DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc2 and apc

DIOPT Version :10

Sequence 1:NP_477430.1 Gene:Apc2 / 42871 FlyBaseID:FBgn0026598 Length:1067 Species:Drosophila melanogaster
Sequence 2:XP_002936457.1 Gene:apc / 779466 XenbaseID:XB-GENE-480855 Length:2833 Species:Xenopus tropicalis


Alignment Length:1785 Identity:440/1785 - (24%)
Similarity:627/1785 - (35%) Gaps:763/1785 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ELTRNFLELSRNPETCTALRSSDCIQLLVQILHANDE---------GLSTAKKYASQALHNIVHN 67
            :::|..|.:|.:.::|.|:|.|.|:.||:|:||.||:         |...|:..||.|||||:|:
 Frog   331 DMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHS 395

  Fly    68 NPEEKERQREVKMLRLLDQILDYCNFLHTQLQSGGEAIADDEDRHPL---------AAMKLLMKA 123
            .|::|..:||:::|.||:||..||.......::..:.:  |:|::|:         .|:.:|||.
 Frog   396 QPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGM--DQDKNPMPAPVDHQICPAVCVLMKL 458

  Fly   124 SFDEEHRQTMCELGALKAIPNLVHLDHAVHGPAAGREQCNALRSYGLMALTNLTFGDENVHNKSY 188
            |||||||..|.|||.|:||..|:.:|..::| .........||.|..||||||||||  |.||:.
 Frog   459 SFDEEHRHAMNELGGLQAIAELLQVDCEMYG-LINDHYSVTLRRYAGMALTNLTFGD--VANKAT 520

  Fly   189 LCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLARAAMQNKNEN 253
            ||..:..|..::|||.:..::|.||:|.||||||||||.:.|....|:|:|.:|...|:..|.|:
 Frog   521 LCSMKSCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALDVKKES 585

  Fly   254 TLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAV 318
            |||::|||||||||||:.|||:.|:||||||||||.|:|...:.||.|||:.|||||||||.||.
 Frog   586 TLKSVLSALWNLSAHCTENKADICSVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIAT 650

  Fly   319 CEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAIPLLRALISS 383
            .|.:|||||..|||..|||.|||.|||:|||:||||||||||..:||:.|.|..|:.:|:.||.|
 Frog   651 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNAKDQEALWDMGAVSMLKNLIHS 715

  Fly   384 KNSMIAEGSASALKNLVNFRATQELMPN--GDGGSLP-------------LDKE----------- 422
            |:.|||.|||:||:||:..|..:....|  ..|.|:|             ||.:           
 Frog   716 KHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSVPSLHVRKQKALEAELDAQHLSETFDNIDN 780

  Fly   423 -------------------------AGHGGTLPR--RFSSLRL--------------SSNPTGSL 446
                                     :.|..::.|  .||...|              ||:|..::
 Frog   781 LSPKTTHRNKQRHKQNLCSEYVLDSSRHDDSICRSDNFSLGNLTVLSPYINSTVLPGSSSPRPTM 845

  Fly   447 KKVRP--STVSTTGFLNRKCESRESIYSGKSDSTKYSTKSEGAK--------------------- 488
            :..||  ....|.|..|....:..|..|.|....:.||.::.:|                     
 Frog   846 EGNRPEKDRERTAGLSNYHSATENSGNSSKRIGVQLSTTAQISKVMDEVSNIHMVQEDRSSGSAS 910

  Fly   489 ----------------------NPFEI-------------------------------------- 493
                                  |||..                                      
 Frog   911 EMHCMSDERTSQRKPSSNHPHSNPFSFAKGDSSNRGCPVAFMKMEYKMASNDSLNSVSSTDGYGK 975

  Fly   494 ---VTPTEEQ--------------------------------------PIDYSMKYMEHKPNSS- 516
               |.|:.|.                                      ||:||:||.:.:.||. 
 Frog   976 RGQVKPSVESYSEDDEGKFGSYGHYPAGLAHKIHSANHMDDNDTELDTPINYSLKYSDEQLNSGR 1040

  Fly   517 ----------------------------------------------KTF---------------- 519
                                                          |.|                
 Frog  1041 QSPSQNERWARPKHIIDSEMKQSEQRQPRTTKTTYSSYTENKEEKHKKFPPHFNQPENAPAYARS 1105

  Fly   520 ------------------------------EIDLDQPTDFSARY---------KERRSAQTAQPE 545
                                          :.|.|:.|:||.||         .||::....:|.
 Frog  1106 RGTNNQADQSRVGSNLSNNSKASKPHCQVDDYDDDKTTNFSERYSEGEQQEDENERQNKYNIKPY 1170

  Fly   546 LKSE-------------------------------TNEIRSKELQLTKSSSA-TELRNS------ 572
            ...|                               .::.:.|:.|::.||:. |...||      
 Frog  1171 ASDEHHGEQPIDYSRKYPTDVPSSAQKPSFPYSNNPSKQKPKKEQVSSSSNTPTPSPNSGRQNQL 1235

  Fly   573 --------PGLVAVSAAKQKIATETETETAERPINYCEEGTPGSFSRFDSLNSLTEKPE------ 623
                    |||........|..:.|: ||.:   .||.|.||..|||..||:||:...:      
 Frog  1236 HPNSAQTRPGLNRPKQTSSKPPSITQ-ETIQ---TYCVEDTPICFSRGSSLSSLSSAEDEIEGRE 1296

  Fly   624 ------------KCMPPK------------TPTKTAVLPVHVDGNTPQ--NI---DSA------- 652
                        :...||            ..|:::|.......|..|  ||   ||:       
 Frog  1297 RSSRGQESNNTLQITEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEF 1361

  Fly   653 -----------------------LETPLMFSRRSSMDSLVG-DDETVACEDNGSVISEYSRMQSG 693
                                   .||||||||.:|:.||.. :..::|.....||.||:  |.||
 Frog  1362 SSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESHSIASSIASSVASEH--MISG 1424

  Fly   694 VISPSELPDSPTQSMPQS-------------------PR-----RDRKVSTQNNLDTPEQKPSTV 734
            :||||:|||||.|:||.|                   |:     || ||:.|..:.:..|:...:
 Frog  1425 IISPSDLPDSPGQTMPPSRSKTPPPPQTVHAKKDSSKPKVSGEERD-KVAKQTGVHSAIQRVQVL 1488

  Fly   735 FE-DKLNRFHVEHTPAAFSCATSLSNLS------------------------------------- 761
            .| |.|..|..|.||..||||:|||.||                                     
 Frog  1489 QEADTLLHFATESTPDGFSCASSLSALSLDEPYIQKDVELKIMPPVLENDQGNEAEPEKESTDNL 1553

  Fly   762 -------------MMDD------------------------------------------------ 765
                         |:||                                                
 Frog  1554 NKKENKRSEQEKDMLDDTDDDIDILEECIISAMPRKPSRKNKKVPQPTAGKPPPPVARKPSQLPV 1618

  Fly   766 ----SNANAIRGQRGNDINGNGDAPRSYCTEDTTAVLSKAPSNSDLSILSIPNDLNANEAQPVPA 826
                |:.|.::.|:..:...:.|.||.||.|.|....|.|.|.|||:|.|.||:|..|:.....:
 Frog  1619 YKLLSSQNRLQTQKHVNFTHSDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELTNNDQPNTGS 1683

  Fly   827 PRADVTGMDTRMPAE-------DAISKMRCGGNALP---------------SYLPVSDEMSKYYV 869
            ...|:...|| :|.|       ||..|:....:.|.               |.:|.......|.|
 Frog  1684 LSTDLEKRDT-IPTEGRSTDDTDASKKLNPSTSVLDEDKAEEGDILAECIHSAMPKGKSHKPYRV 1747

  Fly   870 EDSPCTFSVISGLSHLTVGSAK--------------AGPVLKLPM-------------------- 900
            :      .::..::|.:.|::.              ..||..:|.                    
 Frog  1748 K------KIMDQINHTSAGTSSGNNRSMQEIDKNKPTSPVKPMPQSIEFKGRLKKNTESKLNPSS 1806

  Fly   901 -------------RTAEEAQAPKLPPRRSAVQG---DAEPRLPP--------KKSDSLSSLSMDS 941
                         .|:::|. .|:|......:|   |:.....|        .::||||||..| 
 Frog  1807 ENQYSDPRKQNSKNTSKDAN-EKIPNNEERTKGFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFD- 1869

  Fly   942 DDDCNLLSQ------------------------AI-------------AAGSCRP---------- 959
            |||.:|..:                        ||             ..|..:|          
 Frog  1870 DDDIDLSKEKAELRKEKGTKDTDRKGKYKNENPAINQIGKQEQVGPKSLEGRGQPKALVHKPTSF 1934

  Fly   960 -------QPSGASTSSSLAN----------------ASTSTLCRENGQSK----KQVEHGD---- 993
                   |..|.:....:.|                :|.|.:.:||...:    ||.|..:    
 Frog  1935 CPAAKGTQDRGGAKDEKMQNFAIENTPVCFSRNSSLSSLSDIDQENNNKETEPIKQTEMTETQIG 1999

  Fly   994 --KPNYS----------------------SDDSLDDDDDDARSKSLFEQCILSGMHKSN--DALE 1032
              :|..|                      |..|:|.:||      |.::||.|.|.|..  ...:
 Frog  2000 LRRPQTSGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDD------LLQECISSAMPKKKKPSKAK 2058

  Fly  1033 SEGEPPGQRQ--EISARDRFVSNQVRQIES 1060
            :|||......  .|.|.:..::..:|.::|
 Frog  2059 NEGEKSSSNSVGGILAEEPDLTLDLRDLQS 2088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Apc2NP_477430.1 ARM 23..66 CDD:214547 21/51 (41%)
armadillo repeat 29..64 CDD:293788 18/43 (42%)
APC_rep 69..133 CDD:465870 25/72 (35%)
armadillo repeat 72..124 CDD:293788 17/60 (28%)
armadillo repeat 139..176 CDD:293788 13/36 (36%)
armadillo repeat 186..223 CDD:293788 16/36 (44%)
armadillo repeat 273..314 CDD:293788 27/40 (68%)
Arm 319..359 CDD:425727 28/39 (72%)
armadillo repeat 323..357 CDD:293788 25/33 (76%)
Arm 361..400 CDD:425727 19/38 (50%)
armadillo repeat 365..399 CDD:293788 17/33 (52%)
APC_15aa 497..511 CDD:461790 7/51 (14%)
APC_r 596..618 CDD:461781 10/21 (48%)
APC_r 737..760 CDD:461781 13/22 (59%)
APC_r 784..807 CDD:461781 11/22 (50%)
apcXP_002936457.1 APC_N_CC 4..55 CDD:435517
Suppressor_APC <156..207 CDD:463275
ARM 342..394 CDD:214547 21/51 (41%)
APC_rep 395..468 CDD:465870 25/74 (34%)
ARM 461..512 CDD:214547 24/51 (47%)
armadillo repeat 467..510 CDD:293788 17/43 (40%)
ARM 514..555 CDD:214547 19/42 (45%)
armadillo repeat 518..555 CDD:293788 16/36 (44%)
armadillo repeat 565..597 CDD:293788 15/31 (48%)
armadillo repeat 605..646 CDD:293788 27/40 (68%)
ARM 651..691 CDD:214547 28/39 (72%)
armadillo repeat 655..689 CDD:293788 25/33 (76%)
Arm 693..733 CDD:425727 20/39 (51%)
armadillo repeat 697..733 CDD:293788 19/35 (54%)
Arm_APC_u3 734..1019 CDD:435476 32/284 (11%)
APC_u5 1036..1137 CDD:406923 4/100 (4%)
APC_u9 1288..1375 CDD:435478 10/86 (12%)
PTZ00449 <1311..1699 CDD:185628 95/391 (24%)
APC_r 1641..1664 CDD:461781 11/22 (50%)
APC_u13 1666..1719 CDD:406927 15/53 (28%)
SAMP 1720..1741 CDD:461782 2/20 (10%)
APC_u14 1750..1841 CDD:435479 10/91 (11%)
APC_u15 1874..1948 CDD:435480 7/73 (10%)
APC_basic 2226..2566 CDD:428690
EB1_binding 2668..2833 CDD:399141
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.