Protein Alignment SMC6 and SelR

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: XP_061501760.1
• Gene: SelR / 1272971
• VectorBaseID: AGAMI1_003951
• Length: 1342
• Species: Anopheles gambiae
• Alignment Length: 1144
• Identity: 342/1144 - (29%)
• Similarity: 565/1144 - (49%)
• Gaps: 95/1144 - (8%)

  Fly    26 PTRKRSKQQFVAEAEPDFVEEETEKYANASTSQTARSRNKQARQTTLNMSQRSV-NFNLTSEL-S 88
            |||||   ..:..|..:|:...:|:   ....:|........|...||...|.: :..:..|. :
Mosquito   220 PTRKR---YCINSASIEFMPAGSER---KDVCKTGYEPTFFLRTFDLNNGFRFIASAAIVIECQA 278

  Fly    89 IPNAFD-------RCGKVISMRLTNFMCHSNLFIEFGPNINFLVGNNGSGKSAVITALALGLTSS 146
            :|::.|       |.|||:.:.|.|||||.::.:||....|.|||.|||||||::.|:.:||..:
Mosquito   279 VPSSQDPDGLSLFRNGKVLKIVLKNFMCHRHMVVEFNKRANLLVGKNGSGKSAILAAMTIGLGCN 343

  Fly   147 ARATNRASSIQKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQIRHS-SSTYDLQDARG 210
            |..|||.||::.|||:||..|.|.|.|.|:....:..:.:|..:...|.:..| ..:|.|::..|
Mosquito   344 AGQTNRCSSLKDLIKHGETQAVIEIHLENTAFNAYDPERYGGRIICERTLNASGGGSYKLKNEHG 408

  Fly   211 KSVSKKVSDIRRMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLTEC 275
            ::||...::::::||.|.|.|:|||.||||:.||..||:.:.:..|....||||:|.....|.||
Mosquito   409 QTVSTSRAELQKILLAFNIQVDNPICVLNQDLARSLLKDSDESKQYTFFSKATQIDTIKQKLNEC 473

  Fly   276 HALRRHFTQELEQLEKKKEMMIKHIAAEEEKLSILEDKEMVKENLQQCKTKLAWMAV-------T 333
            ..:.:.....|...||..|.:...|...|||.|.||....:.|.|.:.:.||||..|       .
Mosquito   474 AVIAKKARDVLVVKEKSLEYLSNEIVVLEEKQSNLESAGRMGELLSELQAKLAWRNVIDQEEQLA 538

  Fly   334 SYQNELNNLEHSIK----LIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQDER 394
            :..:||..|..||:    .|.|::|.:.:|.|..::.:|.:..|.:|:.|.|           |.
Mosquito   539 AVDDELKKLRTSIEEQEHRIRNREALVAKTDSTIDTYRADIESKKQEYVALK-----------EA 592

  Fly   395 LKTAKKAVQDLLLEASQVKAKIGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENANKIE 459
            ..|.::.:||:..:.:.::..:.||..|:...|:...:.|:          .:.|:..:..:::|
Mosquito   593 YGTVRRTLQDVQAKQAAIERGMRNASERVTRIQKDARQIEQ----------DLQERNRDGLSQVE 647

  Fly   460 MLKKQVVKSEEIIAQLRAEQQEIKRDITSVQERLDA-------VKNGRIQLHK---SKQN----I 510
            . :||.|::|:  |||:....|:...|.|.|..:|.       ||:.|.:.|.   :||:    |
Mosquito   648 Q-RKQAVETEK--AQLKERNDELASMIASAQREVDLMYNTMAHVKDAREEKHHERCAKQSETTRI 709

  Fly   511 SWEIEALSRNKSNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAPNPKYRDLIENQL 575
            ..::|.......:||:|||.....:|..:|..:.......||||||||||...|.|:..::|..|
Mosquito   710 EKQLEQFESAPRSKLAVYGTNMPALVARIRQLHQQGQFSEMPRGPLGQYIEVRNKKWSGIVETAL 774

  Fly   576 MHCLRSFIVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQPTTPNTTVLIDEI 640
            ..||.:|.|.:..:.::|.|||:.:|......||.|..|...:|||....|| ....|.:|::.|
Mosquito   775 GGCLSAFFVSTQEDWRTLDALLKREFPDLQNRTIFTGRFVKELYDVRSGCVQ-EQDGTHLLMNLI 838

  Fly   641 SCDDPVVMNYLIDILRIETVLVTESKEIAEFLTSDTENVPPNLTRVLVPNLGLEYIPSPNYAVYS 705
            ..:||||||.|||...|:|:||||.:.:|..|||:.||||.||::|:|.....|:.|.|.|..|.
Mosquito   839 KVNDPVVMNRLIDSAAIDTILVTEHQSVAIQLTSEIENVPQNLSKVIVAEPCAEFFPQPKYRSYG 903

  Fly   706 TRITPARYIQKNVDDRIRQLQMEQSDLQEKEPSLEIDYMQHKKVLENTQKVISQKSTMIGQHQSR 770
            .:..|.||:|.::|:..|..|..:..||.:...|...|.:..:.|:...:.:.|:.    ||..:
Mosquito   904 LQQKPPRYLQVSMDELKRHTQQRREQLQRELNELNSAYAKEDERLQEMTRKLHQRQ----QHMKK 964

  Fly   771 NQKAM----QKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCRLEREMLQEKLLSIQHRQTELE 831
            .|:.:    |::.:|....::...|...|:..|..|...:.|.:...|..|.||..::....:.|
Mosquito   965 LQQELLTNEQQLQQLAGVVFEGETEETTLREELEHSRTILAKLQKGIEEEQAKLDQVRRTVQQEE 1029

  Fly   832 STEAEERRALEGINKKLTALDTEAGEVESKMRSLDLHYEENTRRFQKTLQLERKMLGEKETVLSE 896
            .|...::.|:..:..::..:.....:.:.....|..:::...:..:::.:...:....:..:.:.
Mosquito  1030 QTAQAKKDAMGAVEAEIARIQASIDKEQQARHDLQTNHKVKQQALKRSTESMEERKRTRVALSAA 1094

  Fly   897 LEKARTEAEKLGEFIATTQTEEKIREAISRYKSKI----KQVEELNYNPEELERGLAEL------ 951
            ||:||.||.:.||   .....|:| .::.:.|.||    |::..::...::||..:.||
Mosquito  1095 LEQARQEASEKGE---RPDESEQI-PSVEQLKGKIHTTEKRIRLVSATQDKLEDVVEELEGKNRE 1155

  Fly   952 RDELELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHYFTMVQFQFEQALAMRQFKVSFETSDK 1016
            ||||...|..|..:..:::.:|.:   |.....:...|....|:.:|...:.:|.:......:.:
Mosquito  1156 RDELIRYSTALRDLTQMMRDIRKS---RFSHLHKLTTHMALRVKHKFTNIMQIRNYLGKLRVNQE 1217

  Fly  1017 EKTWKINVFPPSG---NETSNTRSLSGGERSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRK 1078
            |....::|.|...   |..|.|:||||||||:.||:.|..|||....||:||||||||||:|||.
Mosquito  1218 ECRLSLSVVPRDANVQNAVSTTKSLSGGERSYATVAFLIALWSCVSTPFFFLDEYDVFTDQVNRH 1282

  Fly  1079 FITEILIGEGLEWLSRQYCFLTPQD-TKVEASNLITVHK 1116
            .||.:|:.|.::...||:||||||| ::|:|:..:|:|:
Mosquito  1283 TITRLLLNEAMKKPDRQFCFLTPQDMSEVQATAELTIHR 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	61/149 (41%)
		SMC_prok_B	115..1076	CDD:274008	296/1003 (30%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	49/94 (52%)
SelR	XP_061501760.1	None