DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc2 and Apc2

DIOPT Version :10

Sequence 1:NP_477430.1 Gene:Apc2 / 42871 FlyBaseID:FBgn0026598 Length:1067 Species:Drosophila melanogaster
Sequence 2:XP_038934575.1 Gene:Apc2 / 299611 RGDID:1308256 Length:2315 Species:Rattus norvegicus


Alignment Length:1357 Identity:374/1357 - (27%)
Similarity:538/1357 - (39%) Gaps:416/1357 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ATR--LELTRNFLELSRNPETCTALRSSDCIQLLVQILHAND------------EGLSTAKKYAS 58
            |||  .:..|..|.:|.:||:|.|:|.|.|:.||:||||..:            .|...|:..|:
  Rat   317 ATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRTGTPGAPGAKDARMRAN 381

  Fly    59 QALHNIVHNNPEEKERQREVKMLRLLDQILDYCNFLHTQLQ---SGGEAIADDE----DRHPLAA 116
            .||||||.:.|::...::|:::|.:|:||..||......||   ||.|:...|.    :.....|
  Rat   382 AALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQA 446

  Fly   117 MKLLMKASFDEEHRQTMCELGALKAIPNLVHLDHAVHGPAAGREQCN-ALRSYGLMALTNLTFGD 180
            ...:||.|||||:|:.|.|||.|:|:..|:.:|:.:|  ...::..| |||.|..|.||||||||
  Rat   447 ACAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMH--KMTQDPLNLALRRYAGMTLTNLTFGD 509

  Fly   181 ENVHNKSYLCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLARA 245
              |.||:.||.:|..||.::|||.:..:||.||::.:|||||||||.:.|.:..|:|::|:|...
  Rat   510 --VANKATLCARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMEC 572

  Fly   246 AMQNKNENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILR 310
            .::...|:|||::||||||||||.:.|||..|.|||||.|||..|:|.....:|.:||:.|||||
  Rat   573 VLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILR 637

  Fly   311 NVSSHIAVCEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAIP 375
            ||||.||..|.|||:||.:|||..|||.|.|.|||:|||:||||||||||.|.||:.|.|..|:.
  Rat   638 NVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVG 702

  Fly   376 LLRALISSKNSMIAEGSASALKNLVNFRA--------------------------------TQEL 408
            :||.|:.||:.|||.|||:||:||:..|.                                |:.|
  Rat   703 MLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHL 767

  Fly   409 M---------------------------------------------------------------- 409
            :                                                                
  Rat   768 VHALGHLEKQGLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAV 832

  Fly   410 ------------------PNGDGGSLPLDKEAGHGGTLPRR------------------FSSLRL 438
                              |....|.|..:||.|....:..:                  .|:|..
  Rat   833 MSMFLGGPFLQGQALARTPPARQGGLEAEKETGGEAAVAAKAKAKLALAVARIDRLVEDISALHT 897

  Fly   439 SSNPTGSLKKVRPSTVSTTGFLNRKCE-----------------------------SRESIYSGK 474
            ||:.:.||....|...:......:.|.                             |.:|:.|| 
  Rat   898 SSDDSFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSG- 961

  Fly   475 SDSTKYSTKSEGAKNPFEIVTPTEEQPIDYSMKYMEHKPNSSKTFEIDLDQPTDFSARYKERRSA 539
            |.|..|.|:......|..::|...:.|:          ...::...:|||.|:  .|....|.:|
  Rat   962 STSDGYCTREHMTPCPLAVLTEHRDGPV----------CGQTRPSRLDLDLPS--RAELPARDTA 1014

  Fly   540 QTAQPELKSETNEIRSKELQLTKSSSATELRN-SPG-----LVAVSAA----KQK-IATETETET 593
            .|          :.|.:.::|:.:.....|.: :||     ||.:..:    ||. |..::.::.
  Rat  1015 AT----------DARVRTIKLSPTYQHVPLLDGAPGAGVRPLVGLGTSPGTRKQAWIPADSLSKV 1069

  Fly   594 AER------PIN-------YCEEGTPGSFSRFDSLNSLT--------------------EKPEKC 625
            .|:      |:.       ..::| |.|.||..||:||:                    |:.|:.
  Rat  1070 PEKLVASPLPVTSKVLQKLVAQDG-PMSLSRCSSLSSLSSTGHAVPSQVENLDDSDSSLEELEEA 1133

  Fly   626 MPPKTPTKTA-------VLPVH-------------VDGNTPQNI--DSALETPLMFSRRSSMDSL 668
            .|.:.....|       .|||.             |:..||.:.  :...||||:.||.||:.||
  Rat  1134 GPGEAELDRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSL 1198

  Fly   669 VG-DDETVACEDNGSVISE-YSRMQSGVISPSELPDSPTQSMPQSPRRDR------------KVS 719
            .. :..::|    .|:.|: .|.:.||.:|||||||||.|:||  |.|.|            :.|
  Rat  1199 GSFESRSIA----SSIPSDPCSALGSGTVSPSELPDSPGQTMP--PSRSRTPPAPPGQPEASQFS 1257

  Fly   720 TQ------NNLDTPE-----QKPSTVFEDKLNRFHVEHTPAAFSCATSLSNLSMMDDSNANAIRG 773
            .|      ..||..:     |.||.:....: ||.||.....||||:|||.|::.:         
  Rat  1258 LQWESYVKRFLDIADCRERCQPPSELDAGSV-RFTVEKPDENFSCASSLSALALHE--------- 1312

  Fly   774 QRGNDINGNGDAPRSYCTEDTTAVLSKAPSNSDLSILSIPNDLNANEAQ-----PVPAPRADVTG 833
                          .|..:|....| :.|:..:.::.........:||.     |.||      |
  Rat  1313 --------------LYVQQDVELRL-RPPACPERAVGGGGGHRRRDEATSRLDGPAPA------G 1356

  Fly   834 MDTRMPAEDAISKMR-CGGNALPSYL----------------PV---------SDEMSKYYVEDS 872
            ...|..|:..:..:| |.|.|:|:.|                ||         .|:......|.:
  Rat  1357 SRARSAADKELEALRECLGAAMPARLRKVASALVPGRRALPVPVYMLVPAPARGDDSGTDSAEGT 1421

  Fly   873 PCTFSVISGLSHLTVGSAKAGPVLKLPMRTAEEAQAPKLPPRRSAVQGDAEPRLP-----PKKSD 932
            |..||..:.||..|:    .||....|.|          |..|....|.|.|...     ||.:.
  Rat  1422 PVNFSSAASLSDETL----QGPSRDKPAR----------PGDRQKPTGRAAPARQTRGHRPKAAG 1472

  Fly   933 SLSSLSMDSDDDCNLLSQAIAAGSCRPQPSGASTSSSLANASTSTLCRENGQSKKQ-------VE 990
            :.:..|.:.....|.....:.....|||       |:.:|...|...|..|....|       .|
  Rat  1473 AGAGKSTEHTRGANRNRAGLELPLSRPQ-------SARSNRDGSCQTRTRGDGALQSLCLTTPTE 1530

  Fly   991 HGDKPNYSSDDSLDDDDDDARSKSLFEQCILSGMHKSNDALESEGEPPGQRQEISAR 1047
            ......|.||:.........|..|...:.:             :.|.|..|:|...|
  Rat  1531 EAVYCFYDSDEEPPATAPPTRRASAIPRAL-------------KREKPAGRKETPTR 1574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Apc2NP_477430.1 ARM 23..66 CDD:214547 21/54 (39%)
armadillo repeat 29..64 CDD:293788 16/46 (35%)
APC_rep 69..133 CDD:465870 23/70 (33%)
armadillo repeat 72..124 CDD:293788 16/58 (28%)
armadillo repeat 139..176 CDD:293788 13/37 (35%)
armadillo repeat 186..223 CDD:293788 17/36 (47%)
armadillo repeat 273..314 CDD:293788 23/40 (58%)
Arm 319..359 CDD:425727 27/39 (69%)
armadillo repeat 323..357 CDD:293788 23/33 (70%)
Arm 361..400 CDD:425727 20/38 (53%)
armadillo repeat 365..399 CDD:293788 17/33 (52%)
APC_15aa 497..511 CDD:461790 1/13 (8%)
APC_r 596..618 CDD:461781 8/34 (24%)
APC_r 737..760 CDD:461781 11/22 (50%)
APC_r 784..807 CDD:461781 4/22 (18%)
Apc2XP_038934575.1 APC_N_CC 34..85 CDD:435517
Suppressor_APC 152..239 CDD:463275
APC_rep 390..463 CDD:465870 29/79 (37%)
armadillo repeat 462..505 CDD:293788 21/43 (49%)
armadillo repeat 513..550 CDD:293788 16/36 (44%)
armadillo repeat 559..592 CDD:293788 21/32 (66%)
armadillo repeat 600..641 CDD:293788 22/40 (55%)
Arm 647..686 CDD:425727 24/38 (63%)
armadillo repeat 650..684 CDD:293788 23/33 (70%)
Arm 688..728 CDD:425727 19/153 (12%)
armadillo repeat 692..728 CDD:293788 18/149 (12%)
Arm_APC_u3 729..975 CDD:435476 69/358 (19%)
APC_r 1175..1198 CDD:461781 7/22 (32%)
APC_r 1287..1308 CDD:461781 5/27 (19%)
APC_r 1411..1433 CDD:461781
PHA03247 <1538..1963 CDD:223021
SAMP 1632..1653 CDD:461782
APC_basic 1798..2130 CDD:428690
DUF5585 <2075..>2314 CDD:465521
Blue background indicates that the domain is not in the aligned region.

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