Protein Alignment SMC6 and Smc6

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_001101484.1
• Gene: Smc6 / 313961
• RGDID: 1311214
• Length: 1097
• Species: Rattus norvegicus
• Alignment Length: 1150
• Identity: 308/1150 - (26%)
• Similarity: 555/1150 - (48%)
• Gaps: 143/1150 - (12%)

  Fly    29 KRSKQQFVAEAEPDFVEEE-TEKYANASTSQTARSRNKQARQTTLNMSQRSVNFNLTSELSIPNA 92
            ||.:|:.:.:.:.|..|:| |..:.|.:::.||                        :|:.|
  Rat    16 KRPRQEELEDFDKDGDEDECTISFTNGTSTLTA------------------------AEVGI--- 53

  Fly    93 FDRCGKVISMRLTNFMCHSNLF-IEFGPNINFLVGNNGSGKSAVITALALGLTSSARATNRASSI 156
                  :.|::|.||||||.|. .:||.|:||:|||||||||||:|||.:||...|.||||.||:
  Rat    54 ------IESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSL 112

  Fly   157 QKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQIR-HSSSTYDLQDARGKSVSKKVSDI 220
            :..:|.|:.||.|||||.|.|...|:|:::|..:.|.:.|. ..|.:|.|:..:|..||.:..::
  Rat   113 KGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEEL 177

  Fly   221 RRMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQE 285
            ..:|..|.|.|:||:.||.||.:::||:.......||..||||||:......:.....:....::
  Rat   178 IAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQ 242

  Fly   286 LEQLEKKKEMMIKHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIE 350
            :.|.|::...:.:....:||:...:.....:|.||:..|.::||..|...:.:||.:..:||:.|
  Rat   243 INQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGE 307

  Fly   351 NKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLLEASQVKAK 415
            .:.|.|::   |.|..|..:|...|:::..::::   :|..:|   |..:|.:.:.|:...:..
  Rat   308 ERAAKLDR---KMEEQQVRLNDAEKKYKDIQDKL---EKISEE---TNARAPECMALKTDVIAR- 362

  Fly   416 IGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKS------------ 468
                       .|::::.|.|......::..:.:..|:...:||.|||...:|
  Rat   363 -----------TRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRI 416

  Fly   469 ---EEIIAQLRAEQQEIKRDITSVQERLDAVKNGRIQLHKS----KQNISW---EIEALSRNKSN 523
               :|.:..|:.::..:.:::...::.::..|...:::.:.    :..:|:   :::.|..:|::
  Rat   417 CWLKEKVKALQDQENTVNQEVEQFEQAIEKDKQEHVRIKREDVEVRHTLSYNQRQLKELKDSKTD 481

  Fly   524 KLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIENQLMHCLRSFIVGSDR 588
            :|..:|.....::.|:...|........|.||||..|...:|:....||:.|...|:::...:..
  Rat   482 RLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHA 546

  Fly   589 ERQSLRALLQNKF--QGGNMPTIITSPFTDRVYDVS-RNKVQPTTPNTTVLIDEISCDDPVVMNY 650
            :.:.|::|:: ||  .|.:.|.||.|.|.:.||||. |....|..|  ||| ..:..|:.||.|.
  Rat   547 DERVLQSLMK-KFYPPGTSRPQIIVSEFRNEVYDVRLRAAYHPEFP--TVL-TALEIDNAVVANS 607

  Fly   651 LIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLEYIPSPNYAVYSTRITPARYIQ 715
            |||:..|||||:.::..:|..:....:  ||...|......|.:......|:..|||   .:::.
  Rat   608 LIDMRSIETVLLIKNNSVARAVMQSQK--PPKNCREAFTADGDQVFAGRYYSSESTR---PKFLS 667

  Fly   716 KNVDDRIRQLQMEQS-------DLQEKEPSLEIDYMQHKKVLENTQ---KVISQKSTMIGQHQSR 770
            ::||..|..|:.|..       :||.:..:||.|..:::::|:..|   |.|..|.
  Rat   668 RDVDSEISDLETEIENKKGHIMNLQHRLSALEKDIKRNEELLKRCQLHYKEIKMKI--------- 723

  Fly   771 NQKAMQKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCRLEREMLQEKLLSIQHRQTELESTEA 835
             :|.:.:|.||:|.:..:..:...|:....::  ||:...:|:.|.|:|     .....|::.:.
  Rat   724 -RKNISEIRELENIEEHQSVDIATLEDEAEEN--KIKMQMVEKNMEQQK-----ENMENLKTLKI 780

  Fly   836 EERRALEGINKKLTALDTEA-----------GEVESKMRSLDLHYEENTRRFQKTLQLERKMLGE 889
            |.....:.|..|:..|...|           .||:|:.|... |||:..:....||..:|:.|..
  Rat   781 EAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQ-HYEDKQKEHMDTLNKKRRELDM 844

  Fly   890 KETVLSELEKARTEAEKL-GEFIATTQTEEKIREAISRYKSKIKQVEELNYNPEELERGLAELRD 953
            ||   .||::..::|.:: .|.|...::...:.:.|:|.:.||:.....:.:.||:.:...|.|:
  Rat   845 KE---KELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARE 906

  Fly   954 E-LELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHYFTMVQFQFEQALAMRQF--KVSFETSD 1015
            . |:|.|: :..:...:|.|......|.:.:|:.|.......:..|:..|:.|.:  |::|:  .
  Rat   907 TYLDLDSK-VRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFD--H 968

  Fly  1016 KEKTWKINVFPPSGNETS--NTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRK 1078
            |.:|..|:|.|..||:.|  :.|:||||||||:||..:..|||.::.||..|||:||:.|.|||:
  Rat   969 KNETLSISVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRR 1033

  Fly  1079 FITEILIGEGLEWLSRQYCFLTPQD-TKVEASNLITVHKLEAPER 1122
            ...::::........||:..||||. :.:.:|.||.:.::..|||
  Rat  1034 IAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPER 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	70/150 (47%)
		SMC_prok_B	115..1076	CDD:274008	272/1013 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	38/97 (39%)
Smc6	NP_001101484.1	P-loop containing Nucleoside Triphosphate Hydrolases	54..>210	CDD:476819	71/155 (46%)
		SMC_prok_B	<221..1055	CDD:274008	209/887 (24%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<983..1081	CDD:476819	38/95 (40%)