Protein Alignment SMC6 and Smc2

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_032043.3
• Gene: Smc2 / 14211
• MGIID: 106067
• Length: 1191
• Species: Mus musculus
• Alignment Length: 1212
• Identity: 235/1212 - (19%)
• Similarity: 461/1212 - (38%)
• Gaps: 347/1212 - (28%)

  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLTSSARATNRASSIQKLI-KNGE---VSATISITLSNSG 177
            |.|..|.:.|.||||||.::.::...|..|..:..|||::|.|: |||:   ..|::|||..||.
Mouse    23 FDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSD 87

  Fly   178 LRP----FKADIFGPHLTVVRQIRHSSSTYDLQDARGK----SVSKKVSDIRRMLLCFGINVENP 234
            .:.    |:|.   ..:||.||:        :...|.|    .|:...:.::.:....|:||.||
Mouse    88 KKQSPLGFEAH---DEITVTRQV--------VIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNP 141

  Fly   235 IFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQEL--EQLEKKKEMMI 297
            .|::.|....:.|.           ||..::   .|.:.|....|.:..:::  ::..:|||..:
Mouse   142 HFLIMQGRITKVLN-----------MKPPEI---LSMIEEAAGTRMYEYKKIAAQKTIEKKEAKL 192

  Fly   298 KHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEH------------------ 344
            |.|.      :|||  |.:...:|:.|.:.:  :...||..:..:||
Mouse   193 KEIK------TILE--EEITPTIQKLKEERS--SYLEYQKVMREIEHLSRLYIAYQFLRAEDTKE 247

  Fly   345 ----SIKLIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDERLKTAKKAVQDL 405
                .:|.:::|..:|::..|:.|.....:|.:::|.|..|          |:......|:::|.
Mouse   248 RSAGELKEMQDKIVNLQEVLSENEKKIKALNCEIEELERRK----------DKETGGKLKSLEDA 302

  Fly   406 LLEASQVKAKIGNA------------------ERRMREDQRSY----DECEKLIGNYHA------ 442
            ..||.:|..|..:|                  :..|.||.::.    .|.:|:....|.
Mouse   303 CAEAQRVNTKSQSAFDLKKKNLASEETKRKELQNSMAEDSKALAAKEKEVKKITDGLHGLQEASN 367

  Fly   443 -----------DFNRVNEQREENANKIEM------------LKKQVVKSEEIIAQLRAEQQEIKR 484
                       .||.|:.....|.:..|.            :.|...::::...:|:..|||:|.
Mouse   368 KDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMIACKNDISKAQTEAKQAQMKLKHAQQELKS 432

  Fly   485 DITSV----------QERLDAVKNGRIQLHKSKQNISWEIEALSRNKSNKLSVYGEQTIQVVHAL 539
            ....|          |:..:|||..:.:|....:.:::|     .||..||.....|..:.::.|
Mouse   433 KQAEVKKMDSGYKKDQDAFEAVKKAKEKLETEMKKLNYE-----ENKEEKLLEKHRQLSRDINNL 492

  Fly   540 RTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIENQLMHCLRSFIVGSDRERQSLRALLQN--KFQ 602
            :    |.:...:.:.|..|:      .|:|..:|.              .|.|::.|:.:  ..:
Mouse   493 K----GKHEALLAKFPNLQF------AYKDPEKNW--------------NRNSVKGLVASLINVK 533

  Fly   603 GGNMPTIITSPFTDRVYDV----------SRNKVQPTTPNTTVLIDEIS--CDDP----VVMNYL 651
            ..:..|.:.....:|:|:|          ...|.:.....|.:.:::||  |..|    |..|.:
Mouse   534 DNSTATALEVVAGERLYNVVVDTEVTAKKLLEKGELKRRYTIIPLNKISARCIAPETLRVAQNLV 598

  Fly   652 -IDILRIETVLVTESKEIAE---------FLTSDTENVPP------NLTR-------VLVPNLGL 693
             .|.:.:...||....|:.:         |:.::.:|...      .:||       |..|:..|
Mouse   599 GPDNVHVALSLVDYKPELQKGMEFVFGTTFVCNNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTL 663

  Fly   694 EYIPSPNYAVYSTRITPARYIQ--------------------KNVDDRIRQLQMEQSDLQEKEPS 738
            ........|...|:....:.:|                    |||.::.|||: :|.:::.:|..
Mouse   664 SGGARSQAASILTKFQEVKDVQDELRTKENELRALEEELAGLKNVAEKYRQLK-QQWEMKTEEGD 727

  Fly   739 L------EIDYMQHKKVLENTQKVISQKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKS 797
            |      :..|.:.::.|:..:|.|.:....:...:...:||.:|...|:|  ..:..|.:|.|
Mouse   728 LLQTKLQQSSYHKQQEELDALKKTIEESEETLKSTKEIQKKAEEKYEALEN--KMKNAEAEREK- 789

  Fly   798 HLADSGEKIE----KCRLEREMLQEKLLSIQHRQTELESTE---AEERRALEGINKKLTALDTEA 855
            .|.|:.:|::    |.....:.::||...::....|||..:   |...:.|:.:|:.:.|.:
Mouse   790 ELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVNEAIKAYE--- 851

  Fly   856 GEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSELEKARTEAEKLGEFIATTQTEEKI 920
            |::| ||.:.....:|:..:.|..|..:::::..::.::.  :|.   ||.....:...:::.||
Mouse   852 GQIE-KMAAEVAKNKESVNKAQDELMKQKQIITAQDNIIK--DKC---AEVAKHNLQNNESQLKI 910

  Fly   921 RE---AISRYK-------SKI-KQVEELNY--------------------NPEELERGLAELRDE 954
            :|   :||::|       :|: |.:.:.::                    ||:|..:.|.:|::.
Mouse   911 KELDHSISKHKREADDAAAKVSKMLSDYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQKLQEV 975

  Fly   955 LELQSRHLAV------------VDSVVKKLRMAYHQRAQL------------------FQRSRHH 989
            .|...|::.:            .:.::||.|:..:.::::                  :|:....
Mouse   976 KEKLGRNVNLRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQALNIAWQKVNKD 1040

  Fly   990 YFTMVQFQFEQALAM------------RQFKVSFETSDKEKTWKINVFPPSGNETSNTRSLSGGE 1042
            :.::.......|.||            .:|||:.     ..|||           .|...||||:
Mouse  1041 FGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVAL-----GNTWK-----------ENLTELSGGQ 1089

  Fly  1043 RSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEIL 1084
            ||...:||:..:......|.|.|||.|...|..:.:.|.::|
Mouse  1090 RSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQML 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	42/142 (30%)
		SMC_prok_B	115..1076	CDD:274008	233/1202 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	18/58 (31%)
Smc2	NP_032043.3	SMC_N	2..1167	CDD:426784	235/1212 (19%)