Protein Alignment SMC6 and SMC3

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: XP_316422.3
• Gene: SMC3 / 1277000
• VectorBaseID: AGAMI1_002538
• Length: 1201
• Species: Anopheles gambiae
• Alignment Length: 1222
• Identity: 260/1222 - (21%)
• Similarity: 442/1222 - (36%)
• Gaps: 353/1222 - (28%)

  Fly   117 FGPNINFLVGNNGSGKSAVITALALGLTSSARATN-RASSIQKLIKNG----EVSATISITLSNS 176
            |....|.:||.||||||....|:...|  |...|: |....|.|:..|    .:||.:.|...||
Mosquito    23 FDKRHNVVVGRNGSGKSNFFYAIQFVL--SDEFTHLRPEQRQALLHEGTGPRAMSAYVEIIFDNS 85

  Fly   177 GLR-PF-KADIFGPHLTVVRQIRHSSSTYDLQDARGKSVSKKV---SDIRRMLLCFGINVENPIF 236
            ..| |. |.:|:     :.|.|......|.|        :|||   |::..:|...|.:..||.:
Mosquito    86 DNRVPIDKEEIY-----LRRVIGAKKDQYFL--------NKKVVPRSEVVNLLESAGFSNSNPYY 137

  Fly   237 VLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTECHALRRHFTQELEQLEKKKEMMIKHIA 301
            ::.|....: :.....:...|||.:.....|......|...|       |.:.|.|.|.:.:::.
Mosquito   138 IVKQGKINQ-MATAPDSHRLKLLREVAGTRVYDERKEESMNL-------LRESEGKLEKISEYLR 194

  Fly   302 AEEEKLSILEDKEMVKENLQQCKTKLAWMAVTSYQNELNNLEHSI---KLIENKKASLEQTTSKK 363
            ..|::|..||::   ||.|.:.:         .:......||:.|   :|.|.:| .||:...::
Mosquito   195 TIEDRLKTLEEE---KEELSEYQ---------KWDKARRTLEYVIYETELKETRK-QLEELDGQR 246

  Fly   364 ESTQATMNQKLKEFEASKNQILATQKFQ--DERLKTAKKAVQD---------------------L 405
            :|             :...|:|.||:.|  .:|||.|:||::|                     |
Mosquito   247 KS-------------SGDKQLLLTQEIQKAQDRLKNAQKALKDAKKDVVTAKDEKSVLATEHQQL 298

  Fly   406 LLEASQVKAKIGNAERRMRED----QRSYDECEKL---IGNYHADFNRVN------EQREENANK 457
            |.|.:::...|.:....::.|    :|:..|.|:|   |.....:..:|.      .::||..::
Mosquito   299 LREKTKLDLTISDLSDEVQGDNKSKERAEQELERLKITIAEKEKELEQVRPRYEAMRRKEEECSR 363

  Fly   458 IEMLKKQVVKSEEIIAQ----------------LRAE------------------QQEIKRDIT- 487
            ...||:|  |.:|:.|:                ::.|                  |.::|:||.
Mosquito   364 ELNLKEQ--KRKELYAKQGRGSQFSSKEERDKWIQGELKSLNKQIKDKISHQNKLQDDLKKDIAK 426

  Fly   488 ------SVQERLDAVKNGRIQL----------------HKSKQNISWEIEALSRNKSNKLSVYGE 530
                  .:||..::.:..|:|:                ::|.:|..|:.|..   .:..||.|.|
Mosquito   427 QGELEKKIQEHTESFEQLRVQIDEHNKNFYELKKKKDHYQSLRNDIWKKETA---VTQTLSGYKE 488

  Fly   531 QTIQVVHALRTQYA-----GSNMHR------MPRGPLGQYISAPNPKYRDLIENQLMHCLRSF-- 582
            :..:...|||:...     |.:..|      :.||  .:|....|..|..:|||  .:|.:|.
Mosquito   489 ELARADQALRSMAGKPILNGRDSVRKVLESFLQRG--REYADIANAYYGPVIEN--FNCDKSIYT 549

  Fly   583 -------------IVGSDR-ERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQ------ 627
                         ||.||| ..|.|:.:.:.|..|             .|..:..|::|
Mosquito   550 AVEVTAGNRLFHHIVESDRVGTQILKEMNKQKLPG-------------EVTFMPLNRLQVKIHDY 601

  Fly   628 PTTPNTTVLIDEISCDDPV--VMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPN 690
            |..|::..:|.::..::..  .:.|:..     ..|:..:.|.|..|...|
Mosquito   602 PEDPDSIPMISKLKYEEQYDKALRYIFG-----KTLICRNLERATELAKST-------------- 647

  Fly   691 LGLEYIPSPNYAVYSTRITPARYIQKNVDDRIRQLQMEQSD----LQEKEPSLEIDYMQHKKVLE 751
             ||:.:......|.|.......|.  |......::|.::|:    :||.|..|.....:.|:...
Mosquito   648 -GLDCVTLEGDQVSSKGSLTGGYF--NTSRSRLEMQKKRSEYSQLIQEHEKELADFRAELKQTEA 709

  Fly   752 NTQKVIS--QKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKS----HLADSGEKIE--- 807
            |...::|  ||:.   ..|.:::.|.:||.........||...:|.:|    .||.....:|
Mosquito   710 NINSIVSEMQKTE---TKQGKSKDAFEKIQADIRLMKDELSRIERFRSPKERSLAQCKANLEAMT 771

  Fly   808 --KCRLEREMLQEKL--LSIQHRQTELESTEAEERR----------------------------- 839
              |..||.|:.||.:  ||:|. |.|::|...|.||
Mosquito   772 STKEGLENELHQELMSQLSVQD-QHEVDSLNDEIRRLNQENKEAFTSRMSLEVTKNKLENLLTNN 835

  Fly   840 ----------ALEGIN-----KKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGE 889
                      ||:.|:     ::||....|....|.:::.:....||..|:..:.|:.::.:..|
Mosquito   836 LFRRKDELVQALQEISVEDRKRQLTNCRNEVVATEKRIKKVLTDTEEVDRKLSEALKQQKTLQKE 900

  Fly   890 KETVLSELEKARTEAEKLGEFIATTQTEEK-IREAISRYKSKIKQVEEL-NYNPEELERGLAELR 952
            .|:.:.:.::|:.:.|:.|:.:....|:|. :|:.|.....||..:..| |.:....:..|..|.
Mosquito   901 LESWIQKEKEAQEKLEEDGKRMEKWATKENMLRQKIDECTEKIAGLGALPNVDASYQKMSLKSLF 965

  Fly   953 DELELQSRHLAVVDSVVKKL-----------RMAYHQRA----------QLFQRSRHHYFTMVQF 996
            .|||..::||...:.|.||.           ...|.::|          :|.|.........:||
Mosquito   966 KELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYKRKAELDVGKDKICELMQLLEARKVEAIQF 1030

  Fly   997 QFEQALAMRQFKVSF----------------------------ETSDKEKTWKINV-FPPSGNET 1032
            .|.|..|  .|...|                            ||||:.....|.| |.....|.
Mosquito  1031 TFRQVAA--NFSEVFKKLVPQGNGHLILRTTNDQEGNDMEREVETSDEFTGIGIRVSFTQVDAEM 1093

  Fly  1033 SNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEIL 1084
            .....||||::|...::|:..:......|||..||.|...|..:|..:.:::
Mosquito  1094 REMNQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRSAVADMI 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	40/140 (29%)
		SMC_prok_B	115..1076	CDD:274008	259/1212 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	15/58 (26%)
SMC3	XP_316422.3	SMC_N	2..1181	CDD:426784	260/1222 (21%)