Protein Alignment SMC6 and Smc1a

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_062684.2
• Gene: Smc1a / 24061
• MGIID: 1344345
• Length: 1233
• Species: Mus musculus
• Alignment Length: 1283
• Identity: 267/1283 - (20%)
• Similarity: 480/1283 - (37%)
• Gaps: 344/1283 - (26%)

  Fly   102 MRLTNFMCHSNLFIEFGPNINF--LVGNNGSGKSAVITALALGLTSSARATN-RASSIQKLIKNG 163
            :.:.||..:....| .||...|  ::|.||||||.::.|::..|  ..:.:| |..:::.||...
Mouse     7 IEIENFKSYKGRQI-IGPFQRFTAIIGPNGSGKSNLMDAISFVL--GEKTSNLRVKTLRDLIHGA 68

  Fly   164 EVS------ATISITLSNSGLRPFKADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKVSDIR- 221
            .|.      |.:|:..|..|         ....|..|.|...||.|        .::.||..:.
Mouse    69 PVGKPAANRAFVSMVYSEEG---------AEDRTFARVIVGGSSEY--------KINNKVVQLHE 116

  Fly   222 --------------RMLLCFGINVENPIFVLNQEAAREFLKEL----EPASNY----KLLMKA-- 262
                          |..|.|...||: |.:.|.:......:|:    |.|..|    |.::||
Mouse   117 YSEELEKLGILIKARNFLVFQGAVES-IAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE 180

  Fly   263 -TQLDVCTSSLTECHALRRHFTQELEQLEK----KKEMM----------IKHIAAEEEKLS---- 308
             ||.:.....  ...|.|:...||.|:.::    |.|::          :.|...|.|||:
Mouse   181 DTQFNYHRKK--NIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELA 243

  Fly   309 -----ILEDK---EMVKENLQQCKTKLAWM---------AVTSYQNELN-----------NLEHS 345
                 |.:||   :.|::.|::.|.:|..|         .:....:|||           |..|.
Mouse   244 SKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHK 308

  Fly   346 IKLIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDLLLEAS 410
            ||.:|..|.||:......:..:..|::..||..:.:.   |.|:|::...:.::...:||.||.:
Mouse   309 IKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEK---ARQEFEERMEEESQSQGRDLTLEEN 370

  Fly   411 QVKAKIGNAERRMREDQRSYDECEKLIGNYHADFNRVN-EQR----------------EENANKI 458
            |||......|...:.......|.||...:..||.:|:: |:|                |||..:|
Mouse   371 QVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRI 435

  Fly   459 EMLKKQVVKSEEIIAQLRAEQQEIKRDITSVQERLDAVKNGRIQLHKSKQNISWEI--EALSRNK 521
            |.|::.:..|::.:.:.:..:.|:..::...:.|:|       :::|....:..::  ..:.|.:
Mouse   436 EKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRID-------EINKELNQVMEQLGDARIDRQE 493

  Fly   522 SNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNP---KYRDLIENQLMHCLRSFI 583
            |::    .::..:::.:::..|.||        ..|:.|....|   ||:..:...|...:.:.|
Mouse   494 SSR----QQRKAEIMESIKRLYPGS--------VYGRLIDLCQPTQKKYQIAVTKVLGKNMDAII 546

  Fly   584 VGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQPT------TPNTTVLIDEI-- 640
            |  |.|:.....:...|.|.|...|.:...:.:         |:||      .....::||.|
Mouse   547 V--DSEKTGRDCIQYIKEQRGEPETFLPLDYLE---------VKPTDEKLRELKGAKLVIDVIRY 600

  Fly   641 -----------SCDDPVVMNYLIDILRI--------ETV-------------------------- 660
                       :|.:.:|.:.:.|..||        :||
Mouse   601 EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARR 665

  Fly   661 ----LVTESKEIAEFLTSD------TENVPPNLTRVLVPNLGLEYIPSPNYAVYSTRITPARYIQ 715
                .|.:.||..|.||.:      .:.....|.:|.....||:.  ...|:......|..|::.
Mouse   666 WDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQM--RLKYSQSDLEQTKTRHLA 728

  Fly   716 KNVDDR--------------------IRQLQMEQSDLQEKEPSLEIDYMQH-------KKVLE-N 752
            .|:.::                    |:..:.|..||:||...:|.:..:.       :.:.| .
Mouse   729 LNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFE 793

  Fly   753 TQKVISQKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKSHLADSGEK-----IEKCRLE 812
            .:||..|......:.:..|||....|.  .:|:..:|.| |:.|.|:.:...|     |||.:.|
Mouse   794 EEKVKRQNEIAKKRLEFENQKTRLGIQ--LDFEKNQLKE-DQDKVHMWEQTVKKDENEIEKLKKE 855

  Fly   813 RE---------MLQEKLLSIQH--RQTEL--ESTEAEE-RRALEGINKKLTALDTEAGEVES--- 860
            .:         |.|.:.|..||  :::|:  ::.|.|| |:.|.|.||::|.|..|...:|:
Mouse   856 EQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLE 920

  Fly   861 -------------KMRSLDLHYEENT----RRFQKTLQLERKMLGEKETVLSELEKARTEAE--K 906
                         ||:.:.|...:.|    .:.:.:.|.|..:.|.:.|......:|..|.:  .
Mouse   921 QKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEESVSGSQRTSSIYAREALIEIDYGD 985

  Fly   907 LGEFIATTQTEEKIREAISRYKSKIKQVEELNY-----NPEELERGLAELRDELELQSRHLAVVD 966
            |.|.:...|.||:|::.::..:.|:.:.:.:..     |.:.:|: |..:||:.:..|.......
Mouse   986 LCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEK-LESVRDKFQETSDEFEAAR 1049

  Fly   967 SVVKKLRMAYHQ-RAQLFQRSRHHYFTMVQFQFEQ---ALAMRQFKVSF---ETSDKEKTWKINV 1024
            ...||.:.|:.| :.:.|.|. :..|..|....::   ||:......:|   |..::.....||.
Mouse  1050 KRAKKAKQAFEQIKKERFDRF-NACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINY 1113

  Fly  1025 --------FPPSGNETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFIT 1081
                    |.|..|       |||||::...::||..:.|....||:.|||.|...|..|
Mouse  1114 NCVAPGKRFRPMDN-------LSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTN----- 1166

  Fly  1082 EILIGEGLEWLSRQ-------YCFLTPQDTKVEASNLITVHKLEAPER 1122
               ||:...::..|       ......::...:|.:||.|:    ||:
Mouse  1167 ---IGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVY----PEQ 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	39/169 (23%)
		SMC_prok_B	115..1076	CDD:274008	255/1215 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	26/101 (26%)
Smc1a	NP_062684.2	SMC_N	3..1210	CDD:426784	267/1283 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..308		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..369		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..969		3/21 (14%)