Protein Alignment SMC6 and dpy-27

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_497771.1
• Gene: dpy-27 / 175492
• WormBaseID: WBGene00001086
• Length: 1469
• Species: Caenorhabditis elegans
• Alignment Length: 1315
• Identity: 251/1315 - (19%)
• Similarity: 487/1315 - (37%)
• Gaps: 377/1315 - (28%)

  Fly    99 VISMRLTNFMCHSNLFIEFGP---NINFLVGNNGSGKSAVITAL--ALGLTSSARATNRASSIQK 158
            ::::.:.||..::...| .||   |:..::|.||||||.||.||  ..|..:....|.:.|:
 Worm    93 ILNIYVENFKSYAGKHI-LGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSA--- 153

  Fly   159 LIKNGEVSATISITLSNSGLRPFKADIFGPH-------LTVVRQI-RHSSSTYDLQDARGKSVSK 215
            ||.:|....:.|:|:....::....:.:..:       :.:.|.| |.::|.|.:.|   |..|:
 Worm   154 LINSGGNYESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYRIDD---KDASQ 215

  Fly   216 KVSDIRRMLLCFGINVENPIFVL------------------NQEAAREFLKELEPASNY-----K 257
            |  |::.:||..||::.:..|::                  |:|...|:::::...:.:     |
 Worm   216 K--DVQELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISK 278

  Fly   258 LLMKATQLDVCTSSLTECHALRRH----------------FTQELEQLEKKKEMMIKH------I 300
            |:.:.:.|:..:|....  ::|||                :......|...:.:.:||      .
 Worm   279 LMHRVSLLEHKSSQYGA--SVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRVKHNLCRYAE 341

  Fly   301 AAEEEKLSIL-------EDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSIKLIENKKASLEQ 358
            ...:.|:|::       |:|:::.|...:.:.|      .:::..||::   :..:|||:...:.
 Worm   342 TMRDAKMSLVTRTGELEENKDIMLEAKDEVRKK------ETHERSLNSI---VTELENKRIDWQS 397

  Fly   359 TTSKKESTQATMNQKLKEFEASKNQIL------ATQKFQDERL-KTAKKAVQDLLLEASQVKAKI 416
            ..:...:..|...|.||.......:::      ..:||:.|.. :.|:.:.|::.||..|:|.:.
 Worm   398 KKNDWHARDAKRKQGLKSCTQDLGKLMKERDEARREKFEIETAPENARISKQNMQLEWDQLKEQE 462

  Fly   417 GNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANKIEMLKKQVVKSEEIIAQLRAEQQE 481
            ...:|...|:...||:             :.:..|.::.:..:.|..::::|....|:|...:.|
 Worm   463 NVCQRTATENLIKYDQ-------------KSSADRAKHDDLEKKLSDELLQSMRAKAELDVSESE 514

  Fly   482 IKRDITSV----QERLDAVKNGRIQ-------------------LHKSKQNISWEIEALSRNKSN 523
            :| |:|.:    |:|:|.:| |.:|                   |...|......:|.|...||.
 Worm   515 LK-DMTIMMEQGQKRVDELK-GTLQTMMAENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKST 577

  Fly   524 KLSVYGEQTI---------QVVHALRTQ------YAGSNMHRMP--------RGPLGQYISAPNP 565
                  ||.:         :|:.|..||      .|.:.:|.:.        :|.||...|.| .
 Worm   578 ------EQLLRSKKYELDQEVIEASNTQEVTYRHQATAKLHELKEAGLFPGFKGRLGDLASIP-I 635

  Fly   566 KYRDLIENQLMHCLRSFIV-GSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQPT 629
            |:...|.......|...:| .||..|..:....:.|     :|. .|..|.|.:.|...:.:..|
 Worm   636 KFDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEYK-----LPR-TTFVFLDHLKDTDTSGMDST 694

  Fly   630 TP-NTTVLIDEISCDDPVVMN--YLIDILRIETVLVTESKEIA-----------EFLTSD----- 675
            .. ....|.|:|.|.:|.:..  |.:    |..:||.:|.|.|           .:.|.:
 Worm   695 MKFPAERLFDKIHCVNPEIRREFYFL----IHDILVVDSLEEATRIDKKYPGRHRYCTLNGSILN 755

  Fly   676 -----TENVPPNLTRVLVPNLGLEYIPSPNYA-VYSTRITPARYIQ------------------- 715
                 |....|...|:...|       :||.: |....::..|..|
 Worm   756 RSGALTGGGKPTTGRIRNDN-------NPNMSGVKKVDLSKLRAAQEKHNHALEAHLKLQLKQEE 813

  Fly   716 ---------KNVDDRIRQLQMEQSDLQEKEPSLEIDYMQHKKVLENTQKV----ISQKSTMIG-- 765
                     |.::.|.|:|.|...:.:.:...|:.....|::.:.|.::|    :.:|...|.
 Worm   814 IRADNGPIIKQLEIRKRELIMSTKEQKTRIAELKSSIAAHERRMVNYREVTVEDLDEKRAQIADL 878

  Fly   766 -QHQSRNQKAMQKIMELQNFDYQELPEY----DRLKSHLADSG-EKIEKCR-----LER------ 813
             :....:||:..||.       |::.:|    ||:...|.... :.||:.:     ||:
 Worm   879 KRQVEESQKSSAKIK-------QQIEQYKRKMDRMFMELVQKNKDSIEQAKDRMGQLEQDIARQT 936

  Fly   814 ----------EMLQEKLLSIQHRQTELESTEA---------EERRALEGINKKL----TALDTEA 855
                      |..::||..::|...|..| ||         |:.:.::.||.:|    .::|.:.
 Worm   937 AIIENNPSHLEQAEKKLSELEHMCLEKRS-EADALAQLEVGEDVKGIDIINAQLQTSTASIDAQR 1000

  Fly   856 G---EVESKMRSLDLHYEENTRRFQKTLQ-----------LERKMLGEKETVLSELEKARTEAEK 906
            .   |..:..|..|..|:.....:....|           ||.|.:.: ...|..:|.|..:.||
 Worm  1001 ARYTEAVAARREADAAYQTTVDNYNMVKQTYDELMRIIDDLENKTMAD-NAELDIIESAWMQPEK 1064

  Fly   907 L---GEF-------IATTQTE-------------EKIREAISRYKSKIKQ---VEELNYNPEELE 945
            |   |:|       ||...|:             |..|||...:::::.:   .|:......:||
 Worm  1065 LYPPGKFVRYNDPDIAAKMTDGHVVLPYECISMIEPHREAYEEHEARMLEDDVFEDTANKICKLE 1129

  Fly   946 RGLAELRDELELQS-RHLAVVDSVV-----------KKLRMAYHQRAQLFQRSRHHYF------- 991
            :.:.:.|.|.:.:. |..|::.|::           .||: |:.::....:.:|.:.|
 Worm  1130 KDVDKFRREFDNKGVRDYAMIVSLLMNEVTSAKKFSDKLK-AHREKLNELRMARFNEFSEALAFL 1193

  Fly   992 ---TMVQFQF------------EQALAMRQFK--VSFETSDKEKTWKINVFPPSGNETSNTRSLS 1039
               |.:.:|.            |:..:...|.  :.|.....:|:||:            ..:||
 Worm  1194 GTTTQMLYQLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKL------------IENLS 1246

  Fly  1040 GGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILIGEGLEWLSRQYCFLTPQDT 1104
            |||::..::..:..:......|.|.:||.|...|..|...|.. .|.......:.|:..::.::.
 Worm  1247 GGEKTLASLCFVFAMHHYRPTPLYVMDEIDAALDLNNVSLIAN-YIKHSERTRNAQFIIISLRNQ 1310

  Fly  1105 KVEASN-LITVHKLE 1118
            ..|..| |:.::|::
 Worm  1311 MFEVGNRLLGIYKID 1325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	43/179 (24%)
		SMC_prok_B	115..1076	CDD:274008	241/1254 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	19/93 (20%)
dpy-27	NP_497771.1	SMC_N	93..1328	CDD:481474	251/1315 (19%)