Protein Alignment SMC6 and smc6

DIOPT Version :10

• Sequence 1: NP_651228.1
• Gene: SMC6 / 42876
• FlyBaseID: FBgn0266282
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: XP_004918255.2
• Gene: smc6 / 100495634
• XenbaseID: XB-GENE-6071284
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 1186
• Identity: 328/1186 - (27%)
• Similarity: 564/1186 - (47%)
• Gaps: 156/1186 - (13%)

  Fly    16 GSESDGSTAEPTRKRSKQQFVAEAEPDFVEEETEKYANASTSQTARSRNKQARQT---------- 70
            |...:||...|:.:|.||:   :...|..:||....|..|.|.......||.::.
 Frog     2 GKRKEGSPIAPSSQRKKQR---QEVDDTYDEEDYVQAGPSASNDYGHNKKQRKEANNSLDTLDYD 63

  Fly    71 ---TLNMSQR-SVNFNLTSELSIPNAFDRCGKVISMRLTNFMCHSNLF-IEFGPNINFLVGNNGS 130
               :|..||| |.:.:.|.::.|         :.|:.|.||||||.|. ..||||:||::|||||
 Frog    64 NSMSLASSQRGSASQSGTGDVGI---------IESISLRNFMCHSMLGPFRFGPNVNFVIGNNGS 119

  Fly   131 GKSAVITALALGLTSSARATNRASSIQKLIKNGEVSATISITLSNSGLRPFKADIFGPHLTVVRQ 195
            |||||:|||.:||...|..|||.|||:..:|.|:..|.|.|||.|.|...:|.|:||..:||.::
 Frog   120 GKSAVLTALIVGLGGKAAVTNRGSSIKGFVKEGQTFAEIFITLRNRGQDAYKPDVFGNSITVQQR 184

  Fly   196 I-RHSSSTYDLQDARGKSVSKKVSDIRRMLLCFGINVENPIFVLNQEAAREFLKELEPASNYKLL 259
            : ...|.||.|:.|.|..||.|..::..:|..|.|.|:||:.||.||.::.||:....:..||..
 Frog   185 LTTDGSRTYKLKSATGAVVSNKKEELTAILDHFNIQVDNPVSVLTQEMSKHFLQSKNESDKYKFF 249

  Fly   260 MKATQLDVCTSSLTECHALRRHFTQELEQ-LEKKKEMMIKHIAAEEEKLSILEDKEMVKENLQQC 323
            ||||||:......:.....:.....::|. .|:.:::.::.|..||...||....|| ||.|:..
 Frog   250 MKATQLEQMKEDYSYIMETKSRTHDQVENGSERLRDLRLECIQKEERFKSIASLGEM-KEKLEDL 313

  Fly   324 KTKLAWMAVTSYQNELNNLEHSIKLIENKKASLEQTTSKKESTQATMNQKLKEFEASKNQILATQ 388
            |.|:||..|...:.::             |..:||..: :|.......||:.|.:...|  :|.:
 Frog   314 KNKMAWALVIEAEKQI-------------KPFIEQIAA-EEGRTVKYKQKIDECQGKVN--IAEE 362

  Fly   389 KFQDERLKTAKKAVQDLLLEASQVKAKIGNAERRMRED----QRSYDECEKLIGNYHADFNRVNE 449
            ||     :..::.:.::..||..:|.: |.|   ::||    ::||:|.|.|...:..:..|:..
 Frog   363 KF-----RAKQEELDNITQEAVALKPQ-GIA---LKEDAQKKRKSYNESEVLYNRHRMELKRLER 418

  Fly   450 QREENANKIEMLKKQVVKSEEI--------IAQLRAEQQEI-KRDITS------VQERLDAVKNG 499
            ..::...:||.|||....:.|.        |||:|...:.: .::||:      .|:.::..|..
 Frog   419 DADQLHKRIEELKKSADNASESEKMARQKEIAQIRDRMKALHDKEITTNQQIHQFQQAIEKYKEE 483

  Fly   500 RIQLHKSKQNISWEIE-------ALSRNKSNKLSVYGEQTIQVVHALRTQYAGSNMHRMPRGPLG 557
            ||::...::|:...:|       .|..:|:::|..:|:....::.|:...|......:.|.||||
 Frog   484 RIRIGNEERNVKQRLEQHKRQLRELHESKTDRLRRFGQNMPALLAAIDEAYKLGRFRKKPVGPLG 548

  Fly   558 QYISAPNPKYRDLIENQLMHCLRSFIVGSDRERQSLRALLQNKFQGGNMPTIITSPFTDRVYDVS 622
            ..|...:.:....:|..|...|.:|...:.::.:.|:.::..::..|..|.||.:.|.|:|||||
 Frog   549 ACIHLKDQELALAVECCLKGLLFAFCCDNHQDERMLQNIMSREYPRGRRPQIIVNEFRDQVYDVS 613

  Fly   623 RNKVQPTTPNTTVLIDEISCDDPVVMNYLIDILRIETVLV----TESKEIAEFLTSDTENVPPNL 683
            |...  ..||...::..:..|.|||.|.|||:..:||:|:    .|::||.:      :..||..
 Frog   614 RRAT--FHPNHPTVLTALEIDHPVVANCLIDMRGVETILIIKGTDEAREIMQ------KRAPPRN 670

  Fly   684 TRVLVPNLGLEYIPSPNYAVYSTRITPARYIQKNVDDRIRQLQME-------QSDLQEKEPSLEI 741
            .|......| :.:.:..|  ||:....|..:.::|:..|..|:.|       .:..|::..|::.
 Frog   671 CREAFTGEG-DQVYTNRY--YSSDTRRAAILSRDVEAEISHLEKELRNFGGQMAKFQQRLHSVDK 732

  Fly   742 DYMQHKKVLENTQKVISQKSTMIGQHQSRNQKAM------QKIMELQNFDYQELPEYDRLKSHLA 800
            |..:::.:|..             .|.|:.|..:      ::|.||:|.:.|...:...|:....
 Frog   733 DVKENEDILRQ-------------YHNSKKQIQIDLRAFSERIAELENVEEQPSIDIATLEGEAE 784

  Fly   801 DSGEKIEKCRLEREMLQEKLLSIQHRQTELESTEAEERRALEGINKKLTALDTEAGEVESKMRSL 865
            ::..|||..:.|.|:.:|.:.:::...|..||.       .|.|.:|::::...|..|:..:..:
 Frog   785 ENLNKIELVKQEMELTKENMGNLKLLLTMAESN-------YEEIKRKISSVSEVAEPVKEDLHRI 842

  Fly   866 D----------LHYEENTRRFQKTLQLERKMLGEKETVLSELEKARTEAEKL-GEFIATTQTEEK 919
            |          .||.:..:.....:|..::.:..||   .|||...::|:.: .|.|..::|...
 Frog   843 DQEVENCKRHKKHYVDKLKEHLDRIQKRKEEVAGKE---QELEVKISQAKCVCPERIEVSRTARS 904

  Fly   920 IREAISRYKSKIKQVEELNYNPEELERGLAELRD---ELELQSRHLAVVDSVVKKLRMAYHQRAQ 981
            :...|:|.:.||...|.|:.|.||:.:...|.::   ::|.:.:||   ...:|.|.....||.:
 Frog   905 LDTEITRLREKINSEEVLHGNREEIIKQYHEAKERYQDVEGKVKHL---KRFIKLLDDIMAQRYK 966

  Fly   982 LFQRSRHHYFTMVQFQFEQALAMRQF--KVSFETSDKEKTWKINVFPPSGNET--SNTRSLSGGE 1042
            .:|:.|.......:..|:..|:.|.:  |::|:  .|.:|..|.|.|..||:.  |:.|||||||
 Frog   967 SYQQFRRCLTFRCKIYFDSLLSQRAYSGKINFD--HKNETLSITVQPGEGNKAALSDMRSLSGGE 1029

  Fly  1043 RSFTTVSLLKGLWSTSDHPFYFLDEYDVFTDEVNRKFITEILIGEGLEWLSRQYCFLTPQD-TKV 1106
            |||:||..:..|||.::.||..|||:||:.|.|||:...::::........||:..||||: :.:
 Frog  1030 RSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRISMDMMLSMADSQRFRQFILLTPQNMSSL 1094

  Fly  1107 EASNLITVHKLEAPER 1122
            .:::||.:.:::.|||
 Frog  1095 PSTSLIRILRMKDPER 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	NP_651228.1	P-loop containing Nucleoside Triphosphate Hydrolases	99..>248	CDD:476819	72/150 (48%)
		SMC_prok_B	115..1076	CDD:274008	283/1023 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1027..1122	CDD:476819	38/97 (39%)
smc6	XP_004918255.2	P-loop containing Nucleoside Triphosphate Hydrolases	87..>243	CDD:476819	73/155 (47%)
		SMC_prok_B	104..1087	CDD:274008	288/1047 (28%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1015..1113	CDD:476819	39/96 (41%)