DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc2 and APC

DIOPT Version :9

Sequence 1:NP_001334699.1 Gene:Apc2 / 42871 FlyBaseID:FBgn0026598 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_001341825.1 Gene:APC / 324 HGNCID:583 Length:2861 Species:Homo sapiens


Alignment Length:1654 Identity:432/1654 - (26%)
Similarity:611/1654 - (36%) Gaps:671/1654 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ELTRNFLELSRNPETCTALRSSDCIQLLVQILHANDE---------GLSTAKKYASQALHNIVHN 67
            :::|..|.:|.:.::|.::|.|.|:.||:|:||.||:         |...|:..||.|||||:|:
Human   329 DMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHS 393

  Fly    68 NPEEKERQREVKMLRLLDQILDYCNFLHTQLQSGGEAIADDEDRHPL---------AAMKLLMKA 123
            .|::|..:||:::|.||:||..||... .:.|...|. ..|:|::|:         .|:.:|||.
Human   394 QPDDKRGRREIRVLHLLEQIRAYCETC-WEWQEAHEP-GMDQDKNPMPAPVEHQICPAVCVLMKL 456

  Fly   124 SFDEEHRQTMCEL------------------GALKAIPNLVHLDHAVHGPAAGREQCNALRSYGL 170
            |||||||..|.||                  |.|:||..|:.:|..::| .........||.|..
Human   457 SFDEEHRHAMNELGRKATRGISSQELGQGLSGGLQAIAELLQVDCEMYG-LTNDHYSITLRRYAG 520

  Fly   171 MALTNLTFGDENVHNKSYLCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNE 235
            ||||||||||  |.||:.||..:..|..::|||.:..::|.||:|.||||||||||.:.|....|
Human   521 MALTNLTFGD--VANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLRE 583

  Fly   236 LGTVTSLARAAMQNKNENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLK 300
            :|:|.:|...|::.|.|:|||::|||||||||||:.|||:.||||||||||||.|:|...:.||.
Human   584 VGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLA 648

  Fly   301 IIENAGGILRNVSSHIAVCEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQ 365
            |||:.|||||||||.||..|.:|||||..|||..|||.|||.|||:|||:||||||||||.|:||
Human   649 IIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQ 713

  Fly   366 QYLIDHNAIPLLRALISSKNSMIAEGSASALKNLVNFRATQELMPN--GDGGSLP---------- 418
            :.|.|..|:.:|:.||.||:.|||.|||:||:||:..|..:....|  ..|.|||          
Human   714 EALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKAL 778

  Fly   419 ----------------------------------------------------------------- 418
                                                                             
Human   779 EAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPY 843

  Fly   419 --------------------------LDKEAGHG-----------GTLPRR-------------- 432
                                      |::|.|.|           ||..:|              
Human   844 LNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKV 908

  Fly   433 --------------------------------------------------FSSLRLSSNPTGSLK 447
                                                              .:|.|..|.|...|:
Human   909 MEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLE 973

  Fly   448 KVRPS-----TVSTTGFLNRKCESRESIYSGKSD------------------------------- 476
            ..|.|     :||::....::.:.:.||.|...|                               
Human   974 YKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGE 1038

  Fly   477 -------STKYST---------------------------------------------------- 482
                   |.|||.                                                    
Human  1039 LDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDK 1103

  Fly   483 -----------------KSEGA------------------------KNPFEIVTPT--------- 497
                             :|.||                        ::.:|...||         
Human  1104 HLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEE 1168

  Fly   498 -----EEQPIDYSMKYMEHKPNSSKTFEIDLDQPTDFSARY--------------KERRSAQTAQ 543
                 ||:|.:||:||.|.|.:        :|||.|:|.:|              .:..|.|:::
Human  1169 EQHEEEERPTNYSIKYNEEKRH--------VDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSK 1225

  Fly   544 PELKSETNEIRS-------KELQLTKSSSATELRNSPGLVAVSAAKQKIAT----ETETETAERP 597
            .|..|.::|..|       ::.||..||:.:.          |...||.||    ....||.:  
Human  1226 TEHMSSSSENTSTPSSNAKRQNQLHPSSAQSR----------SGQPQKAATCKVSSINQETIQ-- 1278

  Fly   598 INYCEEGTPGSFSRFDSLNSL----------------------------------------TEKP 622
             .||.|.||..|||..||:||                                        :|.|
Human  1279 -TYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVP 1342

  Fly   623 EKCMPPKTPTKT---------------------AVLPVHVDGNTPQNIDS--ALETPLMFSRRSS 664
            .....|:|.:..                     |..|......||::...  ..||||||||.:|
Human  1343 AVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTS 1407

  Fly   665 MDSLVG-DDETVACEDNGSVISE-YSRMQSGVISPSELPDSPTQSMPQSPRRDR-----KVSTQN 722
            :.||.. :..::|    .||.|| .|.|.||:||||:|||||.|:||  |.|.:     ..:.|.
Human  1408 VSSLDSFESRSIA----SSVQSEPCSGMVSGIISPSDLPDSPGQTMP--PSRSKTPPPPPQTAQT 1466

  Fly   723 NLDTPEQKPSTVFE-----------------------DKLNRFHVEHTPAAFSCATSLSNLSM-- 762
            ..:.|:.|..|..:                       |.|..|..|.||..|||::|||.||:  
Human  1467 KREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDE 1531

  Fly   763 ---------------MDDSNANAIRGQRGNDINGNGDAPRSYCTEDTTAVLSKAPSNSDLSIL-- 810
                           .::.|.|....::..:.|.|.: ..:..|.|:...|.....:.|:.||  
Human  1532 PFIQKDVELRIMPPVQENDNGNETESEQPKESNENQE-KEAEKTIDSEKDLLDDSDDDDIEILEE 1595

  Fly   811 ----SIPNDLN------ANEAQPVPAPRADVTGMDTRMPAEDAISKMRCGGNALP-----SYLPV 860
                ::|...:      |..|..:|.|.|       |.|::..:.|:....|.|.     |:.|.
Human  1596 CIISAMPTKSSRKAKKPAQTASKLPPPVA-------RKPSQLPVYKLLPSQNRLQPQKHVSFTPG 1653

  Fly   861 SDEMSKYYVEDSPCTFSVISGLSHLTV--------------GSAKAGPVLK---LPM--RTAEEA 906
            .|....|.||.:|..||..:.||.||:              |.|::|...|   :|.  |:.:||
Human  1654 DDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEA 1718

  Fly   907 QA--------PKLPPRRSAVQGD--AE---PRLPPKKSDSLSSLSMDSDDDCNLLSQAIAAGSC- 957
            |.        |:|...: |.:||  ||   ..:|..||.....:....|.    :.||.|:.|. 
Human  1719 QGGKTSSVTIPELDDNK-AEEGDILAECINSAMPKGKSHKPFRVKKIMDQ----VQQASASSSAP 1778

  Fly   958 ----------------RPQPSGA-------STSSSLANASTSTLCRENGQSKKQ-VEHGDK---- 994
                            :|.|...       ..:.|..|.:...:..:|..|||| :::..|    
Human  1779 NKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1843

  Fly   995 --PN--------------------------YSSDDSL-----DDDDDD-ARSKSLFEQCILSGMH 1025
              ||                          :|.:|||     ||||.| :|.|        :.:.
Human  1844 KLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREK--------AELR 1900

  Fly  1026 KSNDALESEGEPPGQRQEISARDRFVSNQ 1054
            |:.:..|||.       ::::.....|||
Human  1901 KAKENKESEA-------KVTSHTELTSNQ 1922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Apc2NP_001334699.1 None
APCNP_001341825.1 SMC_N <4..272 CDD:330553
APC_N_CC 4..55 CDD:293294
Suppressor_APC 127..207 CDD:314370
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..305
ARM 340..392 CDD:214547 20/51 (39%)
armadillo repeat 490..526 CDD:293788 13/36 (36%)
ARM 2 523..565 21/43 (49%)
ARM 530..571 CDD:214547 19/42 (45%)
armadillo repeat 534..571 CDD:293788 16/36 (44%)
ARM 3 566..609 21/42 (50%)
armadillo repeat 581..613 CDD:293788 15/31 (48%)
ARM 4 610..656 31/45 (69%)
armadillo repeat 621..662 CDD:293788 28/40 (70%)
ARM 5 657..701 30/43 (70%)
ARM 667..707 CDD:214547 28/39 (72%)
armadillo repeat 671..705 CDD:293788 25/33 (76%)
ARM 6 702..743 24/40 (60%)
Arm 709..749 CDD:278915 21/39 (54%)
armadillo repeat 713..749 CDD:293788 19/35 (54%)
ARM 7 744..785 9/40 (23%)
Arm_APC_u3 750..1036 CDD:318770 26/285 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 846..896 7/49 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 941..961 0/19 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 976..1005 7/28 (25%)
Responsible for down-regulation through a process mediated by direct ubiquitination 978..1355 65/397 (16%)
APC_u5 1054..1153 CDD:318771 3/98 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1187 13/69 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1208..1262 11/63 (17%)
APC_r 1275..>1292 CDD:310482 9/19 (47%)
APC_u9 1301..1386 CDD:318774 6/84 (7%)
DUF4045 <1309..1719 CDD:330572 101/423 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1329..1394 8/64 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1421..1493 26/73 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1544..1587 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1629 8/34 (24%)
APC_r 1655..1678 CDD:310482 9/22 (41%)
APC_u13 1680..1733 CDD:318775 11/52 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1682..1735 11/52 (21%)
SAMP 1734..1755 CDD:310483 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1747..1854 20/110 (18%)
APC_u14 1764..1857 CDD:318776 17/96 (18%)
Highly charged 1884..1911 11/41 (27%)
APC_u15 1891..1965 CDD:318777 10/47 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1899..1968 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1983..2029
SAMP 2051..2070 CDD:310483
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2061..2090
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2165..2653
APC_basic 2241..2586 CDD:310501
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2685..2732
EB1_binding 2688..2861 CDD:310490
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2747..2861
Microtubule tip localization signal 2821..2824
PDZ-binding 2859..2861
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147383
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm8653
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - O PTHR12607
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2401
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.770

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