DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1d7 and Tbc1d7

DIOPT Version :9

Sequence 1:	NP_651223.2	Gene:	TBC1d7 / 42869	FlyBaseID:	FBgn0039158	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_001239568.1	Gene:	Tbc1d7 / 67046	MGIID:	1914296	Length:	293	Species:	Mus musculus

Alignment Length:	293	Identity:	94/293 - (32%)
Similarity:	159/293 - (54%)	Gaps:	18/293 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TD--ERNFRSIYYEKCQINSVEEQKSLNKLLQDDIRNLSKLKQFCMNYTVPNNNRSYLWALVMGI 65
            ||  :|||||:||||.....|||:|||..||:||..::.||..|...:.:|:..|:.:|..::||
Mouse     2 TDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGI 66

  Fly    66 LPLHKASTAYVRDQRREMYEDLRRAVTVLRFTDHKQKEQPFMWLIDHKKKAQVMHTMWLIESNRL 130
            ||.|..:.:.|...|::.|.|:..|:||:||            :.|...:|:|...|:.:||.:|
Mouse    67 LPPHHDTHSQVMAYRKDQYHDILHALTVVRF------------ISDATPQAEVYLRMYQLESGKL 119

  Fly   131 WHGNTSASLQADDMHFIEIVRTLLQIFDDNVETYWIAKGFYKYTRELKKECV-KLKEQTQNILKR 194
             ..:.|..|:.:|..|:.|.:.:.::.:|:|:.|||::.|.|......::.: :|.:..:..|..
Mouse   120 -PRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNL 183

  Fly   195 EDLSLLNHLELLGLFDGNSTLLDNWYITCFAGIICTTHLVKIWDKVCGGSRKIVVFLFVELVKDI 259
            ||..||:||:.....  :....|.|:..||||.:..:.|.::||||..||.||:||:.||::...
Mouse   184 EDSRLLSHLKTCSAV--SKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTF 246

  Fly   260 RSSILKQTSLADVKRLIETVKDLDGVIIVNKAI 292
            :..::...|...:.:.:|.:.......||:|||
Mouse   247 KIKVMALNSAEKITKFLENIPQDSSDAIVSKAI 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1d7	NP_651223.2	None
Tbc1d7	NP_001239568.1	RabGAP-TBC	<147..247	CDD:295329	34/101 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CM5X
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9538
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4285
Isobase	1	0.950	-	0	Normalized mean entropy	S7099
OMA	1	1.010	-	-		QHG52857
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008411
OrthoInspector	1	1.000	-	-		oto95424
orthoMCL	1	0.900	-	-		OOG6_107388
Panther	1	1.100	-	-	LDO	PTHR13530
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5358
SonicParanoid	1	1.000	-	-		X6401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740