DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATXN3 and CG3781

DIOPT Version :9

Sequence 1:	NP_004984.2	Gene:	ATXN3 / 4287	HGNCID:	7106	Length:	361	Species:	Homo sapiens
Sequence 2:	NP_572303.4	Gene:	CG3781 / 31560	FlyBaseID:	FBgn0029853	Length:	221	Species:	Drosophila melanogaster

Alignment Length:	198	Identity:	53/198 - (26%)
Similarity:	79/198 - (39%)	Gaps:	57/198 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     4 IFHEKQEGSLCAQHCLNNLLQG-EYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQ---- 63
            |:||:|...||..|.||||.|| :.||..||                      :||.|.|.
  Fly    39 IYHERQTRHLCGLHALNNLFQGPDMFSKSEL----------------------DDYCTTLTPRNW 81

Human    64 -QPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDP--INER---SFICN------- 115
             .|..:....|.:.:.||..||:....|.:.|:.      |.||  :|..   .||.|
  Fly    82 LNPHRSWIGWGNYDVNVIMYALQQRNCEAVWFDR------RRDPHCLNLSVIFGFILNVPAQMSL 140

Human   116 --------YKEHWFTVRKLGKQWFNLNSLLTGPELI--SDTYLALFLAQLQQEGYSIFVVKGDLP 170
                    :..||..:|:|...::||:|.|..|:.:  ...:|.....|||.: :.:|:|..:..
  Fly   141 GYYIPLPFHMRHWLALRRLNGSYYNLDSKLREPKCLGTEQQFLEFLATQLQMD-HELFLVLDEET 204

Human   171 DCE 173
            ||:
  Fly   205 DCK 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN3	NP_004984.2	Josephin	11..163	CDD:307972	45/179 (25%)
		SUIM_assoc	264..328	CDD:318760
		polyglutamine repeat	292..305
CG3781	NP_572303.4	Josephin	44..184	CDD:280299	42/167 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1482722at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920