DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apc2 and apc2

DIOPT Version :9

Sequence 1:	NP_001334699.1	Gene:	Apc2 / 42871	FlyBaseID:	FBgn0026598	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_021335660.1	Gene:	apc2 / 565771	ZFINID:	ZDB-GENE-090422-1	Length:	2119	Species:	Danio rerio

Alignment Length:	1451	Identity:	386/1451 - (26%)
Similarity:	567/1451 - (39%)	Gaps:	457/1451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLELTRNFLELSRNPETCTALRSSDCIQLLVQILHANDEGLST--------AKKYASQALHNIVH 66
            |.|::|..|.:|.:.|:|.|:|.|.|:.|||||||....|.:.        |:..||.||||||:
Zfish   319 REEMSRTLLAMSSSQESCIAMRKSGCVPLLVQILHEGGTGEAAGTGCYSREARSRASAALHNIVY 383

  Fly    67 NNPEEKERQREVKMLRLLDQILDYC--------NFLHTQLQSGGEA--IADDEDRHPLAAMKLLM 121
            :.|:|.:.:||:::|.:|:||..:|        |.|.|....|.:.  |.:..|.....|:..:|
Zfish   384 SQPDEGQARREMRVLHVLEQIRSHCENGWDWIENHLSTPSPGGSKTTEIPEPVDPQICQALCAIM 448

  Fly   122 KASFDEEHRQTMCELGALKAIPNLVHLDHAVHGPAAGREQCN-ALRSYGLMALTNLTFGDENVHN 185
            |.||:||:|:.|.|||.|:||..|:.||..::|  ...|..| |||.|..||:||||:||  |.|
Zfish   449 KLSFEEEYRRAMNELGGLQAIAELMQLDQELYG--MHNEPINMALRRYAGMAVTNLTYGD--VVN 509

  Fly   186 KSYLCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLARAAMQNK 250
            |:.||.::..::.::|||.:..:||.||::.:|||||||||.:.|....::|:|:.|...|:|..
Zfish   510 KATLCSKKNCLQAIVAQLASDSEELQQVVSSILRNLSWRADINSKRALRDVGSVSGLMTCALQAT 574

  Fly   251 NENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSH 315
            .|:|||::||||||||||.:.||...|:|||||.|||..|:|...:.:|.|||:.|||||||||.
Zfish   575 KESTLKSVLSALWNLSAHSTENKVAICSVDGALGFLVSTLTYRCQTNSLAIIESGGGILRNVSSL 639

  Fly   316 IAVCEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAIPLLRAL 380
            ||..:.||||||.:|||..|||.|:|.|||:|||:||||||||||.|:||:.|.|..|:.:||.|
Zfish   640 IATRDDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSARSPKDQELLWDLGAVSMLRNL 704

  Fly   381 ISSKNSMIAEGSASALKNL-----VNFRATQELMPNGDGGSLPLDK--------EAGHGGTLPRR 432
            |:||:.|||.|||:||:||     :.::....:.|.....||.:.|        :|.|   |...
Zfish   705 INSKHKMIAMGSAAALRNLLTNRPLKYKDAAVISPGSCMPSLYMRKQKALEAELDAKH---LAET 766

  Fly   433 FSSLRLSS---------------------NPTGSLKKVRPSTVST---TG-------------FL 460
            |.:|...|                     :.:|.........|||   ||             ||
Zfish   767 FDTLEKQSFKHANINKPLRHIESLAKDYASDSGCFDDDEAPNVSTSLDTGTFSMLSMFLNNSNFL 831

  Fly   461 NRKCESRESIYSGKSDSTKYSTKSEGAKNPFEIVTPTEEQ----------PIDYSMKYMEHKPNS 515
            |.:...||.  ..:.|...:.|..:.::.|.:.||...|:          .||..:..:....:|
Zfish   832 NTQLRKREG--EPEQDIETFQTDIKRSQPPDDEVTVAAEKLAKKITNTVAKIDKLVDDITMHTSS 894

  Fly   516 SKTFEIDLDQ-----------------------PTDFSARY--KERRSAQTAQPELKSET----- 550
            ..:|.:..:.                       |...|:.:  |||.|...|...||:..
Zfish   895 EDSFSLSSEDHFLDWNYGPDELHEARAISCSPCPLSDSSTFSPKERLSRAHAFMRLKTTNSSLSN 959

  Fly   551 --------------------------------------------------------NEIRSKELQ 559
                                                                    |||..::.:
Zfish   960 DSLNSGSISDGYCGSQDQTHPSARPTEQRRPNKLDLKVAHEEPLTSGVHISRVLCQNEIPERDFE 1024

  Fly   560 LTK-------SSSATELRNSPGLVAVSAAKQKIATETETETA----------------------- 594
            ..|       .|:.||....|.:...:....|:::||...|.
Zfish  1025 ANKDAILPDSGSTDTEKSQEPFISTPATVSTKVSSETSIPTVKLSPSYQHVPLIQSVAKFGVAKT 1089

  Fly   595 ------------------------------------------ERPINYCEEGTPGSFSRFDSLNS 617
                                                      |.|..|..|.||..|||..||:|
Zfish  1090 AINVQAAQAMRRQAWVPAVMTGGSISKFSPICSARSPTIGQLETPQKYSVENTPICFSRCSSLSS 1154

  Fly   618 L-------------------------------------------------------TEKPEKCMP 627
            |                                                       |::......
Zfish  1155 LSSGDGALDGQSQTENELESDSSLEIIEVEDVNVERKDEEDENETLDDLSDSQLLVTDQKISSSD 1219

  Fly   628 PKTPTKT---------AVLPVHVDGNTP-QNIDSAL-ETPLMFSRRSSMDSLVGDDETVACEDNG 681
            |...:.|         .|.||.::..|| .:.|:.: ||||:.||.||:.|| |..|:.:..  .
Zfish  1220 PIEISGTIKNEKRFLRGVSPVILEDRTPSSSSDNYIHETPLVMSRCSSVSSL-GSFESPSIA--S 1281

  Fly   682 SVISE-YSRMQSGVISPSELPDSPTQSMPQSPRRDRK--------VSTQNNLDTPEQKPSTV--- 734
            |:.|: .|.|.||.:|||:|||||.|:||  |.|.:.        ...||......|..|::
Zfish  1282 SIQSDPCSEMISGTVSPSDLPDSPGQTMP--PSRSKTPCCPESGGADAQNLSGVGSQWESSLRKF 1344

  Fly   735 -----FEDKLN---------RFHVEHTPAAFSCATSLSNLSMMD-------DSNANAIRGQRGND 778
                 |:::.|         .|.||.....||||:|||.|.:.:       :.....:..|:.|
Zfish  1345 MEIADFKERFNLPQDLDTMIYFTVEKPIENFSCASSLSALPLHEHYVQKDVELKLTPLLNQQDN- 1408

  Fly   779 INGNGDAPRSYCTEDTTAVLSKAPSNSDLSIL------SIPNDLNANEAQPVPAPRADVTGMDTR 837
                 |...|...||.....|:..|:.|:.||      ::|:......:..:|:....|..|..|
Zfish  1409 -----DPEESEKEEDMEDQYSEGNSDDDIEILKECINSAMPSRFKKVRSTVIPSLSNQVINMQAR 1468

  Fly   838 ------MPAEDAISKMRCGGNAL-PSYLPVSDEMSKY--YVEDSPCTFSVISGL----------- 882
                  |..::..::| |.|..| .|...:..:.|.|  ..|.:|..||..:.|
Zfish  1469 KSVPVYMVLQNKNNQM-CTGQKLGMSSKEIYHDDSSYTDSAEGTPINFSSTTSLSDETLQYPART 1532

  Fly   883 -----------------------------------------SHLTVGS-----AKAGPVLKLPMR 901
                                                     |||....     .:..|..:|.::
Zfish  1533 KGMKDWRRNKETQELVDIEAKRIEDLRMFSRFHKPTKIACQSHLVTNQLNKTIRRMVPTQRLLIQ 1597

  Fly   902 TAEEAQAPKLPPRRSAVQGDAEPRLPPKKSDSLSSLSMDSDDDCNLLSQAIAAG--SC---RPQP 961
            :.|  .|.|:..:|  :|..:..|...|:..:||......|......|..:...  :|   ..|.
Zfish  1598 SKE--MAAKMTQQR--IQSQSPVRQIQKQGQNLSRSMPQLDFPMRKQSTEVYQNQKTCYLSHVQE 1658

  Fly   962 SGASTSSSLANASTSTLC----RENGQSKKQVEHGDKPNYSSDD-----SLDDDDDDARSKSLFE 1017
            :..|..|....:||..:|    |.:||..:.   |.|..|.|.:     ::.|..:..:|:.
Zfish  1659 NTLSLKSRRHPSSTEGICHKMERHDGQMNRT---GRKQQYDSSNIIRNANIQDQVNSYQSRQ--- 1717

  Fly  1018 QCILSGMHKSNDALESEGEPP 1038
                :|.|:....|..|..||
Zfish  1718 ----NGFHRIKQNLILEEAPP 1734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apc2	NP_001334699.1	None
apc2	XP_021335660.1	APC_N_CC	7..58	CDD:293294
		Suppressor_APC	156..233	CDD:314370
		armadillo repeat	459..502	CDD:293788	20/44 (45%)
		armadillo repeat	510..547	CDD:293788	14/36 (39%)
		armadillo repeat	556..589	CDD:293788	14/32 (44%)
		armadillo repeat	597..638	CDD:293788	23/40 (58%)
		Arm	644..683	CDD:278915	27/38 (71%)
		armadillo repeat	647..681	CDD:293788	24/33 (73%)
		Arm	685..723	CDD:278915	20/37 (54%)
		armadillo repeat	689..723	CDD:293788	18/33 (55%)
		Arm_APC_u3	726..981	CDD:318770	40/259 (15%)
		APC_r	1132..>1150	CDD:310482	9/17 (53%)
		SAMP	1427..1448	CDD:310483	5/20 (25%)
		APC_r	1501..1523	CDD:310482	7/21 (33%)
		APC_basic	1934..>2106	CDD:310501
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580922
Domainoid	1	1.000	198	1.000	Domainoid score	I3030
eggNOG	1	0.900	-	-		E1_KOG2122
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002986
OrthoInspector	1	1.000	-	-		mtm6551
orthoMCL	1	0.900	-	-		OOG6_105450
Panther	1	1.100	-	-	O	PTHR12607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2401
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730