DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHORD and ITGB1BP2

DIOPT Version :9

Sequence 1:	NP_651226.1	Gene:	CHORD / 42874	FlyBaseID:	FBgn0029503	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_036410.1	Gene:	ITGB1BP2 / 26548	HGNCID:	6154	Length:	347	Species:	Homo sapiens

Alignment Length:	340	Identity:	143/340 - (42%)
Similarity:	194/340 - (57%)	Gaps:	23/340 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CYNRGCGQLFDPQTNNDESCRHHPGEPFFHDAYKGWSCCNKKSVDFTEFLNIKGCTLAKHSNVKP 68
            |.|:||||.|||.||..:||.||||.|.||||.||||||.|::|||:|||||||||:..|...|.
Human     5 CRNKGCGQHFDPNTNLPDSCCHHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTMGPHCAEKL 69

  Fly    69 PE---PEKPVKDES-DKDEVIEVRAPIREAL--PRPPIDSPLTVIQPTVAPALKDMVFAVK---- 123
            ||   ||.|....| .:.:.:.|.....|.|  .||..:.||.::...::.|| :|....|
Human    70 PEAPQPEGPATSSSLQEQKPLNVIPKSAETLRRERPKSELPLKLLPLNISQAL-EMALEQKELDQ 133

  Fly   124 TPAAQKSSDAIEVGTTCKNNGCTYSFTGNSSDFGECTYHPGVPIFHEGMKFWSCCQKRTSDFSQF 188
            .|.|...| .|..|::|:|.||...:.|..||...||||||.|.||||||.||||..:|.||..|
Human   134 EPGAGLDS-LIRTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAF 197

  Fly   189 MAQKGCTYGEHKWVKENDDKKVVQCRYDWHQTATNVVMAIYAKKYDYSQSVIELNPIRLHVNLVF 253
            :||.||..|.|.|.|:    ....||:|||||.:.||:.:|.:....:.:.::.:...|||::||
Human   198 LAQPGCRVGRHDWGKQ----LPASCRHDWHQTDSLVVVTVYGQIPLPAFNWVKASQTELHVHIVF 258

  Fly   254 PEQDNARFDLDLELRGIVNVSNASAHMYGTKVEIKLPKLEPGSWSNLNFPNKKLPVVKKSQ--VE 316
              ..|..|...::|.|::||..:|..:..::|||.|.|.:||||:.|..|:   .:.||::  |.
Human   259 --DGNRVFQAQMKLWGVINVEQSSVFLMPSRVEISLVKADPGSWAQLEHPD---ALAKKARAGVV 318

  Fly   317 EKKKQEESDEEFFDL 331
            .:..:||||:...||
Human   319 LEMDEEESDDSDDDL 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHORD	NP_651226.1	CHORD	3..63	CDD:282781	41/58 (71%)
		CHORD	138..199	CDD:282781	33/60 (55%)
		p23_melusin_like	213..301	CDD:107238	31/87 (36%)
ITGB1BP2	NP_036410.1	CHORD	3..64	CDD:368213	41/58 (71%)
		SH3-binding. /evidence=ECO:0000255	28..31		2/2 (100%)
		SH3-binding. /evidence=ECO:0000255	70..78		4/7 (57%)
		CHORD	148..208	CDD:368213	33/59 (56%)
		SH2-binding. /evidence=ECO:0000255	158..161		0/2 (0%)
		SH3-binding. /evidence=ECO:0000255	172..175		2/2 (100%)
		p23_melusin_like	218..304	CDD:107238	31/87 (36%)
		SH2-binding. /evidence=ECO:0000255	234..237		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..347		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141005
Domainoid	1	1.000	105	1.000	Domainoid score	I6659
eggNOG	1	0.900	-	-		E1_KOG1667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51840
OrthoDB	1	1.010	-	-		D1163528at2759
OrthoFinder	1	1.000	-	-		FOG0002255
OrthoInspector	1	1.000	-	-		otm41886
orthoMCL	1	0.900	-	-		OOG6_102230
Panther	1	1.100	-	-	O	PTHR12621
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720