Protein Alignment SMC6 and smc6

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: XP_031758814.1
• Gene: smc6 / 100495796
• -ID: -
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1168
• Identity: 329/1168 - (28%)
• Similarity: 560/1168 - (47%)
• Gaps: 126/1168 - (10%)

  Fly    16 GSESDGSTAEPTRKRSKQQFVAEAEPDFVEEETEKYANASTSQTARSRNKQARQTTLNMSQRSVN 80
            |...:||...|..:|.|::..||...|:..:..:  |..|.|... :.:::.|... |.|....|
 Frog     2 GKRKEGSPIAPNSQRKKERQEAEGTYDYEGDNVQ--AGPSVSNDC-AHHREPRDEA-NNSHTDRN 62

  Fly    81 FNLTSELSIPNAFDRCGKVISMRLTNFMCHSNLF-IEFGPNINFLVGNNGSGKSAVITALALGLT 144
            :..:......:.....|.:.|:.|.||||||.|. ..||||:||:||||||||||::|||.:||.
 Frog    63 YGNSVSCDSQSCTGEVGIIESISLRNFMCHSMLGPFRFGPNVNFVVGNNGSGKSAILTALIVGLG 127

  Fly   145 SSARATNRASSIQKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQI-RHSSSTYDLQDA 208
            ..|..|||.|:|:..||.||..|.|||||.|.|...:|.|:||..:||.::| .....||.|:.|
 Frog   128 GKAAFTNRGSTIKGFIKGGENFAEISITLRNRGQDAYKPDVFGNSITVRQRITTEGGRTYKLKSA 192

  Fly   209 RGKSVSKKVSDIRRMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLLMKATQLDVCTSSLT 273
            .|..:|.|..::..:|..|.|.|:||:.||.||.::.||:....:..||..||||||:
 Frog   193 TGAVISNKKEELTMILDHFNIQVDNPVSVLTQEMSKLFLQSKNESDKYKFFMKATQLE------- 250

  Fly   274 ECHALRRHFTQELEQLEKKKEMMIKHIAAE------------EEKLSILEDKEMVKENLQQCKTK 326
               .::..::..:|...|..:.:  .|.:|            ||..:.:.....:|.||...|..
 Frog   251 ---QMKEDYSYIMETKSKTHDQV--KIGSERLCDLRQDCIQKEESFNSIASLGEMKMNLDNLKNS 310

  Fly   327 LAWMAVTSYQNELNNLEHSIKLIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQKFQ 391
            :||..|.       ..|..||.|.::..:.|..|.|.|       |::.|.:...|  :|.:||
 Frog   311 MAWALVI-------EAEKQIKPIRDQIVTEEGHTVKYE-------QRIDECQGKVN--IAEEKF- 358

  Fly   392 DERLKTAKKAVQDLLLEASQVKAKIGNAERRMREDQRSYDECEKLIGNYHADFNRVNEQREENAN 456
                :..::.:..:..||:::|.|:...:..:::.::||::.|........:..|..:..|:.:.
 Frog   359 ----RAKQEELDKITQEAAELKPKVIALKDDVQKKRKSYNDAEASYNRQIMELKRSEKDAEQLSK 419

  Fly   457 KIEMLKK---------QVVKSEEIIAQLRAEQQEIK-RDIT------SVQERLDAVKNGRIQLHK 505
            :||.|||         ::.:.:| |||:...::|:: .|||      .:||.::..|...|::..
 Frog   420 RIEELKKRDGNASEREKMARQQE-IAQITERKEELQNHDITISQKIKQLQEAIEKHKEKWIRIEN 483

  Fly   506 SKQNISWEIE-------ALSRNKSNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLGQYISAP 563
            .:||:...:|       .|..:|:::|..:|:....::.|:...|......:.|.||||.||...
 Frog   484 EEQNVKQRLEQHKRQLRELHESKTDRLKRFGKNIPSLLAAIDEAYNLGRFRKKPFGPLGAYIHLK 548

  Fly   564 NPKYRDLIENQLMHCLRSFIVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVSRNKVQP 628
            :.:....:|..|...|.:|...:.::...|:.::..::..|..|.||.|.|.:.|||||:.  ..
 Frog   549 DQELALAVECCLKGLLFAFCCDNHQDEGILQNIMSKQYSQGRRPQIIVSEFWNNVYDVSQR--AS 611

  Fly   629 TTPNTTVLIDEISCDDPVVMNYLIDILRIETVLV----TESKEIAEFLTSDTENVPPNLTRVLVP 689
            ..||...::..:..|.|||.|.|||:..|||:|:    ||::||.:      :.|||...|....
 Frog   612 FHPNHPTVLTALEIDHPVVANCLIDMRGIETILIIKDKTEAREIMQ------KRVPPRNCREAFT 670

  Fly   690 NLGLEYIPSPNYAVYSTRITPARYIQKNVDDRIRQLQMEQSD-------LQEKEPSLEIDYMQHK 747
            ..| :.:.:..|  ||:....|..:.::|:..|..|:.|..|       ||:...|::.|..:::
 Frog   671 GEG-DQVYTNRY--YSSDTRRATLLSRDVEAEISHLEEELRDFGGQVATLQQSVHSVDKDIKENE 732

  Fly   748 KVLENTQKVISQKSTMIGQHQSRNQKAMQKIMELQNFDYQELPEYDRLKSHLADSGEKIEKCRLE 812
               :|.:|..:.|.    |.|:..:...::|.||:|.:.|...:...|:...|::.|.||..:.|
 Frog   733 ---DNLRKYYNSKK----QIQTELRTLSEQIAELENVEEQPSTDIATLEKEAAENTEIIELVKQE 790

  Fly   813 REMLQEKLLSIQHRQTELESTEAEERRAL-------EGINKKLTALDTEAGEVESKMRSLDLHYE 870
            .|:.||.:.:::...|..||...|.:|.:       |.:.:.|..:|.   |||:..|. ..||.
 Frog   791 VELAQENMGNLKLLLTTAESNYEEIKRKIISVSDVAEPVKEDLHRIDQ---EVENCKRH-KKHYV 851

  Fly   871 ENTRRFQKTLQLERKMLGEKETVLSELEKARTEAEKL-GEFIATTQTEEKIREAISRYKSKIKQV 934
            :..::....:|..::.:..||   .|||...::|:.: .|.|..::|...:...|:|.:.||...
 Frog   852 DKLKKHLDRIQKRKEEVAGKE---QELEVKISQAKYICPERIEVSRTARSLDTEINRLREKINSE 913

  Fly   935 EELNYNPEELERGLAELRDELELQSRHLAVVDSVVKKLRMAYHQRAQLFQRSRHHYFTMVQFQFE 999
            |.|:.|.||:.....|.::..:...|.:..::..:..|.....||.:.||:.:.......:..|.
 Frog   914 EVLHGNREEIIMQYYEAKERYQDAERKIKHLNRFITLLDTIMEQRHECFQKFQRSLTLRCKCFFN 978

  Fly  1000 QALAMRQF--KVSFETSDKEKTWKINVFPPSGN--ETSNTRSLSGGERSFTTVSLLKGLWSTSDH 1060
            ..|:.|:.  |::|:  .|.:|..|.|.|..||  |.|:.||||||||||:.|..:..|||.::.
 Frog   979 SLLSQRKHSGKINFD--HKNETLSITVQPGEGNKAELSDMRSLSGGERSFSNVCFILSLWSIAES 1041

  Fly  1061 PFYFLDEYDVFTDEVNRKFITEILIGEGLEWLSRQYCFLTPQD-TKVEASNLITVHKLEAPER 1122
            ||..|||:||:.|.|||:...::::........||:..||||: :.:.:|::|.:.:::.|||
 Frog  1042 PFRCLDEFDVYMDMVNRRISMDMMLKVADSQRFRQFILLTPQNMSSLPSSSIIRILRMKDPER 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	73/150 (49%)
		SMC_prok_B	115..1076	CDD:274008	289/1019 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	38/97 (39%)
smc6	XP_031758814.1	P-loop containing Nucleoside Triphosphate Hydrolases	81..>237	CDD:476819	74/155 (48%)
		SMC_prok_B	98..>966	CDD:274008	253/926 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1009..1107	CDD:476819	39/96 (41%)