DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6178 and PCS60

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_009781.3	Gene:	PCS60 / 852523	SGDID:	S000000426	Length:	543	Species:	Saccharomyces cerevisiae

Alignment Length:	500	Identity:	137/500 - (27%)
Similarity:	241/500 - (48%)	Gaps:	44/500 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VKQNDVVGLSSENSVNFALAMFAGLAVGATV-APLNVTYSDREVDHAINLSKPKIIF----ASKI 133
            |.:.|.|.:|..|.:.|.:| |.|..:.|.: ||||..|.::|.:..:|..|.|.|.    .:|:
Yeast    59 VFRQDTVAISMRNGLEFIVA-FLGATMDAKIGAPLNPNYKEKEFNFYLNDLKSKAICVPKGTTKL 122

  Fly   134 TIDRVAKVASKNKFVKGIIALSGTSKKFKNIYDL-------KEL----MEDEKFKTQPDFTSPAA 187
            ....:.|.||  .|...|:.|:..:.:|:..||:       |.:    :.:.||........|..
Yeast   123 QSSEILKSAS--TFGCFIVELAFDATRFRVEYDIYSPEDNYKRVIYRSLNNAKFVNTNPVKFPGF 185

  Fly   188 NKDEDVSLIVCSSGTTGLPKGVQLTQMNLL-ATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCL-T 250
            .:..||:||:.:||||..||.|.|..:|:: :||:......:.|::.  ...|:|.||..|.: .
Yeast   186 ARSSDVALILHTSGTTSTPKTVPLLHLNIVRSTLNIANTYKLTPLDR--SYVVMPLFHVHGLIGV 248

  Fly   251 LITTACVGARLVYLPKFEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGA 315
            |::|......:|....|..|||.....||.......||.:.:.:...|..:.:. ....:..|.:
Yeast   249 LLSTFRTQGSVVVPDGFHPKLFWDQFVKYNCNWFSCVPTISMIMLNMPKPNPFP-HIRFIRSCSS 312

  Fly   316 APLSRETEDQIKERIGVPFIRQGYGLSESTLSVLVQN--DEFCKPGSVGVLKVGIYAKVIDPDTG 378
            | |:..|..::::....| :.:.|.::|::..:...|  ....|||:||..: |:...::| |..
Yeast   313 A-LAPATFHKLEKEFNAP-VLEAYAMTEASHQMTSNNLPPGKRKPGTVGQPQ-GVTVVILD-DND 373

  Fly   379 KLLGANERGELCFKGDGIMKGYIGDTKSTQTAI--KDGWLHTGDIGYYDDDFEFFIVDRIKELIK 441
            .:|...:.||:..:|:.:..||..:.|:.:...  ::.:..|||.||:|.:....:..||||||.
Yeast   374 NVLPPGKVGEVSIRGENVTLGYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLTGRIKELIN 438

  Fly   442 YKGYQVPPAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNAS- 505
            ..|.::.|.|::.::|::.||.:|...|.||:..|::..|.:|.:...::|..|::.|:..:.:
Yeast   439 RGGEKISPIELDGIMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVNFLKKHLAS 503

  Fly   506 ---PAKRLRGGVIFVDEIPKNPSGKILRRILREMLKK---QKSKL 544
               |.|     |.|||::||..:|||.||::.|...|   .||||
Yeast   504 FKIPTK-----VYFVDKLPKTATGKIQRRVIAETFAKSSRNKSKL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	132/488 (27%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	128/480 (27%)
PCS60	NP_009781.3	FACL_fum10p_like	18..531	CDD:341249	131/486 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I1304
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I924
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46937
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.760