|.:   .|      :..|.|..|||          ..:|.|::.:||:|:
Zfish   201 HTLEDE---KEELAQYQ---KWDKMRRALEYTIYNQELN----------ETRAKLDELSSKRETC 249

  Fly   366 ---------TQATMNQKLKEFEASKNQI---LATQKFQDERLKTAK----KAVQDLLLEASQVKA 414
                     .|.....|::|.|....::   ::..|.:.|:|...:    |....|.|:|..::.
Zfish   250 GDKSRQLRDAQQDARDKVEETERVVRELKSRISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQD 314

  Fly   415 KI-GNAERR---MREDQR---SYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKSEEII 472
            :: ||:|:|   ::|.|:   ..:|.:|.:......||.|.|:.|....::....::  :::...
Zfish   315 ELAGNSEQRKRLLKERQKLLEKIEEKQKELQETEPKFNTVKEKEERGIARLAQATQE--RTDLYA 377

  Fly   473 AQLRAEQ--------QEIKRDITSVQERLDAVKNGRIQLHKSKQNISWEIEALSRNKSNKLSVYG 529
            .|.|..|        :.||:::.|:.:.::..|.....:||       ::|...:||...|..|.
Zfish   378 KQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHK-------DLEDTEQNKERNLEQYN 435

  Fly   530 EQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPK----------YRDLIENQLMHCLRSFIV 584
            :.. |.::.::|:     :..:.:    :|....|.|          :|:  ||.....|.:...
Zfish   436 KLD-QDLNEVKTR-----VEELDK----KYYEVKNRKDELQSERNYLWRE--ENAEQQALAAKRE 488

  Fly   585 GSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNK-VQPTTPN--TTVLIDEISCDDPV 646
            ..::::|.|||........|     |.|  .::|.:..|.| :.....|  ..::::...|:...
Zfish   489 DLEKKQQLLRAATGKAILNG-----IDS--INKVLEHFRRKGINQHVINGYHGIVMNNFECEPAF 546

  Fly   647 -----------VMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLE--YIPS 698
                       :..::::...:.|.::.|..::         |:|..:|.:.:..|.:.  ..|.
Zfish   547 YTCVEVTAGTRLFYHIVETDEVSTKILMEFNKM---------NLPGEVTFLPLSKLDVRDTAYPE 602

  Fly   699 PNYAVYSTRITPARYIQ------KNV--------------------------------------- 718
            .|.|:  ..|:..||.|      |:|
Zfish   603 TNDAI--PMISKLRYSQNFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALT 665

  Fly   719 ----DDRIRQLQMEQSDLQEKEPSL--------------------EIDYM---------QHKKVL 750
                |.|..:|:: |.|:::.|..|                    |||.:         |.:|..
Zfish   666 GGYYDTRKSRLEL-QKDMRKAEEELGELEAKLNENLRRNIETINNEIDQLMNQMQQIETQQRKFK 729

  Fly   751 ENTQKVISQKSTMIGQHQSRNQKAMQKIMELQNFD---YQELPEYDRLKSHLA------------ 800
            .:...::|:...:..:.|...:..|.|...||:.:   :......:.||:.|.
Zfish   730 ASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGADLLSQLSLEDQ 794

  Fly   801 ----DSGEKI------------EKCRLE----------REMLQEKLLSIQHRQTELESTE----- 834
                |..::|            |:.:||          .|.|:::|..::....||..||
Zfish   795 RRVDDLNDEIRQLQQDNRQLLNERIKLEGIMTRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859

  Fly   835 AEERRALEGINKKL-----------TALDTEAGEVESKMRSLD----LHYEENTRRFQKTLQLER 884
            ......|:||||::           |.:|....|::...:|::    :..|:|......|.:||
Zfish   860 TATTSELDGINKRIKDTMARSEDLDTLIDKTEVEIKEHQKSMERWKNIEKEQNEAINHDTKELE- 923

  Fly   885 KMLGEKETVLSELEKARTEAEKLGEF-------------------IATTQTEEK-----IREAIS 925
            ||...:..:|.:.|:...:..:||..                   :....||.|     .::|:.
Zfish   924 KMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLTLKQLFRKLEQCNTELKKYSHVNKKALD 988

  Fly   926 RYKSKIKQVEELNYNPEELERG---LAELRDELELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSR 987
            ::.:..:|.|:|....:||:||   :.||.:.|||:.         .:.:::.:.|.::.|.
Zfish   989 QFVNFSEQKEKLIKRQDELDRGYKSIMELMNVLELRK---------YEAIQLTFKQVSKNFS--- 1041

  Fly   988 HHYFTMVQFQFEQALAMR-------QFKVSFETSDKEKTWKINVFPPS----------------G 1029
             ..|..:....:..|.|:       |.:...|..|.|:........||                .
Zfish  1042 -EVFQKLVPGGKATLVMKKGDTEGGQSQDEGEGGDSERASSSQSSVPSVDQFTGVGIRVSFTGKQ 1105

  Fly  1030 NETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILI 1085
            .|....:.||||::|...::|:..:......|||..||.|...|..:||..:::::
Zfish  1106 GEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAASDMIM 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	36/134 (27%)
		SMC_prok_B	115..1076	CDD:274008	236/1215 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	18/75 (24%)
smc3	NP_999854.1	SMC_N	2..1196	CDD:481474	238/1226 (19%)