DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and 4CL2

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_188761.1	Gene:	4CL2 / 821678	AraportID:	AT3G21240	Length:	556	Species:	Arabidopsis thaliana

Alignment Length:	524	Identity:	200/524 - (38%)
Similarity:	301/524 - (57%)	Gaps:	24/524 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVKQNDVVGLSSENSVNFA 91
            |..||.:....|..:..|::...|..|:.:.:|.:..:||..|..|||||:|||.:...||....
plant    38 LHDYIFENISEFAAKPCLINGPTGEVYTYADVHVTSRKLAAGLHNLGVKQHDVVMILLPNSPEVV 102

  Fly    92 LAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVKGIIALSG 156
            |...|...:||.....|..::..|:......|..|:|......:|::     ||....|::.::.
plant   103 LTFLAASFIGAITTSANPFFTPAEISKQAKASAAKLIVTQSRYVDKI-----KNLQNDGVLIVTT 162

  Fly   157 TSKKF-KNIYDLKELMEDEKFKTQ--PDFTSPAANKDEDVSLIVCSSGTTGLPKGVQLTQMNLLA 218
            .|... :|.....||.:.|:.:..  |:..||     |||..:..|||||||||||.||...|:.
plant   163 DSDAIPENCLRFSELTQSEEPRVDSIPEKISP-----EDVVALPFSSGTTGLPKGVMLTHKGLVT 222

  Fly   219 TLDSQI---QPTVIPMEEVTLLTVIPWFHAFGCLTLITTAC-VGARLVYLPKFEEKLFLSAIEKY 279
            ::..|:   .|.:....:..:|.|:|.||.:...:::..:. |||.::.:||||..|.|..|::.
plant   223 SVAQQVDGENPNLYFNRDDVILCVLPMFHIYALNSIMLCSLRVGATILIMPKFEITLLLEQIQRC 287

  Fly   280 RVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGVPFIRQGYGLSES 344
            :|.:|.:|||:::.:||.|..:||||||:.::..|||||.:|.||.|..:.....:.||||::|:
plant   288 KVTVAMVVPPIVLAIAKSPETEKYDLSSVRMVKSGAAPLGKELEDAISAKFPNAKLGQGYGMTEA 352

  Fly   345 ----TLSVLVQNDEF-CKPGSVGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKGYIGDT 404
                .:|:....:.| .|.|:.|.:......|::|||||..|..|:.||:|.:|:.|||||:.|.
plant   353 GPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKILDPDTGDSLPRNKPGEICIRGNQIMKGYLNDP 417

  Fly   405 KSTQTAI-KDGWLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIKDAAVI 468
            .:|.:.| |||||||||:|:.|||.|.|||||:||||||||:||.|||:|:||:.:.:|.|.||:
plant   418 LATASTIDKDGWLHTGDVGFIDDDDELFIVDRLKELIKYKGFQVAPAELESLLIGHPEINDVAVV 482

  Fly   469 GKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDNASPAKRLRGGVIFVDEIPKNPSGKILRRIL 533
            ...:|:|||:|:||||:..:..::|:|:.|||:......||: ..|.|.|.|||.|||||||:.|
plant   483 AMKEEDAGEVPVAFVVRSKDSNISEDEIKQFVSKQVVFYKRI-NKVFFTDSIPKAPSGKILRKDL 546

  Fly   534 REML 537
            |..|
plant   547 RARL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	199/522 (38%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	190/498 (38%)
4CL2	NP_188761.1	PLN02246	14..553	CDD:215137	200/524 (38%)
4CL2	NP_188761.1	4CL	32..546	CDD:213272	197/518 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	244	1.000	Domainoid score	I559
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I670
OMA	1	1.010	-	-		QHG54045
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	1	1.000	-	-		FOG0000951
OrthoInspector	1	1.000	-	-		otm2541
orthoMCL	1	0.900	-	-		OOG6_100107
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880