DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc2 and Apc

DIOPT Version :10

Sequence 1:NP_477430.1 Gene:Apc2 / 42871 FlyBaseID:FBgn0026598 Length:1067 Species:Drosophila melanogaster
Sequence 2:NP_036631.1 Gene:Apc / 24205 RGDID:2123 Length:2842 Species:Rattus norvegicus


Alignment Length:1611 Identity:428/1611 - (26%)
Similarity:605/1611 - (37%) Gaps:606/1611 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ELTRNFLELSRNPETCTALRSSDCIQLLVQILHANDE---------GLSTAKKYASQALHNIVHN 67
            :::|..|.:|.:.::|.::|.|.|:.||:|:||.||:         |...|:..||.|||||:|:
  Rat   327 DMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHS 391

  Fly    68 NPEEKERQREVKMLRLLDQILDYCNFLHTQLQSGGEAIADDEDRHPL---------AAMKLLMKA 123
            .|::|..:||:::|.||:||..||.......::..:.:  |:|::|:         .|:.:|||.
  Rat   392 QPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGM--DQDKNPMPAPVEHQICPAVCVLMKL 454

  Fly   124 SFDEEHRQTMCELGALKAIPNLVHLDHAVHGPAAGREQCNALRSYGLMALTNLTFGDENVHNKSY 188
            |||||||..|.|||.|:||..|:.:|..:|| .........||.|..||||||||||  |.||:.
  Rat   455 SFDEEHRHAMNELGGLQAIAELLQVDCEMHG-LTDDHYSVTLRRYAGMALTNLTFGD--VANKAT 516

  Fly   189 LCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLARAAMQNKNEN 253
            ||..:..|..::|||.:..::|.||:|.||||||||||.:.|....|:|:|.:|...|::.|.|:
  Rat   517 LCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKES 581

  Fly   254 TLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGILRNVSSHIAV 318
            |||::|||||||||||:.|||:.||||||||||||.|:|...:.||.|||:.|||||||||.||.
  Rat   582 TLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIAT 646

  Fly   319 CEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAIPLLRALISS 383
            .|.:|||||..|||..|||.|||.|||:|||:||||||||||.|:||:.|.|..|:.:|:.||.|
  Rat   647 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHS 711

  Fly   384 KNSMIAEGSASALKNLVNFRATQELMPN--GDGGSLP-------------LDKE----------- 422
            |:.|||.|||:||:||:..|..:....|  ..|.|||             ||.:           
  Rat   712 KHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDN 776

  Fly   423 -------------------------AGHGGTLPRRFSS--------------LRLSSNPTGSLKK 448
                                     :.|.......|::              |..||:..|||..
  Rat   777 LSPKASHRSKQRHKQNLYGDYVFDASRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDS 841

  Fly   449 VR------------------------PSTVSTTGF------------------------------ 459
            .|                        |.|.|..|.                              
  Rat   842 SRSEKDRSLERERGIGLSTYHSATENPGTSSKRGLQLSATAAQIAKVMEEVSALHTSQDDRSPAS 906

  Fly   460 ----------------------------------LNRKC-----------ESRESIYS------- 472
                                              .||.|           .|.:|:.|       
  Rat   907 AAELHCVAEERTAARRSSASHTHPNTHNFAKSESSNRTCSMPYAKVEYKRSSNDSLNSVTSSDGY 971

  Fly   473 GKSDSTK-----YSTKSEG-----AKNPFEIVTPTE------------EQPIDYSMKYMEHKPNS 515
            ||....|     ||...||     .:.|.::.....            :.||:||:||.:.:.||
  Rat   972 GKRGQMKPSVESYSEDDEGKFCSYGQYPADLAHKIHSANHMDDNGGELDTPINYSLKYSDEQLNS 1036

  Fly   516 SK---------------------------------TFEI-------------------------- 521
            .:                                 .|.:                          
  Rat  1037 GRQSPSQNERWARPKHVIEDEIKQNEQRQSRSQNTNFPVYSENTDDKHLKFQQHFGQQECVSPYR 1101

  Fly   522 --------------------------------DLDQPTDFSARYKERRSAQ-------------- 540
                                            :.|:||::|.||.|....:              
  Rat  1102 SRGTNGSETNRMGSSHAVNQNVNQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNE 1166

  Fly   541 ----TAQP---ELKSETNEIRSKE--LQLTKSSSA----TELRNSPGLVAVSA--AKQKIATETE 590
                ..||   .||..|:...|::  ...:|:.|.    || .|||...|.||  :..|..::..
  Rat  1167 EKHHVDQPIDYSLKYATDISSSQKPSFSFSKTPSVQGTKTE-HNSPSSEAASAPSSNAKRQSQLH 1230

  Fly   591 TETAER-------------PIN------YCEEGTPGSFSRFDSLNSLT----------------- 619
            ..:|:|             .||      ||.|.||..|||..||:||:                 
  Rat  1231 PSSAQRNGQTPKGTACKVPSINQETMQTYCVEDTPICFSRCSSLSSLSSAEDEIGCDQTTQEADS 1295

  Fly   620 ------------------EKPEKCMP---PKTPTKTAVL-----------------------PVH 640
                              :.|...:|   ..|.||.:.|                       |..
  Rat  1296 ANTLQIAEIKENDVTRSAQDPASDVPAVSQSTRTKPSRLQASGLASESARHKAVEFSSGAKSPSK 1360

  Fly   641 VDGNTPQNIDS--ALETPLMFSRRSSMDSLVG-DDETVACEDNGSVISE-YSRMQSGVISPSELP 701
            ....||::...  ..||||:|||.:|:.||.. :..::|    .||.|| .|.|.||::|||:||
  Rat  1361 SGAQTPKSPPEHYVQETPLVFSRCTSVSSLDSFESRSIA----SSVQSEPCSGMVSGIVSPSDLP 1421

  Fly   702 DSPTQSMPQS-------PRRDRKVSTQNNLDTPEQKPSTVFE----------------------- 736
            |||.|:||.|       |...:.|.|:.  :.|:.|.....:                       
  Rat  1422 DSPGQTMPPSRSKTPPPPPPPQPVQTKR--EVPKTKVPAAEQREGGPKQTAVSAAVQRVQVLPDA 1484

  Fly   737 DKLNRFHVEHTPAAFSCATSLSNLSM-----------------MDDSNANAIRGQRGNDINGNGD 784
            |.|..|..|.||..|||::|||.||:                 .::.|.|....::..:.|.|.|
  Rat  1485 DTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETEPEQPEESNENQD 1549

  Fly   785 APRSYCTEDTTAVLSKAPSNSDLSIL------SIPNDLN------ANEAQPVPAPRADVTGMDTR 837
              :.....|:...|.....:.|:.||      ::|...:      |..|..:|.|.|       |
  Rat  1550 --KEVEKPDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVA-------R 1605

  Fly   838 MPAEDAISKM-----RCGGNALPSYLPVSDEMSKYYVEDSPCTFSVISGLSHLTVGS----AKAG 893
            .|::..:.|:     |.......|:.|..|....|.||.:|..||..:.||.||:.|    ..||
  Rat  1606 KPSQLPVYKLLPSQSRLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELAAG 1670

  Fly   894 PVLKLPMRTAEEAQAPKLP--------PRRSAVQGDAEPRLPPKKSDSLSSLS------------ 938
            ..::..:::.|..:...:|        .:|..|...|.|.|...|::....|:            
  Rat  1671 DGVRASVQSGEFEKRDTIPTEGRSTDEAQRGKVSSIAIPDLDGSKAEEGDILAECINSALPKGRS 1735

  Fly   939 ---------MDSDDDCNLLSQAI-----------AAGSCRPQPSGA-------STSSSLANASTS 976
                     ||.....::.|...           .....:|.|...       ..:.|..|.:|.
  Rat  1736 HKPFRVKKIMDQVQQASMTSSGTNKNQIDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTE 1800

  Fly   977 TLCRENGQSKKQ-------------------VEHG---DKPN-----------YSSDDSL----- 1003
            ....:|..||||                   |..|   |.|:           :|.:|||     
  Rat  1801 ETFSDNKDSKKQSLKNNPKDLNDKLPDNEDRVRGGFTFDSPHHYAPIEGTPYCFSRNDSLSSLDF 1865

  Fly  1004 DDDDDD-ARSKSLFEQCILSGMHKSNDALESEG------EPPGQRQEISAR 1047
            ||||.| :|.|        :.:.|..::.:||.      ||...:|  |||
  Rat  1866 DDDDVDLSREK--------AELRKGKESKDSEAKVTCHTEPSSSQQ--SAR 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Apc2NP_477430.1 ARM 23..66 CDD:214547 20/51 (39%)
armadillo repeat 29..64 CDD:293788 17/43 (40%)
APC_rep 69..133 CDD:465870 25/72 (35%)
armadillo repeat 72..124 CDD:293788 17/60 (28%)
armadillo repeat 139..176 CDD:293788 14/36 (39%)
armadillo repeat 186..223 CDD:293788 16/36 (44%)
armadillo repeat 273..314 CDD:293788 28/40 (70%)
Arm 319..359 CDD:425727 28/39 (72%)
armadillo repeat 323..357 CDD:293788 25/33 (76%)
Arm 361..400 CDD:425727 20/38 (53%)
armadillo repeat 365..399 CDD:293788 17/33 (52%)
APC_15aa 497..511 CDD:461790 6/25 (24%)
APC_r 596..618 CDD:461781 13/40 (33%)
APC_r 737..760 CDD:461781 12/22 (55%)
APC_r 784..807 CDD:461781 3/22 (14%)
ApcNP_036631.1 APC_N_CC 4..55 CDD:435517
SMC_prok_B <22..>311 CDD:274008
Suppressor_APC 125..205 CDD:463275
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..304
ARM 338..390 CDD:214547 20/51 (39%)
APC_rep 391..464 CDD:465870 25/74 (34%)
ARM 1 451..493 21/42 (50%)
ARM 457..508 CDD:214547 25/51 (49%)
armadillo repeat 463..506 CDD:293788 18/43 (42%)
ARM 2 503..545 21/43 (49%)
ARM 510..551 CDD:214547 19/42 (45%)
armadillo repeat 514..551 CDD:293788 16/36 (44%)
ARM 3 546..589 21/42 (50%)
armadillo repeat 558..593 CDD:293788 16/34 (47%)
ARM 4 590..636 31/45 (69%)
armadillo repeat 601..642 CDD:293788 28/40 (70%)
ARM 5 637..681 30/43 (70%)
ARM 647..687 CDD:214547 28/39 (72%)
armadillo repeat 651..685 CDD:293788 25/33 (76%)
ARM 6 682..723 24/40 (60%)
Arm 689..729 CDD:425727 21/39 (54%)
armadillo repeat 693..729 CDD:293788 19/35 (54%)
ARM 7 724..765 11/40 (28%)
Arm_APC_u3 730..1017 CDD:435476 35/286 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 828..877 11/48 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 921..942 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 956..988 8/31 (26%)
Interaction with catenins. /evidence=ECO:0000250|UniProtKB:P25054 1018..1167 16/148 (11%)
APC_u5 1034..1133 CDD:406923 3/98 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1058..1078 1/19 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1092..1166 7/73 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1188..1249 14/61 (23%)
APC_r 1254..>1271 CDD:461781 7/16 (44%)
APC_u9 1280..1365 CDD:435478 7/84 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1306..1373 9/66 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1398..1474 26/81 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1525..1568 7/44 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1584..1609 7/31 (23%)
APC_r 1635..1658 CDD:461781 9/22 (41%)
APC_u13 1660..1712 CDD:406927 9/51 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1711 9/49 (18%)
SAMP 1714..1735 CDD:461782 2/20 (10%)
APC_u14 1744..1837 CDD:435479 15/92 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1748..1950 35/169 (21%)
Highly charged 1864..1891 10/34 (29%)
APC_u15 1871..1945 CDD:435480 12/46 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1963..2010
SAMP 2032..2051 CDD:461782
Interaction with AXIN1. /evidence=ECO:0000250|UniProtKB:P25054 2034..2058
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2043..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2148..2173
Basic region. /evidence=ECO:0000250|UniProtKB:P25054 2167..2674
APC_basic 2223..2568 CDD:428690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2234..2641
Interaction with DLG1. /evidence=ECO:0000250|UniProtKB:P25054 2475..2842
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2664..2842
EB1_binding 2670..2842 CDD:399141
Interaction with MAPRE1. /evidence=ECO:0000250|UniProtKB:P25054 2674..2842
Microtubule tip localization signal 2802..2805
PDZ-binding. /evidence=ECO:0000250 2840..2842
Blue background indicates that the domain is not in the aligned region.

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