Protein Alignment ATXN3 and Atxn3

DIOPT Version :10

• Sequence 1: NP_001410999.1
• Gene: ATXN3 / 4287
• HGNCID: 7106
• Length: 375
• Species: Homo sapiens
• Sequence 2: XP_006240547.1
• Gene: Atxn3 / 60331
• RGDID: 621567
• Length: 382
• Species: Rattus norvegicus
• Alignment Length: 403
• Identity: 308/403 - (76%)
• Similarity: 326/403 - (80%)
• Gaps: 49/403 - (12%)

Human     1 MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQP 65
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
  Rat     1 MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERLRMAEGGVTSEDYRTFLQQP 65

Human    66 SGNMDDSGFFSIQ---------------------------VISNALKVWGLELILFNSPEYQRLR 103
            |||||||||||||                           |||||||||||||||||||||||||
  Rat    66 SGNMDDSGFFSIQSPYSLAFPPRTSLVHLGRPSGPELRAEVISNALKVWGLELILFNSPEYQRLR 130

Human   104 IDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGD 168
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 IDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGD 195

Human   169 LPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRAL 233
            |||||||||||||:|||||||||||||||.||||...|.||||||||.||.||.|:||:||||||
  Rat   196 LPDCEADQLLQMIKVQQMHRPKLIGEELAHLKEQSALKADLERVLEAADGPGMFDDDEDDLQRAL 260

Human   234 ALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQ 298
            |:|||||||||||||||||||||||||||.:.:|..|||.|:|:||||||||||||||
  Rat   261 AMSRQEIDMEDEEADLRRAIQLSMQGSSRGMCEDSPQTSSTDLSSEELRKRREAYFEK------- 318

Human   299 QQQQQQQQQQQQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSD-LGDAMSEEDMLQAAVTMSL 362
                          ||.|||:.|..|..|:|||||.||||.|.|: .|:||||||:|:|.||:||
  Rat   319 --------------QQHQQQEADRPGYLSYPCERPTTSSGGLRSNQAGNAMSEEDVLRATVTVSL 369

Human   363 ETVRNDLKTEGKK 375
            ||.::.||.|.||
  Rat   370 ETAKDSLKAERKK 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN3	NP_001410999.1	Josephin	9..163	CDD:460444	152/180 (84%)
		SUIM_assoc	263..343	CDD:465203	38/79 (48%)
Atxn3	XP_006240547.1	Josephin	9..190	CDD:460444	152/180 (84%)
		SUIM_assoc	291..349	CDD:465203	38/78 (49%)