DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1d7 and TBC1D7

DIOPT Version :9

Sequence 1:	NP_651223.2	Gene:	TBC1d7 / 42869	FlyBaseID:	FBgn0039158	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_001137436.1	Gene:	TBC1D7 / 51256	HGNCID:	21066	Length:	293	Species:	Homo sapiens

Alignment Length:	293	Identity:	99/293 - (33%)
Similarity:	153/293 - (52%)	Gaps:	24/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERNFRSIYYEKCQINSVEEQKSLNKLLQDDIRNLSKLKQFCMNYTVPNNNRSYLWALVMGILPLH 69
            :|||||:||||.....|||:|||..||:||..:..||..|...:.:|:..|:.:|.:::||||.|
Human     6 QRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPSMYRALVWKVLLGILPPH 70

  Fly    70 KASTAYVRDQRREMYEDLRRAVTVLRFTDHKQKEQPFMWLIDHKKKAQVMHTMWLIESNRLWHGN 134
            ..|.|.|...|:|.|.|:..|:.|:||..            |...:|:|...|:.:||.:| ..:
Human    71 HESHAKVMMYRKEQYLDVLHALKVVRFVS------------DATPQAEVYLRMYQLESGKL-PRS 122

  Fly   135 TSASLQADDMHFIEIVRTLLQIFDDNVETYWIAKGFY-----KYTRELKKECVKLKEQTQNILKR 194
            .|..|:.||..|:.|.:.:.::.:|:|:.|||.:.|.     || |:...:..|..||..|:
Human   123 PSFPLEPDDEVFLAIAKAMEEMVEDSVDCYWITRRFVNQLNTKY-RDSLPQLPKAFEQYLNL--- 183

  Fly   195 EDLSLLNHLELLGLFDGNSTLLDNWYITCFAGIICTTHLVKIWDKVCGGSRKIVVFLFVELVKDI 259
            ||..||.||.:...  ......|.|:..||||.:..:.|.::||||..||.||:||:.||::...
Human   184 EDGRLLTHLRMCSA--APKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTF 246

  Fly   260 RSSILKQTSLADVKRLIETVKDLDGVIIVNKAI 292
            :..::...|...:.:.:|.:.......||:|||
Human   247 KIKVMALNSAEKITKFLENIPQDSSDAIVSKAI 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1d7	NP_651223.2	None
TBC1D7	NP_001137436.1	RabGAP-TBC	<147..251	CDD:321955	38/109 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9538
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4353
Isobase	1	0.950	-	0	Normalized mean entropy	S7099
OMA	1	1.010	-	-		QHG52857
OrthoDB	1	1.010	-	-		D1440539at2759
OrthoFinder	1	1.000	-	-		FOG0008411
OrthoInspector	1	1.000	-	-		oto91845
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13530
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.990