Protein Alignment SMC6 and Smc5

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_001425107.1
• Gene: Smc5 / 293967
• RGDID: 1307492
• Length: 1102
• Species: Rattus norvegicus
• Alignment Length: 1222
• Identity: 257/1222 - (21%)
• Similarity: 464/1222 - (37%)
• Gaps: 294/1222 - (24%)

  Fly    54 ASTSQTARSRNKQA------RQTTLNMSQRSVNFNLTSELSIPNAFDRCGKVISMRLTNFMCHSN 112
            |:.|..|.:.|.||      |..:.....:..|.|.||.|..|:.....|.::.:.:.||:.:..
  Rat     2 ATPSGKAAAPNPQASKRSLPRDASSEFPSKRKNSNPTSTLPRPSGLFVEGSIVRIAMENFLTYDI 66

  Fly   113 LFIEFGPNINFLVGNNGSGKSAVITALALGLTSSARATNRASSIQKLIKNGEVSATISITL-SNS 176
            ..:..||::|.::|.||:|||:::.|:.|||........||..:...:|.|.....:.|.| ..|
  Rat    67 CEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSKGLVEIELFRTS 131

  Fly   177 GLRPFKADIFGPHLTVVRQ---IRHSSSTYDLQDARGKSVSKKVSDIRRMLLCFGINVENPIFVL 238
            |           :|.:.|:   |::.|..:    ...|.|::|:  :...:....|.|.|....|
  Rat   132 G-----------NLIITREIDVIKNQSFWF----INKKPVTQKI--VEEQVAALNIQVGNLCQFL 179

  Fly   239 NQEAAREF--LKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQLE----KKKEMMI 297
            .|:...||  |.::|       |::||:..:....:...|...::|.::.:|||    :|.|.:.
  Rat   180 PQDKVGEFAKLSKIE-------LLEATEKSIGPPEMHRYHCELKNFREKEKQLETSCKEKTEYLD 237

  Fly   298 KHIAAEEEKLSILE---DKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIENKKASLEQT 359
            |.|...|.....:|   :::...:.::..:.|..|:   .|:|.....| .:||:.::   :::.
  Rat   238 KMIQRNERYKQDVERFYERKRHLDLIEMLEAKRPWV---EYENVRQEYE-GVKLVRDR---VKEE 295

  Fly   360 TSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLLEASQVKAKIGNAERRMR 424
            ..|.:..|..|.::::|.|..:..:       :.|:|.....:::...:..|.:..|...:|.::
  Rat   296 VRKLKEGQIPMTRRIEEIERQRRTL-------EVRIKEKATDIKEASQKCKQRQDLIERKDRHIK 353

  Fly   425 EDQRSYDECEKLIGNYHADFNRVNEQREENANK-IEMLKKQVVKSEEIIAQLRAEQQEIKRDITS 488
            |.|::....:    |...|    .::|..|..| ||.|:.: :::.|....|:.:...|..|:..
  Rat   354 ELQQALTVKQ----NEEQD----RQKRISNTRKMIEDLQNE-LRTAENCENLQPQIDAITNDLRR 409

  Fly   489 VQERLDAVKNGRI--------QLHKSKQNISWEI---EALSRNKSNKLSVYGEQTIQVVHALRTQ 542
            |||. .|:..|.|        .|.|.|:::|..|   :.|...|.:||......|...|..||
  Rat   410 VQEE-KALCEGEIIDKQREKEMLEKQKRSVSDHITRFDNLMNQKEDKLRQRYRDTYDAVLWLR-- 471

  Fly   543 YAGSNMHRMPR---GPLGQYISAPNPKYRDLIENQL-MHCLRSFIVGSDRERQ-SLRALLQNKFQ 602
               :|..|..:   .|:...|:..:.|....:||.: .:.||:|:..|..:.: .||.:..||..
  Rat   472 ---NNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSNDLRAFVFESQEDMEIFLREVRDNKKL 533

  Fly   603 GGNMPTIITSPFTDRVYDVSRNKVQPTTPNTTVLIDEISCDDPVVMNYL---------------- 651
            ..|........:.|:....|.|::: .....:.|.:.....|| ||:||
  Rat   534 RVNAVIAPKISYADKAPSRSLNELK-QYGFFSYLRELFDAPDP-VMSYLCCQYHIHEVPVGTERT 596

  Fly   652 -------IDILRIETVLVTESK-------------------EIAEFLT-----SDTENVPPNLTR 685
                   |...|::.:...|.|                   ::|:|||     ....::...|..
  Rat   597 RERIERVIQETRLKQIYTAEEKYVLKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKE 661

  Fly   686 VLVPNLGLEYIPSPNYAVYST--------------------RITPARYIQKNVDDR---IRQLQM 727
            :   |..||.:.|...|:..|                    |.|..|.:::.:..:   ||.::.
  Rat   662 I---NRKLEAVDSGLVALRDTNRHLELKDNELRLKKKELLERKTKKRQLEQKISSKLASIRLMEQ 723

  Fly   728 EQSDLQEKEPSL-----EIDYMQHKKVLENT-----------QKV--ISQKSTMIGQHQSRNQKA 774
            :..:|:|:|...     ||:..:.|.|.|.|           |||  |.|.:|:|.:........
  Rat   724 DTCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSLHIQKVDLILQNTTVISEKNKLEADY 788

  Fly   775 MQKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCR-LEREMLQEKLLSI-----QHRQTELEST 833
            |....:|:..: |:..|.|..:..|      ::||: |.:...|...||.     |..||::.:.
  Rat   789 MASSSQLRVTE-QQFIELDDNRQRL------LQKCKELMKRARQVCNLSADQAVPQEFQTQVPTI 846

  Fly   834 ----EAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVL 894
                .:....|.:.:...|..:|.             |..||.:|....|        |...:|:
  Rat   847 PNGHSSSPPMAFQDLPNTLDEIDA-------------LLTEERSRASCFT--------GLNPSVV 890

  Fly   895 SELEKARTEAEKLGEFIATTQTEEKIREAISRYKSKIKQVEELNYNP-EELERGLAE-------- 950
            .|..|...|.::|.|.:...:.|      :..|:..|.||:|...|| :||...:.|
  Rat   891 EEYTKREIEIQQLTEELKGKKVE------LDEYRENISQVKERWLNPLKELVEKINEKFSNFFSS 949

  Fly   951 --LRDELELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHYFTMVQFQFEQALAMRQFKVSFET 1013
              ...|::|.:.:....|....::|:.:....||.:.:.||.
  Rat   950 MQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQ----------------------- 991

  Fly  1014 SDKEKTWKINVFPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRK 1078
                                     ||||||.:|:..|..|...:..||..:||.:...|.:|.:
  Rat   992 -------------------------SGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINER 1031

  Fly  1079 FITEILIGEGLEWLSRQYCFLTPQDTK-VEASNLITV-------HKLEAPER 1122
            .:.|:::....:..:.||.|:||:..: :..|..:||       |.|| |.|
  Rat  1032 RVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLE-PNR 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	37/154 (24%)
		SMC_prok_B	115..1076	CDD:274008	226/1099 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	28/102 (27%)
Smc5	NP_001425107.1	None